Histoplasma capsulatum Endocarditis

Blair, Timothy P.; Raymond, Lawrence W.

doi:10.1378/chest.79.6.620

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Physical examination is remarkable for fever (96%), heart murmur (76%), hepatomegaly or splenomegaly (48%) petechiae (35%), and/or major artery embolization (32-53%). 41 Isolated valvular infection is seen, but more than 70% of cases occur in the setting of widely disseminated histoplasmosis (i.e. infection in two or more extra-cardiac sites or in bone marrow).…”

Section: Discussionmentioning

confidence: 99%

Histoplasma endocarditis: clinical and mycologic features and outcomes

Bhatti

Vilenski

Tight

et al. 2005

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Histoplasma endocarditis: clinical and mycologic features and outcomes

Bhatti

Vilenski

Tight

et al. 2005

Journal of Infection

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“…However, our patient had both chronic progressive disseminated histoplasmosis and Histoplasma infective endocarditis. Both entities are rarely encountered manifestations of disseminated Histoplasma infection and are predominantly described in apparently immunocompetent hosts (2,3). Their presentation is often non-specific with constitutional symptoms.…”

Section: Discussionmentioning

confidence: 99%

Progressive disseminated histoplasmosis in an apparently immunocompetent patient with a bioprosthetic aortic valve

Lieu

Parkes

Longtin

et al. 2020

Official Journal of the Association of Medical Microbiology and

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Histoplasma capsulatum is an endemic fungus in eastern Canada. This organism has a wide spectrum of manifestations ranging from isolated pulmonary to disseminated disease. The latter usually occurs in immunocompromised hosts or those with substantial environmental exposure. In rare instances, disseminated histoplasmosis can present as an endovascular infection or chronic progressive disseminated histoplasmosis. If not recognized, these entities are almost uniformly fatal. We report a case of an immunocompetent man with a history of longstanding constitutional symptoms. An infectious cause was initially presumed to be unlikely given the chronic nature of his presentation and an extensive series of negative investigations. A diagnosis was only obtained post-mortem upon the unusual detection of both yeast and hyphal forms in blood culture bottles inoculated with a bone marrow aspirate.

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“…[3][4][5][6][7] Acute granulomatous histoplasmosis involving the endocardium and/or myocardium is rare. [8][9][10] We provide a detailed description of a severe form of pulmonary histoplasmosis complicated by granulomatous endocarditis involving the free wall of the right ventricle.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Histoplasmosis Complicated by Nonvalvular Right Ventricular Wall Histoplasma capsulatum Endocarditis

et al. 2023

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Histoplasmosis is commonly a self-limited fungal disease that primarily affects the lung and reticuloendothelial system. Cardiac involvement by histoplasmosis is uncommon. In this report, we provide a detailed description of severe pulmonary histoplasmosis complicated by the disease involvement of the free wall of the right ventricle. A 55-year-old female presented with cough, fevers, dyspnea, and 30-pound unintentional weight loss in 6 months. Her past medical history was significant for supraventricular tachycardia with permanent pacemaker implantation. Imaging studies revealed an intracardiac mass accompanied by mediastinal lymphadenopathy and bilateral lung nodules. Endobronchial ultrasound-guided transbronchial needle aspiration of station 4R lymph nodes revealed numerous yeast forms, morphologically consistent with Histoplasma capsulatum. The diagnosis was further corroborated by the elevated titers of serum antibodies against Histoplasma capsulatum. The right ventricular mass debulking with biopsy showed necrotizing granulomatous inflammation involving nonvalvular endocardium and myocardium of the free wall of the right ventricle. The report documents an unusual presentation of pulmonary histoplasmosis accompanied by nonvalvular endocarditis and suggests a possible association between the site of the cardiac infection and the presence of a permanent intravascular pacer device.

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Histoplasma capsulatum Endocarditis

Cited by 6 publications

References 2 publications

Histoplasma endocarditis: clinical and mycologic features and outcomes

Histoplasma endocarditis: clinical and mycologic features and outcomes

Progressive disseminated histoplasmosis in an apparently immunocompetent patient with a bioprosthetic aortic valve

Pulmonary Histoplasmosis Complicated by Nonvalvular Right Ventricular Wall Histoplasma capsulatum Endocarditis

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