Historical Aspects of the Oral Use of Retinoids in Acne

Hartmann, D; Bollag, W.

doi:10.1111/j.1346-8138.1993.tb01362.x

Cited by 11 publications

(4 citation statements)

References 20 publications

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“…In 1971, clinical trials' results revealed that isotretinoin was ineffective for treating skin cancer, but could be useful for the management of AV. However, due to concerns about its side effects and its potential to cause birth defects in particular, the medication was not released to the market until 1982 [ 19 ]. Isotretinoin is, by far, the most cost-effective drug when compared with other medications used for severe acne treatment.…”

Section: Discussionmentioning

confidence: 99%

Patients’ Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan

Jarab

Al‐Azzam

Al-Mutairi

et al. 2022

International Journal of Clinical Practice

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Background. Despite being the first-line treatment for severe or moderate acne, isotretinoin has several serious side effects that necessitate the evaluation of patients’ knowledge about isotretinoin side effects and its proper use. Objective. The current study aim was to explore information needs about isotretinoin by evaluating patients’ knowledge about the appropriate use of isotretinoin and its associated side effects. Methods. In addition to the sociodemographic variables, a validated online questionnaire was adopted from the literature to evaluate patients’ knowledge about isotretinoin use and its potential side effects. Independent t-test and one-way analysis of variance (ANOVA) test were implemented to find the correlation between the study variables and the knowledge score. Results. The most recognized side effect of isotretinoin therapy was dryness (98.1%). The study patients showed good knowledge about isotretinoin use with a mean knowledge score of 8.1 (SD = 0.7). However, more than half of them (61.0%) mistakenly thought that isotretinoin therapy should be taken continuously for more than 6 months without stop, and some of them did not know that isotretinoin is recommended to be taken with fatty meal (24%) and sunblock (24.6%). Female gender (8.2 (SD = 0.8)) and using isotretinoin for more than 6 months (8.3 (SD = 1.2)) were significantly associated with a higher knowledge score of isotretinoin use ( p = 0.01 ), when compared with male patients (7.8 (SD = 0.7)) and less than 6-month use of isotretinoin (7.7 (SD = 0.7)). Conclusions. The lack of patients’ information about the potential side effects, duration of therapy, and some instructions on isotretinoin use, such as taking the medication with fatty meal and sunblock, shed the light on the necessity to prepare leaflets, educational brochures, and educational posts via social media in order to improve patients’ knowledge about isotretinoin therapy and its optimal use.

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Section: Discussionmentioning

confidence: 99%

Patients’ Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan

Jarab

Al‐Azzam

Al-Mutairi

et al. 2022

International Journal of Clinical Practice

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“…53 The correlation of oral vitamin A and its therapeutic effects for AV was first shown in a clinical study in 1942. 54 This eventually became the basis for the development of tretinoin in the 1960s and isotretinoin in the 1970s. 5,54 It has also been observed that low levels of vitamin C are associated with poor wound healing and compensatory thickening of the stratum corneum.…”

Section: Diet and Metabolismmentioning

confidence: 99%

“…54 This eventually became the basis for the development of tretinoin in the 1960s and isotretinoin in the 1970s. 5,54 It has also been observed that low levels of vitamin C are associated with poor wound healing and compensatory thickening of the stratum corneum. 53 Taken together, these data suggest that appropriate levels of these and other vitamins and minerals could contribute to improving AV by supporting several of the important physiological mechanisms needed for healthy skin, with some observations more closely related to AV pathophysiology.…”

Section: Diet and Metabolismmentioning

confidence: 99%

New Insights Into Systemic Drivers of Inflammation and Their Contributions to the Pathophysiology of Acne

Del Rosso,

Farris,

Harper

et al. 2024

JDD

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Acne Vulgaris (AV) is a prominent skin disease commonly affecting teenagers. It often persists into adulthood and is associated with adverse physical and psychosocial impacts. The pathophysiology of AV is conventionally correlated with 4 factors within and around the pilosebaceous unit: increased sebum production, follicular hyperkeratinization, Cutibacterium acnes proliferation, and localized immune responses. As such, conventional therapeutic approaches for AV have primarily focused on these factors. In addition to this primarily localized pathophysiology, there is a progressively emerging body of evidence indicating that underlying systemic factors contributing to a generalized immuno-inflammatory response can contribute to or exacerbate AV. In this article, we introduce and provide the supporting data, for 6 patient-centric systems that may be implicated in the development of AV: psycho-emotional stress, diet and metabolism, dysbiosis of the gut and skin microbiome, hormonal fluctuations, oxidative stress, and immune response. Identifying these pathways and their contributions in a patient-centric approach may provide expanded therapeutic opportunities for treating patients with AV.

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“…The results of these trials were very encouraging. Daily doses between 5 and 20 mg given for 12 weeks resulted in good to excellent responses in about 80% of all cases including the severe cystic forms of acne' [327]. …”

Section: From Vitamin a To Isotretinoin: Innovative Views On Acne Patmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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Historical Aspects of the Oral Use of Retinoids in Acne

Cited by 11 publications

References 20 publications

Patients’ Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan

Patients’ Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan

New Insights Into Systemic Drivers of Inflammation and Their Contributions to the Pathophysiology of Acne

Acne Pathogenesis: History of Concepts

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