Historical Cohort Study of the Efficacy and Safety of Piperacillin/Tazobactam Versus Fourth-Generation Cephalosporins for Empirical Treatment of Febrile Neutropenia in Patients with Hematological Malignancies

Saito, Takashi; Ichinohe, Tatsuo; Kanda, Junya; Nagao, Miki; Takakura, Shunji; Ito, Yutaka; Iinuma, Yoshitsugu; Yamashita, Kouhei; Kondo, Tadakazu; Ishikawa, Takayuki; Uchiyama, Takashi; Ichiyama, Satoshi

doi:10.4236/ijcm.2011.21005

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Previous studies mostly focused on the efficacy of fourth-generation cephalosporins; however, few clinical studies reported their associated renal function adverse effects (3)(4)(5). Cefpirome caused nephrotoxic symptoms in a rabbit model and the results suggested that cefpirome is potentially nephrotoxic compared to cefazolin, particularly in a single administration (6,7).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the influence on renal function between cefepime and cefpirome

et al. 2015

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Abstract. Although known for their broad spectrum and curative efficacy on drug-resistant pathogens and as nephrotoxicity-free, impairments were observed on renal function during clinical treatment of the two most commonly used fourth-generation cephalosporins: Cefpirome and cefepime. The present study aimed to further explore the exact influences of them on renal function. In vitro, the cell viability of renal cells cultured in drug-combined medium was tested for six dilutions. In vivo, a clinical cohort study was carried out to detect the influence of cefpirome and cefepime on the serum creatinine (SCr) level of patients. Cefpirome had an inhibition rate with half maximal inhibitory concentration (IC 50 ) of 143.5 µmol/l on renal mesangial cells, which was greater compared to the IC 50 of 7.702 µmol/l for cefepime. The clinical cohort study data revealed that cefpirome treatment could lead to a greater increase of the average SCr level compared to cefepime on days 3 and 7 during therapy, and in addition, a greater incidence of SCr >445 µmol/l, an indicator of clinical renal failure. Furthermore, patients with an average age >65 years were observed as more susceptible to an SCr rise caused by either cefpirome or cefepime, with a larger augment in the average SCr, as well as a higher incidence of SCr >445 µmol/l compared to patients aged <65 years. In conclusion, cefpirome may have more potential to cause renal impairment compared to cefepime, therefore, more caution and comprehensive analysis of patient conditions is required during the clinical choice of fourth-generation cephalosporins.

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Section: Introductionmentioning

confidence: 99%

Comparison of the influence on renal function between cefepime and cefpirome

et al. 2015

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Anti-neoplastic effect of epigallocatechin gallate on breast cancer cells through glucose metabolism

AL-Shaeli

Ethaeb

Brown

2019

J. Phys.: Conf. Ser.

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Breast cancer (BC) is the primary cause of women cancer death, which could be prevented by EGCG that has been recently shown several health properties included anti-cancer, however the mechanism underpinning still poorly understood. In this study, several biological activities of both MCF7 and MDA-MB-231 cells were evaluated in response to EGCG. Cell viability and the role of Akt and AMPK inhibitor molecules, and sodium pyruvate on this viability, apoptosis, metastasis, and interestingly regulation of glucose metabolism were assessed. EGCG promoted cytotoxicity in both BC cell lines after 24h but not less. Co-incubated cells with Akt and AMPK inhibitors alongside EGCG significantly caused more reduction in cell viability compared to the effect of EGCG alone with maximum effect referred to Akt inhibitor. While supplemented sodium pyruvate significantly restored the decreases in cell viability. Remarkably, EGCG induced apoptosis through increased caspase 3/7 activation associated with upregulated Bax gene, in addition to anti-metastatic effect through decreasing cellular migration. Importantly, lactate production was sharply reduced after 6h (no alteration of viable cells) and 24h (decreased viable cells) concomitant with significant blocked glucose uptake in response to EGCG. In conclusion, EGCG could be a potential anti-migration, the anti-cancerous therapeutic agent through targeting cancer cells glucose metabolism.

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Historical Cohort Study of the Efficacy and Safety of Piperacillin/Tazobactam Versus Fourth-Generation Cephalosporins for Empirical Treatment of Febrile Neutropenia in Patients with Hematological Malignancies

Abstract: We retrospectively evaluated the efficacy and safety of the combination drug piperacillin/tazobactam

Cited by 2 publications

References 16 publications

Comparison of the influence on renal function between cefepime and cefpirome

Comparison of the influence on renal function between cefepime and cefpirome

Anti-neoplastic effect of epigallocatechin gallate on breast cancer cells through glucose metabolism

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