Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities

Abstract

Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported by us that rutin and cisplatin in combination show better antitumor activity against murine ascites Dalton’s lymphoma. As cisplatin is given to cancer-bearing hosts only, the present study was undertaken to explore the histoprotective effect of rutin against some toxicities induced by cisplatin in tumor-bearing mice. Cisplatin treatment caused severe damages in tissue architecture such as degenerated hepatocytes with nuclear condensation and sinusoidal dilatation in the liver, glomerular deterioration, infiltration of cells, and tubular congestion in the kidney, and vacuolization of Sertoli cells or dense granules in the cytoplasm and damaged seminiferous tubules in the testes. In the rutin plus cisplatin combination-treated mice, all the abnormal tissue architectural features were decreased. Further, as compared to cisplatin treatment, combination treatment did not show any significant elevation in the liver functional biomarkers (serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) and renal functional biomarkers (serum urea and creatinine levels). The combination treatment reduced the sperm abnormalities also as compared to the cisplatin alone treatment. The in vitro hemolysis assay of red blood cells and scanning electron microscopy revealed that combination treatment lessened the cisplatin-induced hemolysis and abnormalities in RBCs. Thus, the present findings demonstrate that rutin has histoprotective ability against cisplatin-induced toxicities in tumor-bearing mice.

Role of NF‐κB/IL‐1β Pathway and Caspase 3 in Mediating the Hepatoprotective Effect of Rutin against Paraquat‐Induced Liver Toxicity in Male Rats

“…investigated the protective effect of rutin on cisplatin‐induced toxicities in tumor‐bearing mice. The results showed that this antioxidant was able to reduce toxicities by reducing free radicals [18] . Rutin appears to be an effective antioxidant in the treatment of hepatotoxicity.…”

“…The results showed that this antioxidant was able to reduce toxicities by reducing free radicals. [18] Rutin appears to be an effective antioxidant in the treatment of hepatotoxicity. In our study, paraquat-induced hepatotoxicity decreased liver catalase and superoxide dismutase activity (Figure 1).…”

An integrated chemical analysis and network pharmacology approach to identify quality markers of Actinidia eriantha Benth radix on gastric cancer

“…The anti‐inflammatory and anti‐tumour activities of ursurane triterpenes such as asiatic acid and TEOA have been widely recognised 36–38 . Rutin and catechins are flavonoids and are widely used in cancer research 39,40 . Coumarins, including aesculin, esculetin, and 5,7‐dihydroxytryptophenone, also have anti‐inflammatory and anti‐tumour effects 41–43 .…”

“…[36][37][38] Rutin and catechins are flavonoids and are widely used in cancer research. 39,40 Coumarins, including aesculin, esculetin, and 5,7-dihydroxytryptophenone, also have antiinflammatory and anti-tumour effects. [41][42][43] Protocatechuic, ferulic, and syringic acids are phenolic acids with anti-inflammatory and antioxidant activities.…”

Evaluation of antitumor efficacy of Cerium oxide nanoparticle on Ehrlich tumour cells in mice

“…These findings also supported by the results of cisplatin group but the intensity of results were directed toward the cerium oxide nanoparticles. These results were augmented by [27 ] although these authors showed increase in GPx antioxidant Although the cisplatin is used as chemotherapy in the treatment of cancer that had excellent penetration power [28 ] but it had numerous side effects [ 29 ] that lead the pharmacist to search for another substitutes that had low tissue toxicity [ 30 ].The cisplatin accumulation encourages cellular apoptosis and cytotoxicity [31,32 ] In contrast to our work that cisplatin decreased MDA and increased SOD and showed improvements in histopathological alteration in the tumour skeletal muscle [33 ]showed increased MDA and decreased SOD and Gpx. Cisplatin also accelerated the cells to undergoes apoptotic pathway [34 ] Owing to the industry's extensive usage of cerium oxide nanoparticles [Ceo2 NPs; nanoceria (NC)] and their employment in biology and medicine, researchers have lately been interested in examining their antioxidant qualities.…”