Historical Control Data of Organ Weight and Gross Findings in F344/DuCrj Rats and B6C3F&lt;SUB&gt;1&lt;/SUB&gt; Mice

Iwata, Hijiri; Hagiwara, Takeshi; Katoh, Mutsumi; Yamamoto, Sanae; Yamakawa, Seiki; Shiga, Atsushi; Hirouchi, Yasuhiko; Kobayashi, Kazuo; Inoue, Hiroyuki; Enomoto, Makoto

doi:10.1538/expanim1978.42.3_383

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…Although no abnormality was apparent at the time of dissection, it cannot be ruled out that in the 3 mice with large spleens in this age-group a pathological state could be responsible for the results. Interestingly, a similar spleen enlargement was noted previously around this age in B6C3F1 and CBA/Ca mice (Iwata et al, 1993;Marino, 2012;Penzes et al, 1989). No correlation between spleen organ weight and body weight was detected in our study.…”

Section: Discussionsupporting

confidence: 87%

Characterization of age-associated changes in peripheral organ and brain region weights in C57BL/6 mice

Lessard‐Beaudoin

Laroche

Demers

et al. 2015

Experimental Gerontology

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Section: Discussionsupporting

confidence: 87%

Characterization of age-associated changes in peripheral organ and brain region weights in C57BL/6 mice

Lessard‐Beaudoin

Laroche

Demers

et al. 2015

Experimental Gerontology

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“…In rats and other species, the absolute weights of many, but not all, organs are affected by growth during the normal life span during which toxicity studies are conducted (Simpson and Spears, 1973;Schärer, 1977;Iwata et al, 1993;Kihara et al, 1993;Teramoto et al, 1996). Comparison of organ weights in these studies shows small differences in the absolute weights of some organs (e.g., adrenal glands), but large and often proportional differences in absolute weights of other organs (e.g., liver).…”

Section: Results In Tablementioning

confidence: 99%

“…Using relative organ weights to interpret the effect of the compound can introduce error and mislead the investigator regarding the effect of the compound on the or-gan. Similarly, relative weights of most organs change as normal animals grow (Dikstein et al, 1967;Simpson and Spears, 1973;Iwata et al, 1993;Teramoto et al, 1996). These data imply that growth retardation induced by treatment with experimental compounds will result in artifactual changes in the relative weights of some organs, unless there are specific toxic effects on those organs.…”

Section: Results In Tablementioning

confidence: 99%

Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

Bailey¹,

Zidell

Perry³

2004

Toxicol Pathol

357

218

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Analysis of organ weight in toxicology studies is an important endpoint for identification of potentially harmful effects of chemicals. Differences in organ weight between treatment groups are often accompanied by differences in body weight between these groups, making interpretation of organ weight differences more difficult. Using data from control rats that were part of 26 toxicity studies conducted under similar conditions, we have evaluated the relationship between organ weight and body/brain weight to determine which endpoint (organ weight, organ-to-body weight ratio, or organ-to-brain weight ratio) is likely to accurately detect target organ toxicity. This evaluation has shown that analysis of organ-to-body weight ratios is predictive for evaluating liver and thyroid gland weights, and organ-to-brain weight ratios is predictive for evaluating ovary and adrenal gland weights. Brain, heart, kidney, pituitary gland, and testes weights are not modeled well by any of the choices, and alternative analysis methods such as analysis of covariance should be utilized.

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“…On the other hand, lower thymus weights observed in males may be related to the natural atrophy of this organ that is first noted in males before females (Iwata et al 1993).…”

Section: Discussionmentioning

confidence: 97%

Reference data for the principal physiological indicators in three species of laboratory animals

et al. 2000

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SummaryThis paper contains the reference data for the main physiological indicators of three species of laboratory animals: mice, rabbits and dogs. Data listed include the mean and the standard deviation of haematology, serum biochemistry and organ weight to body weight ratio. In addition, pathological studies including microscopical examination of organs and tissues were also done. Comparisons between sexes were analysed.

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Historical Control Data of Organ Weight and Gross Findings in F344/DuCrj Rats and B6C3F<SUB>1</SUB> Mice

Cited by 16 publications

References 13 publications

Characterization of age-associated changes in peripheral organ and brain region weights in C57BL/6 mice

Characterization of age-associated changes in peripheral organ and brain region weights in C57BL/6 mice

Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

Reference data for the principal physiological indicators in three species of laboratory animals

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