History, Applications, Activity and Changes of Citrinin

Abstract

Abstract:Citrinin is a natural product obtained from fungi and with good biological activity. Because this compound also presents toxicity, especially being nephrotoxicity, its structural modification is important to obtain new potential pharmacological agents without toxicity. This article presents the history, obtention methods, synthesis, structural modification, evaluation and biological activity of citrinin.Keywords: Citrinin; Penicillium; mycotoxins; biosynthesis; antibiotic; nephrotoxicity. ResumoA Citrinina é um produto natural obtido de fungos e com boa atividade biológica. Como ela também apresenta certa toxidez, especialmente sendo nefrotóxica, é importante sua modificação estrutural para obter novos fármacos sem essa toxidez. Este artigo apresenta a história, os métodos de obtenção, síntese, modificação estrutural, avaliação e atividade biológica da citrinina.

Antimicrobial Potential of Extracts from <em>Penicillium purpurogenum</em> Isolated from Aquatic Environment in the Amazon and Identification of Citrinin Derivatives

“…Moreover, they exhibit various biological activities, including antibacterial effects [24,38], which is highly relevant in the current context where certain microorganisms like Staphylococcus aureus and Enterococcus spp. have developed resistance to specific antibiotics [40]. Hence, there is a pressing need for the exploration of new antimicrobial compounds, and citrinin derivatives such as dihydrocitrinin and 1-methyl-dihydrocitrinine emerge as promising candidates for this purpose.…”