Histoplasmosis laríngea: reporte del primer caso en Colombia

Robayo, Carlos Alberto Moriones; Ortiz, Claudia Patricia Guerra

doi:10.25100/cm.v45i4.1656

Cited by 15 publications

(7 citation statements)

References 10 publications

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“…Presence of oral ulcers is also a clinical clue towards diagnosis. We also found some rare organs involved like pericardium and vocal cords, which have been reported previously but are considered rare …”

Section: Discussionsupporting

confidence: 80%

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Bansal

Sethuraman

Gopalakrishnan

et al. 2019

Mycoses

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Summary Background Many patients with histoplasmosis are treated with anti‐tubercular therapy (ATT) in tuberculosis endemic regions as diagnosis of histoplasmosis requires invasive sampling. We sought to study the utility of urinary Histoplasma antigen detection test. Methods Case records of patients with a diagnosis of histoplasmosis prior to (Period A) and after (Period B) introduction of urinary Histoplasma antigen detection test were analysed in this single centre retrospective study. Results Thirty‐seven patients (18 in Period A, and 19 patients in Period B) were studied. There was nearly a threefold increase in diagnoses (from 0.39 cases to 1.18 cases per month) after the introduction of antigen test. Nine patients (24.3%) were immunocompromised (6 had HIV infection and 3 were on steroids), and 28 (75.6%) were immunocompetent. Empirical ATT had been given to 10 patients prior to histoplasmosis diagnosis. Invasive tissue sampling was required in only two patients in Period B to confirm the diagnosis. Immunocompromised patients were younger, were more likely to have skin and mucosal findings, anaemia and leucopenia as compared to immune‐competent patients. Conclusion This study emphasises that histoplasmosis cases may be missed and patients may receive ATT unnecessarily. Histoplasma antigen increased the diagnostic yield by almost threefold in our study.

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Section: Discussionsupporting

confidence: 80%

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Bansal

Sethuraman

Gopalakrishnan

et al. 2019

Mycoses

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“…Disseminated forms are rare, occurring mainly in children less than 2 years, elderly and immunocompromised individuals. In healthy children, this condition is usually self-limiting, rarely requiring treatment but immunocompromised children, as the present case, are prone to develop more severe disease [8]. Histoplasma capsulatum infection involving the pharynx and larynx is a rare manifestation and is usually associated with mucocutaneous form of chronic disseminated spread.…”

Section: Discussionmentioning

confidence: 71%

“…Diagnosis of laryngeal histoplasmosis is rarely based on clinical examination and a set of differential diagnosis needs to be considered like amyloidosis, tuberculosis, lymphoma, syphilis, and sarcoidosis [2,8]. Definitive diagnosis is based on histopathological examination of sputum, BAL, smears from ulcers in oral cavity, urine, bone marrow biopsies or oral/laryngeal masses with hematoxylin and eosin (H&E), periodic acid Schiff, and Gomori's methenamine-silver nitrate stain, which can be confirmed by the growth of the fungi on Sabouraudchloramphenicol medium at 27°C for 10-14 days [1].…”

Section: Discussionmentioning

confidence: 99%

Pharyngo-laryngeal histoplasmosis in an immunocompromised child—a case report

Chakravarti

Nair

Mojahid

et al. 2021

Egypt J Otolaryngol

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Background Histoplasmosis is an endemic granulomatous fungal infection which rarely infects the larynx; less than 100 cases have been reported in medical literature till date. Case presentation A 6-year-old female child, a diagnosed case of B cell acute lymphoblastic leukemia since past 2 years and on chemotherapy, presented with hoarseness and dysphagia since past 2 months. Direct laryngoscopy revealed granular appearance of posterior pharyngeal wall and the supra-glottic larynx. Histopathological examination and bone marrow aspiration confirmed the diagnosis of disseminated histoplasmosis. Conclusions Pharyngo-laryngeal histoplasmosis should be considered in the differential diagnosis of an immunocompromised patient presenting with persistent hoarseness.

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“…The vascular ectasia in this patient had extended from the proximal of esophagus to the larynx with the finding of upper airway obstruction, which could be caused by infections, structural anomalies such as laryngomalacia, congenital vocal cord paralysis, subglottic stenosis, hemangioma, or cystic hygroma. 11,12 There have been four adult cases of vascular ectasia in esophagus reported in the literature. The case presented here is the first pediatric case of vascular ectasia accompanied with submicroscopic chromosomal anomalies.…”

Section: Discussionmentioning

confidence: 99%

A Two-Month-Old Child with Vascular Ectasia: A Case Report Diagnosed by Molecular Karyotyping

et al. 2018

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Gastrointestinal angiodysplasia can be encountered in cases with aortic stenosis, inflammatory gastrointestinal conditions, von Willebrand disease or vascular damage, and degenerative changes. Predisposing factors have been described in four adults with vascular ectasia located in the stomach, duodenum, and the distal esophagus. Here, we report a 2-month-old infant with vascular ectasia in the proximal esophagus and diagnosed by molecular karyotyping. This is the first case of vascular ectasia in the proximal esophagus in a pediatric patient.

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Histoplasmosis laríngea: reporte del primer caso en Colombia

Cited by 15 publications

References 10 publications

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Pharyngo-laryngeal histoplasmosis in an immunocompromised child—a case report

A Two-Month-Old Child with Vascular Ectasia: A Case Report Diagnosed by Molecular Karyotyping

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