“…During World War I it was used by Alexis Carrel and Henry D. Dakin as an effective antiseptic agent for combat wounds, sparking its popularity as a wound antiseptic between the two world wars. The popularity of such use later declined with the rise of antibiotics, but it remained a popular household productsodium hypochlorite is the active ingredient in bleach [39].…”
Section: Sodium Hypochloritementioning
confidence: 99%
“…Today a 0.5% sodium hypochlorite solution or more diluted preparations are used. Dakin's solution has been known to have a bactericidal effect against S. aureus (MRSA and non methicillin-resistant), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter cloacae, group D enterococci, Bacteroides fragilis, Streptococcus mitis, Staphylococcus epidermidis, and a fungicidal effect on Candida albicans among others [39].…”
The process of wound healing is often accompanied by bacterial infection or critical colonization, which leads to an extension of the inflammatory response phase and delayed epithelization. In the review of scientific articles, we found the description and mode of action of topical antiseptic agents, including silver and sodium hypochlorite solution, to control the spread of microorganisms. The value of hyaluronic acid for wound healing is described. Furthermore, a novel treatment option with microspheres is mentioned. Attachment of cells to microspheres establishes a local cytokine response that acts anti-inflammatory, cell attachment results also in morphological and functional cell changes that reactivate healing.
“…During World War I it was used by Alexis Carrel and Henry D. Dakin as an effective antiseptic agent for combat wounds, sparking its popularity as a wound antiseptic between the two world wars. The popularity of such use later declined with the rise of antibiotics, but it remained a popular household productsodium hypochlorite is the active ingredient in bleach [39].…”
Section: Sodium Hypochloritementioning
confidence: 99%
“…Today a 0.5% sodium hypochlorite solution or more diluted preparations are used. Dakin's solution has been known to have a bactericidal effect against S. aureus (MRSA and non methicillin-resistant), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter cloacae, group D enterococci, Bacteroides fragilis, Streptococcus mitis, Staphylococcus epidermidis, and a fungicidal effect on Candida albicans among others [39].…”
The process of wound healing is often accompanied by bacterial infection or critical colonization, which leads to an extension of the inflammatory response phase and delayed epithelization. In the review of scientific articles, we found the description and mode of action of topical antiseptic agents, including silver and sodium hypochlorite solution, to control the spread of microorganisms. The value of hyaluronic acid for wound healing is described. Furthermore, a novel treatment option with microspheres is mentioned. Attachment of cells to microspheres establishes a local cytokine response that acts anti-inflammatory, cell attachment results also in morphological and functional cell changes that reactivate healing.
“…Solução, solução spray e gel HOCl (0,04%) + NaOCl (0,06%) 3 HOCl -0,033% 55 NaOCl (Soluto de Dakin) -0,125%, 0,025%, 0,05% 56 , < 0,06% 3 Disponível no Brasil IWII-Swanson, 2016 2 Kramer, 2018 3 Day, 2017 55 Ueno, 2018 56…”
Section: Hipoclorito De Sódio (Naocl) / áCido Hipocloroso (Hocl)unclassified
“…Exerce atividade bactericida por ser agente oxidante 3,56 em concentração a 0,05%. Erradicou 100% biofi lme de S. aureus e P. aeruginosa, em 30 minutos de contato 58 .…”
Section: Revisãounclassified
“…Análise da "1ª Recomendação Brasileira para o Gerenciamento de Biofi lme em Feridas Crônicas e Complexas" estudos que sustentem o uso de cranberry e N-acetilcisteína (NAC) para prevenção ou controle de bio lme em feridas.O peróxido de hidrogênio ou água oxigenada (H 2 O 2 ) é considerado obsoleto para uso em feridas pois, em concentrações a partir de 8,5 mg/L, já inibe a proliferação de broblastos, enquanto as bactérias permanecem viáveis3,56 . É importante salientar que o H 2 O 2 é formado em concentrações não citotóxicas em mel medicinal pela reação de glicose oxidase, mas esse efeito não é comparável ao H 2 O 2 externo, quando aplicado puro e sozinho3 .…”
Objetivos: Analisar criticamente a “1ª Recomendação brasileira para o gerenciamento de biofilme em feridas crônicas e complexas”. Método: Realizou-se revisão da literatura atual às informações nele contidas. Resultados: Observou-se que a publicação carece de metodologia compatível com o título, existem lacunas nas recomendações quanto à classificação das evidências e com ausência de fundamentação a partir de importantes consensos internacionais para o tratamento das feridas complexas com suspeita de biofilme, publicados nos últimos três anos. Conclusão: Conclui-se que o manuscrito não deve ser usado como guia de recomendações clínicas, mas como revisão bibliográfica sobre o tema.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.