Historical perspective on ADP-induced platelet activation

Packham, Marian A.; Rand, Margaret L.

doi:10.1007/s11302-011-9227-x

Cited by 24 publications

(15 citation statements)

References 123 publications

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“…The signalling circuitry that controls platelet activation processes is impressively complex and not completely understood. A separate review would be required to cover this topic, and indeed, several are available [16,17,22,60,77,80,90,136,137]. Information is also available in textbooks [84].…”

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

“…[58] for an interesting review). For several of the agonists, there is more than one receptor: P2Y1 and P2Y12 for ADP; [62,90] protease activated receptors PAR1 and PAR4, [17] as well as GPIb, [109] for thrombin [22]. Some of these are shown in Fig.…”

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

“…Its binding to the P2Y12 receptor drives GPIIb/IIIa conformational change. Platelet aggregation, which is initially reversible, [90] leads to the activation of PLA2 and thromboxane synthesis. TXA2 is released by the platelets (purple dashed arrow in Fig.…”

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

“…3). Aggregation becomes irreversible [90]. Aspirin, which blocks TXA2 production, inhibits dense granule secretion and the second (irreversible) phase of aggregation, but not the calcium rise, the shape change, or the first (reversible) wave of aggregation caused by ADP (Fig.…”

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

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New horizons in platelet research: Understanding and harnessing platelet functional diversity

Reviakine

2015

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Recent years have been ripe with discoveries of non-haemostatic platelet functions. This led to the appreciation of the significant, previously unknown, role played by the platelets in various pathologies and regenerative processes. As a result, exciting opportunities for clinical applications in fields as diverse as regenerative medicine and cancer treatment are emerging. However, their realization depends on the understanding of the regulatory mechanisms governing these diverse platelet functions, so that particular platelet responses could be artificially tailored to specific clinical situations. Current understanding of the signalling pathways controlling haemostatic responses is rooted in the development of quantitative assays for measuring them and sensitive markers for their quantification. However, the existing assays and markers are not sufficiently sensitive for distinguishing between individual signalling pathways and unravelling inter-pathway connections. Moreover, entirely new approaches are needed for studying non-haemostatic platelet functions, since there are currently no assays or markers for quantifying them. We review the on-going efforts in these directions, including our own recent work on using lectins as sensitive probes for profiling platelet activation.

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Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

Section: Platelet Signalling Pathwaysmentioning

confidence: 99%

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New horizons in platelet research: Understanding and harnessing platelet functional diversity

Reviakine

2015

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“…The second amplification loop is related to the role of adenosine 5′‐diphosphate (ADP) either released from the red blood cells and/or from the platelet dense granules . It is known for long now that ADP is a platelet activating factor derived from red blood cells and from platelets themselves which plays crucial roles in the physiological process of haemostasis and in the development and extension of arterial thrombosis . However, it took 8 years from the cloning of the first P2Y receptor to the completion of the repertoire of the platelet ADP receptors as well as other platelet P2 receptors.…”

Section: Introductionmentioning

confidence: 99%

The P2Y receptors and thrombosis

Gachet

Hechler

2013

WIREs Membr Transp Signal

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Blood platelets play a key role in arterial thrombosis which is one of the leading causes of mortality in western countries. They may also be involved in the pathogenesis of deep vein thrombosis. Adenosine 5 -diphosphate (ADP) is one of the most important mediators of platelet activation. Two G protein-coupled ADP receptors, P2Y1 and P2Y12, selectively contribute to platelet aggregation and formation of a thrombus. Playing a central role in platelet activation and in growth and stabilization of a thrombus, the P2Y12 receptor is an established target of antithrombotic drugs like the thienopyridines clopidogrel or prasugrel, or direct reversible antagonists such as ticagrelor or cangrelor. Each of these drugs has proven efficacy in large clinical trials. At a preclinical stage, studies in P2Y1 deficient mice and using selective P2Y1 antagonists in experimental models of thrombosis and inflammation have shown that this receptor is also an attractive target for new antithrombotic compounds.

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Antiplatelet Agents: Current and Novel

Heptinstall

2012

Antiplatelet and Anticoagulation Therapy

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Historical perspective on ADP-induced platelet activation

Cited by 24 publications

References 123 publications

New horizons in platelet research: Understanding and harnessing platelet functional diversity

New horizons in platelet research: Understanding and harnessing platelet functional diversity

The P2Y receptors and thrombosis

Antiplatelet Agents: Current and Novel

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