Patients’ Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan

Jarab, Anan S.; Al‐Azzam, Sayer; Al-Mutairi, Shriefa; Mukattash, Tareq L.

doi:10.1155/2022/9443884

Cited by 11 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It underscores the importance of monitoring and addressing ocular changes during isotretinoin treatment to ensure the well-being and visual health of the patients. This supports the findings of Jarab et al (2022) [ 16 ], who found a comparable percentage of participants experiencing worsened or new eye symptoms prior to isotretinoin treatment.…”

Section: Discussionsupporting

confidence: 91%

Isotretinoin-Related Eye Dryness in Acne Patients in Qassim, Saudi Arabia

Alfouzan,

Al-Hammad,

Alkhuzayem

et al. 2023

Cureus

View full text Add to dashboard Cite

Background Isotretinoin is a commonly prescribed agent mainly used to treat acne vulgaris. Since its Food and Drug Administration (FDA) approval, the subject of its associations with various medical conditions has become a growing interest in many investigational studies. Methodology A retrospective study was conducted using the validated Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire. All statistical calculations were performed using the Statistical Package for the Social Sciences (SPSS) version 27.0.1 (IBM SPSS Statistics, Armonk, NY). Results The research study involved 107 participants, predominantly Saudi nationals (98.1%), with an average age of 22 years. Regarding the total cumulative dose (TCD), 40.2% had less than 50 mg/kg, 33.6% had between 50 and 100 mg/kg, and 15.9% had more than 100 mg/kg. The majority (73.8%) did not stop using isotretinoin. The average Ocular Surface Disease Index (OSDI) score, indicating ocular surface disease symptoms, was 26.78. There was no significant association between gender, dose/duration of isotretinoin, TCD, and age, and OSDI scores. However, participants with severe OSDI scores were more likely to have worsened pre-existing eye symptoms compared to those with non-severe OSDI scores (35.1% versus 11.4%, p = 0.011). Conclusions This study contributes to the understanding of the impact of isotretinoin usage on ocular surface health. While no significant associations were found between gender, dose, duration, TCD, and age, and OSDI scores, participants with pre-existing eye symptoms were more likely to experience worsened symptoms during isotretinoin treatment.

show abstract

Section: Discussionsupporting

confidence: 91%

Isotretinoin-Related Eye Dryness in Acne Patients in Qassim, Saudi Arabia

Alfouzan,

Al-Hammad,

Alkhuzayem

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…The duration of treatment with isotretinoin, as recommended by the AAD, is minimally 3 months, up to the maximum duration of 6 months. In this study, 25% of participants had used isotretinoin for an improper duration of treatment, which is lower than the findings of other studies; for example, the improper duration reported was 35% in a study conducted in Quebec City study, 10 68% of a Saudi female college students’ students’ study, 14 and 44.7% in the Jordan University of Science and Technology study, 15 all had undergone a duration of therapy longer than 6 months. 1 , 12 , 13 Adherence to the treatment duration is essential for the efficacy and prevention of long-term damage and complications with longer treatment durations, such as permanent loss of eyesight, erectile dysfunction, and loss of libido.…”

Section: Discussioncontrasting

confidence: 67%

“… 2 For example, in a Jordanian study, 98.4% of patients were informed about the contraindication of blood donation, and 75.4% were informed about the importance of hydration and sunblock, respectively. 15 Also, in a study performed in the western region of Saudi Arabia, 84.6% of patients were informed about isotretinoin side effects by physicians and pharmacists. 18 The low adherence in clinical practice regarding patient counseling and educations is due to the lack of pharmacy practice laws that enforce patient counseling as not only ethical responsibility for practitioners but also a legal one that is required by laws.…”

