Depressive Symptoms and Neurocognitive Performance Among HIV-Infected Women

Fialho, Renata; Pereira, Marco; Mendonça, Nuno; Ouakinin, Sílvia

doi:10.1080/03630242.2013.767301

Cited by 16 publications

(17 citation statements)

References 69 publications

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“…The model was strengthened when HDS was combined with BDI. This finding is also not unexpected, as there is reason to believe that depression is related to HAND both via molecular and behavioral avenues (Atkinson et al 2008; Leserman 2008; Dantzer and Kelley 2007; Raison et al 2006; Fialho et al 2013); however, the relationship is far from unequivocal.…”

Section: Discussionmentioning

confidence: 79%

Factors related to HIV-associated neurocognitive impairment differ with age

Fogel

Lamers²,

Levine

et al. 2014

J. Neurovirol.

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Over 50% of HIV-infected (HIV+) persons are expected to be over age 50 by 2015. The pathogenic effects of HIV, particularly in cases of long-term infection, may intersect with those of age-related illnesses and prolonged exposure to combined antiretroviral therapy (cART). One potential outcome is an increased prevalence of neurocognitive impairment in older HIV+ individuals, as well as an altered presentation of HIV-associated neurocognitive disorders (HAND). METHODS In this study, we employed stepwise regression to examine 24 features sometimes associated with HAND in forty older (55–73 years of age) and thirty younger (32–50 years of age) HIV+, cART-treated participants without significant central nervous system confounds. RESULTS The features most effective in generating a true assessment of the likelihood of HAND diagnosis differed between older and younger cohorts, with the younger cohort containing features associated with drug abuse that were correlated to HAND, and the older cohort containing features that were associated with lipid disorders mildly associated with HAND. CONCLUSION As the HIV-infected population grows and the demographics of the epidemic change, it is increasingly important to re-evaluate features associated with neurocognitive impairment. Here we have identified features, routinely collected in primary care settings that provide more accurate diagnostic value than a neurocognitive screening measure among younger and older HIV-individuals.

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Section: Discussionmentioning

confidence: 79%

Factors related to HIV-associated neurocognitive impairment differ with age

Fogel

Lamers²,

Levine

et al. 2014

J. Neurovirol.

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“…Comorbid conditions in HIV-infected adults such as depressive symptoms, substance use, and hepatitis C infection significantly affect neurocognitive function(Fialho et al, 2013; Grant, 2008; Martin-Thormeyer and Paul, 2009). HIV-related factors, including HIV-RNA level and CD4 nadir, also negatively impact on neurocognition (Childs et al, 1999; Ferrando et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons

Okafor

Kelso

Bryant

et al. 2016

Psychology, Health & Medicine

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To determine the relationships among body mass index (BMI), and HIV-associated neurocognitive impairment and the potential mediating effects of inflammatory cytokines. Among the HIV-infected individuals (N=90) included in this study, obesity was associated with slower processing speed (β = −.229, standard error (SE) = 2.15, p = .033), compared to participants with a normal BMI, after controlling for psychosocial and HIV clinical factors. Serum concentrations of the interleukin-16 (IL-16) cytokine were significantly associated with slowed processing speed (β = −.235, standard error (SE) = 1.62, p = .033) but did not mediate the relationship between obesity and processing speed These findings suggest that obesity may contribute to cognitive processing speed deficits in HIV-infected adults. Elevated concentrations of IL-16 are also associated with slowing, though the results suggest that obesity and IL-16 may exert independent effects.

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“…Depresyonun HIV (+) hastalarda, tedavi uyumunu azalttığı, var olan bilişsel bozulmayı arttırdığı, özellikle motor işlevler, dikkat, bilgi işleme hızı, yürütücü işlevler ve bellek alanları üzerine olumsuz etki ettiği ve yaşam kalitesini bozduğu bilinmekte, bu durum depresyonun tanınması ve tedavi edilmesinin önemini göstemektedir 26 .…”

Section: Tablo 1 Hiv (+) Hastaların Sosyo-demografik öZellikleriunclassified

HIV pozitif hastaların nöropsikiyatrik açıdan değerlendirilmesi: bir ön çalışma

Keskin¹,

Evlice²,

Çakmak³

et al. 2017

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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AbstractÖz Purpose: The aim of this study was to assess neuropsychiatric symptoms of HIV infected patients and determine related socio-demographic and clinical features. Material and Methods: A total of 10 HIV (+) outpatients who have been followed in Department of Infectious Diseases and Clinical Microbiology, Cukurova University Medical School were included in the study. To evaluate cognitive functions, a neuropsychological test battery consisted of 8 tests were administered. All patients completed Symptom Check List (SCL-90) to determine psychological symptoms and Hamilton Depression Rating Scale (HAM-D) were used to evaluate the severity of depression.

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Depressive Symptoms and Neurocognitive Performance Among HIV-Infected Women

Cited by 16 publications

References 69 publications

Factors related to HIV-associated neurocognitive impairment differ with age

Factors related to HIV-associated neurocognitive impairment differ with age

Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons

HIV pozitif hastaların nöropsikiyatrik açıdan değerlendirilmesi: bir ön çalışma

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