Historia familiar de muerte súbita por fibrilación ventricular idiopática

Dorantes, M; Marrero, Roberto; Méndez, A; Castro, Jesús; Vázquez, Alfredo

doi:10.1016/j.acmx.2013.05.007

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…The disease can present concomitantly with a variety of other congenital cardiac defects, such as bicuspid aortic valve (23% of DSS patients), ventricular septal defect (37%), and Shone's complex ( 4 , 8 , 15 ). Early diagnosis can be difficult as most patients remain asymptomatic throughout the disease ( 10 , 17 , 18 ). When present, symptoms include chest pain, heart failure, and/or syncope ( 8 , 18 ).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Early diagnosis can be difficult as most patients remain asymptomatic throughout the disease ( 10 , 17 , 18 ). When present, symptoms include chest pain, heart failure, and/or syncope ( 8 , 18 ). Nevertheless, DSS is usually revealed by the existence of both a mid-systolic and an end-diastolic murmur during physical examination.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Discrete Subaortic Stenosis: Perspective Roadmap to a Complex Disease

Massé

Shar

Brown

et al. 2018

Front. Cardiovasc. Med.

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Discrete subaortic stenosis (DSS) is a congenital heart disease that results in the formation of a fibro-membranous tissue, causing an increased pressure gradient in the left ventricular outflow tract (LVOT). While surgical resection of the membrane has shown some success in eliminating the obstruction, it poses significant risks associated with anesthesia, sternotomy, and heart bypass, and it remains associated with a high rate of recurrence. Although a genetic etiology had been initially proposed, the association between DSS and left ventricle (LV) geometrical abnormalities has provided more support to a hemodynamic etiology by which congenital or post-surgical LVOT geometric derangements could generate abnormal shear forces on the septal wall, triggering in turn a fibrotic response. Validating this hypothetical etiology and understanding the mechanobiological processes by which altered shear forces induce fibrosis in the LVOT are major knowledge gaps. This perspective paper describes the current state of knowledge of DSS, articulates the research needs to yield mechanistic insights into a significant pathologic process that is poorly understood, and proposes several strategies aimed at elucidating the potential mechanobiological synergies responsible for DSS pathogenesis. The proposed roadmap has the potential to improve DSS management by identifying early targets for prevention of the fibrotic lesion, and may also prove beneficial in other fibrotic cardiovascular diseases associated with altered flow.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Discrete Subaortic Stenosis: Perspective Roadmap to a Complex Disease

Massé

Shar

Brown

et al. 2018

Front. Cardiovasc. Med.

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“…A peak velocity that is greater than

and TPG that is greater than 80 mmHg are defined as severe SAS. However, some studies suggest that resection should only be considered in certain circumstances [ 29 , 30 ]. However, the general consensus reported in the 2008 ACC/AHA guidelines recommends surgical intervention for patients with transient echocardiographic peak gradients greater than 50 mmHg [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Effects of Subaortic Stenosis on Blood Flow Characteristics of a Mechanical Heart Valve Based on OpenFOAM Simulation

et al. 2023

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Subaortic stenosis (SAS) is a common congenital heart disease that can cause significant morbidity and mortality if not treated promptly. Patients with heart valve disease are prone to complications after replacement surgery, and the existence of SAS can accelerates disease progression, so timely diagnosis and treatment are required. However, the effects of subaortic stenosis on mechanical heart valves (MHV) are unknown. This study aimed to investigate flow characteristics in the presence of subaortic stenosis and computationally quantify the effects on the hemodynamics of MHV. Through the numerical simulation method, the flow characteristics and related parameters in the presence of SAS can be more intuitively observed. Based on its structure, there are three types of SAS: Tunnel-type SAS (TSS); Fibromuscular annulus SAS (FSS); Discrete SAS (DSS). The first numerical simulation study on different types of SAS found that there are obvious differences among them. Among them, the tunnel-type SAS formed a separated vortex structure on the tunnel-type narrow surface, which exhibits higher wall shear force at a low obstacle percentage. However, discrete SAS showed obvious differences when there was a high percentage of obstacles, forming high peak flow, high wall shear stress, and a high-intensity complex vortex. The presence of all three types of SAS results in the formation of high-velocity jets and complex vortices in front of the MHV, leading to increased shear stress and stagnation time. These hemodynamic changes significantly increase the risk of MHV dysfunction and the development of complications. Despite differences between the three types of SAS, the resultant effects on MHV hemodynamics are consistent. Therefore, early surgical intervention is warranted in SAS patients with implanted MHV.

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“…El 50% de esas arritmias ventriculares malignas, se relacionan con casos de fibrilación ventricular que van precedidas por una taquicardia ventricular que es responsable de la muerte súbita. Lo anterior, es similar con los perfiles epidemiológicos mundiales, los cuales muestran que la mayor MUERTE SÚBITA EN EL DEPORTE, PROPUESTA DE INTERVENCIÓN TEMPRANA 27 cantidad de paros cardiorrespiratorios se deben a arritmias ventriculares (14,(18)(19)(20)(21)(22) .…”

Section: Etiopatología De La Muerte Súbitaunclassified

Muerte Súbita en El Deporte, Propuesta De Intervención Temprana

Martínez

Ríos

2018

Riccafd

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Despite the low rates of occurrence, Sudden Death occurs in healthy athletes and even in high performance sports events worldwide. Its etiology is attributed mainly to cardiovascular diseases and congenital pathologies. The main objective of this article, is to compile and review specialized articles to establish the state-of-the-art in this matter. A specialized search was conducted in PubMed, Science Direct, Scielo, Redalyc and La Referencia databases, identifying 43.608 related articles, selecting 29 of them which meet certain adopted selection criteria. Finally, the main causes, symptoms and trigger factors of Sudden Death are identified and analyzed, and the procedures oriented to prevention and proper management of these events, as well as the necessary training of capabilities and skills aimed at the first respondents, are described.

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Historia familiar de muerte súbita por fibrilación ventricular idiopática

Cited by 3 publications

References 10 publications

Discrete Subaortic Stenosis: Perspective Roadmap to a Complex Disease

Discrete Subaortic Stenosis: Perspective Roadmap to a Complex Disease

Hemodynamic Effects of Subaortic Stenosis on Blood Flow Characteristics of a Mechanical Heart Valve Based on OpenFOAM Simulation

Muerte Súbita en El Deporte, Propuesta De Intervención Temprana

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