Section: Discussionmentioning

confidence: 99%

Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

Abukhalil,

Yousef,

Ammar

et al. 2024

PPA

View full text Add to dashboard Cite

Background Isotretinoin is a commonly prescribed medication for the treatment of acne. It is associated with serious side effects that require monitoring and adherence by patients and healthcare providers. No studies have been conducted in Palestine to explore isotretinoin prescribing and utilization. Objective This study aims to evaluate the current clinical practices, adherence to clinical guidelines, efficacy, and reported side effects associated with Isotretinoin treatment in Palestine. Methods A descriptive cross-sectional online questionnaire-based study using social media platforms (eg, Facebook and Telegram) was conducted among Birzeit University students in April 2023. This study included participants aged ≥ 18 years with a history of isotretinoin treatment; subjects with incomplete data were excluded. Statistical significance was set at P < 0.05. SPSS version 27 was used for data analysis. Results A total of 548 participants were included in the study, the majority of most of whom were female (96%). The most predominant side effects were cracked, dry lips and xeroderma (96.2%). Moreover, 12% of participants had depression. Most respondents were educated about medication side effects and only 39.1% were counseled about blood donation. Of the 59 sexually active women, only 4 (6.8%) were asked for a recent pregnancy test. A total of 60.2% of dermatologists adhered to the American Academy of Dermatology (AAD) guidelines, and 48.7% ordered the required laboratory tests before initiating isotretinoin treatment. Only 1.7% of pharmacists followed the FDA-suggested protocols for dispensing isotretinoin to childbearing females. Conclusion Adherence to isotretinoin safety prescribing protocols to provide patient education, monitoring, and ordering of laboratories to ensure patient safety can be improved by adapting policies and protocols in pharmacy and medical practice in Palestine to monitor and enforce adherence when prescribing, dispensing, or taking high-risk medications.

show abstract

“…Isotretinoin has the potential to effectively treat acne, but there are many controversial opinions about this medication that are often based on insufficient data [ 15 ]. Literature indicates that there is a low level of awareness among users about the possible side effects of isotretinoin, the duration of treatment, and some instructions about the use of isotretinoin [ 16 ]. A study showed that there are no specific criteria to determine the appropriate dose of low-dose isotretinoin [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Prescribing Patterns of Isotretinoin for Acne Among Dermatologists in Central Jordan

Al-Sheyab,

Alshiyab,

Al-Shagarin

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction: Prescribing practices among dermatologists play a crucial role in managing acne, particularly concerning medications like isotretinoin. In Jordan's central region, encompassing the Governorates of Amman, Balqa, Zarqa, and Madaba, dermatologists in both public and private sectors encounter diverse cases of acne. Understanding their prescription patterns and awareness regarding isotretinoin usage is essential for optimizing acne treatment outcomes and minimizing potential risks. Methods: This study aimed to evaluate dermatologists' practices in prescribing isotretinoin for acne. It relied on the descriptive analytical approach, with the study population including all dermatologists working in the public and private sectors in the central region of Jordan. Simple random sampling was used to include 147 male and female doctors. An online questionnaire was adopted to collect data from the study sample, which was distributed through social media platforms and messaging platforms such as Facebook, WhatsApp, and Instagram to dermatologists working in the central region. Results: In this study of 147 dermatologists, 58 (39.45%) prescribed isotretinoin primarily for severe acne, and 53 (36.06%) prescribed isotretinoin to about 50-100 patients per year, with the initial dosage based on guidelines (n=102, 69.39%). The majority (n=115; 78.23%) refrained from prescribing if liver enzymes were elevated. Pregnancy tests were required by 42 (28.57%) in the first session, while 78 (53.07%) deemed it the patient's responsibility. Common precautions included sunscreen (n=77; 52.38%) and moisturizing cream (n=31, 21.09%). Only six of the dermatologists (4.08%) advised their patients not to use contact lenses, and only 17 (11.57%) prescribed moisturizing eye drops. Conclusion: This study's findings emphasize how crucial physicians' experience is when it comes to prescribing isotretinoin for severe acne. Continued educational initiatives are imperative to address gaps in patient information and safeguards in order to optimize treatment outcomes and ensure patient safety.

show abstract

Patients’ Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan

Cited by 11 publications

References 20 publications

Isotretinoin-Related Eye Dryness in Acne Patients in Qassim, Saudi Arabia

Isotretinoin-Related Eye Dryness in Acne Patients in Qassim, Saudi Arabia

Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

Prescribing Patterns of Isotretinoin for Acne Among Dermatologists in Central Jordan

Contact Info

Product

Resources

About