Historical Review

Payne, L. N.

doi:10.1007/978-1-4613-2613-7_1

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…These vaccines provided the first accounts of the efficient prevention of cancer caused by a DNA tumorvirus. A number of excellent and recent reviews on this topic cover the historical, oncogenic, genetic, and immunologic aspects of MDV infection as a model for oncogenic herpesviruses (8,12,34,50,54).…”

Section: Six Cell Lines Derived Frommentioning

confidence: 99%

Status of Marek's disease virus in established lymphoma cell lines: herpesvirus integration is common

Delecluse

Hammerschmidt

1993

J Virol

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Six cell lines derived from Marek's disease lymphomas of chickens and turkeys were investigated for the status of Marek's disease virus (MDV) DNA. In the transformed T- and B-cell lines, viral DNA could be detected by conventional Southern blot hybridization, by Gardella gel electrophoresis, and by in situ hybridization of metaphase and interphase chromosomes. Integration of viral DNA into the host cell chromosome was observed in all cell lines. Two to 12 integration sites of viral DNA could be detected in metaphase chromosome spreads. The integration sites were characteristic for the individual cell lines and were preferentially located at the telomers of large- and mid-sized chromosomes or on minichromosomes. In four of six cell lines, a minor population of latently infected cells supported the lytic cycle of MDV, giving rise to linear virion DNAs. In one of these cell lines, a third species of MDV DNA could be detected with properties reminiscent of covalently closed circular DNA. The finding that MDV integrates regularly into the genomes of latently infected cells is crucial to understanding the molecular biology of herpesvirus-induced tumors in the natural host.

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Section: Six Cell Lines Derived Frommentioning

confidence: 99%

Status of Marek's disease virus in established lymphoma cell lines: herpesvirus integration is common

Delecluse

Hammerschmidt

1993

J Virol

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“…As early as 1929, visceral lymphomatous tumors were described in several birds with "fowl paralysis" [25]. Histopathologic examination of these tumors revealed closely packed round cells with the appearance of lymphoid cells [26,27]. As such this disease was part of a group of diseases often referred to as the avian leukosis complex which included visceral lymphomas caused by filterable leukosis viruses, while tumors associated with fowl paralysis could not be reproduced with filtrates [28].…”

Section: The Pathogenesis Of Marek's Disease: the Early Years Until 1975mentioning

confidence: 99%

The Importance of the Bursa of Fabricius, B Cells and T Cells for the Pathogenesis of Marek’s Disease: A Review

Schat

2022

Viruses

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The importance of the bursa of Fabricius (BF) for the pathogenesis of Marek’s disease (MD) has been studied since the late 1960’s. In this review, the results of these studies are analyzed in the context of the developing knowledge of the immune system of chickens and the pathogenesis of MD from 1968 to 2022. Based on the available techniques to interfere with the development of the BF, three distinct periods are identified and discussed. During the initial period between 1968 and 1977, the use of neonatal bursectomy, chemical methods and irradiation were the main tools to interfere with the B lymphocyte development. The application of these techniques resulted in contradictory results from no effects to an increase or decrease in MD incidence. Starting in the late 1970’s, the use of bursectomy in 18-day-old embryos led to the development of the “Cornell model” for the pathogenesis of MD, in which the infection of B lymphocytes is an important first step in MD virus (MDV) replication causing the activation of thymus-derived lymphocytes (T cells). Following this model, these activated T cells, but not resting T cells, are susceptible to MDV infection and subsequent transformation. Finally, B-cell knockout chickens lacking the J gene segment of the IgY heavy chain gene were used to further define the role of the BF in the pathogenesis of MD.

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“…Unsurprisingly, the most common species present are sheep and goats. In most cases, it proved impossible to differentiate between these species, a common problem that derives from the fact that sheep and goats are differentiable only on the basis of a few skeletal elements (cf., e.g., Boessneck, Müller, and Teichert 1964;Halstead, Collins, and Isaakidou 2002;Payne 1985;Prummel and Frisch 1986;Zeder and Pilaar 2010) without recourse to new genetic separation techniques (cf. Buckley et al 2010).…”

Section: Kma's Faunal Assemblage: Presentation and Analysismentioning

confidence: 99%

Measuring Local Diversity in Early Iron Age Animal Economies: A View from Khirbat al-Mudayna al-ʿAliya (Jordan)

Lev-Tov¹,

Porter²,

Routledge³

2011

Bulletin of the American Schools of Oriental Research

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We use faunal evidence from Khirbat al-Mudayna al-ʿAliya, an agropastoral settlement located in west-central Jordan, to examine early Iron Age subsistence regimes. Analysis of faunal evidence reveals a low-intensity, nonspecialized animal economy dependent on both domesticated and wild species, including freshwater crabs. The subsistence economy of the settlement, we argue, was structured so as to take maximum advantage of its location overlooking the Wadi al-Nukhayla, a perennial water source supporting a relatively verdant floral and faunal array. This diverse and flexible organization made subsistence in this resource-scarce environment more sustainable. When this profile is compared with other early Iron Age southern Levantine communities, the diversity of ways that animal economies were organized during this period is apparent, signaling the need to investigate the local strategies that communities used to adapt to their immediate environmental circumstances, not only ecologically but also socially.

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Historical Review

Cited by 6 publications

References 22 publications

Status of Marek's disease virus in established lymphoma cell lines: herpesvirus integration is common

Status of Marek's disease virus in established lymphoma cell lines: herpesvirus integration is common

The Importance of the Bursa of Fabricius, B Cells and T Cells for the Pathogenesis of Marek’s Disease: A Review

Measuring Local Diversity in Early Iron Age Animal Economies: A View from Khirbat al-Mudayna al-ʿAliya (Jordan)

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