Histopatologi serta Aktivitas Hati Kelinci Lokal (Lepus sp.) yang Diberi Ransum Tepung Daun Kaliandra (Calliandra calothyrsus Meissn.) dan Kulit Nanas (Ananas comosus L.)

Abstract

The aimed of this study was to determine the effect of feed containing various concentrations of Calliandra calothyrsus Meissn. leaf meal mixed with pineapple peels and concentrate feed on histopathology and the activity of liver of local rabbit (Lepus sp). This study used a Post-Test Only Control Group Design, using 24 local male rabbits divided into 4 groups of feed treatment namely P0 = concentrate feed as control; P1 = mixture of 15% of calliandra leaf meal (CLM), 30% of pineapple peels (PP) and 55% of commercial feed (CF); P2 = 30% of CLM, 30% of PP and 40% of CF; and P3 = 45% of CLM, 30% of PP and 25% of CF). The treatments were given for 60 days and used 6 replicates for each group. The data were analyzed statistically by SPSS program version 22. The research results showed the increase of calliandra leaf meal levels in concentrated feed which were added 30% of pineapple peels still caused liver damage namely fatty degeneration, necrosis and congestion. It increased the ALT level, but did not affect the AST level in local rabbit serum.

The addition of papaya seed flour (Carica papaya) to the growth of ‘Cantang’ hybrid grouper fish (Epinephelus fuscoguttatus >< Epinephelus lanceolatus)

“…Feeds that contain excess tannins can cause liver damage due to increased oxidative levels in organs. Wiranatha et al (2019) also found long-term exposure to many tannins damages the cells, in which tannins become harmful nutrients.…”

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Hepatoprotektor Rumput Laut Eucheuma cottonii Pada Tikus Putih (Rattus norvegicus L.) Jantan Yang Diinduksi Natrium Nitrit (Nano2)

“…Semua penyusun sel akan keluar menuju sistem peredaran darah sehingga sel mengalami nekrosis. Apabila nekrosis tersebut terjadi pada hepatosit, akan menyebabkan keluarnya enzim SGOT dan SGPT menuju sistem peredaran darah sehingga kadarnya menjadi tinggi di dalam darah (Wiranatha et al, 2019).…”