Histopatologi Hepar Tikus Wistar (Rattus norvegicus) Jantan setelah Pemberian Teh Kombucha Konsentrasi 100% dengan Waktu Fermentasi yang Berbeda

Nugraha, Agung Putra; Isdadiyanto, Sri; Tana, Silvana

doi:10.14710/baf.3.1.2018.71-78

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Hepar adalah organ yang berfungsi dalam pengaturan berbagai metabolisme dan detoksifikasi racun di dalam tubuh (Treuting et al, 2012). Hepar sering mengalami gangguan atau kerusakan karena fungsinya yang sangat vital (Nugraha et al, 2018). Ketika zat toksik masuk ke dalam tubuh secara terus menerus dan dalam jangka panjang, maka hepatosit akan mengalami penurunan kemampuan regenerasi hingga menyebabkan kematian sel (Sijid et al, 2020).…”

Section: Pendahuluanunclassified

Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma longa L.) terhadap Histologi Hepar Tikus Pasca Diinduksi Thioacetamide (TAA)

Utami¹,

Aqlina²,

Fajariyah³

et al. 2022

Bioscientist j. ilm. bosbiol.

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Turmeric (Curcuma longa L.) rhizome contains antioxidant compounds that can prevent damage to the liver. Thioacetamide (TAA) is an organosulfur compound in the form of crystals and is widely used as a fungicide and organic solvent in the textile, leather and paper industries, as well as being used as a motor fuel stabilizer. Continuous exposure to TAA compounds can cause hepatocyte damage in the form of parenchymatous degeneration and necrosis. The purpose of this study was to determine the effect of turmeric (Curcuma longa L.) rhizome extract on the histological appearance of the rat (Rattus norvegicus) liver after being induced by TAA. This study used a completely randomized design (CRD) with 24 Wistar rats (Rattus norvegicus) which were divided into 4 groups, namely: K- (no treatment), K+ (TAA induced 200 mg/kg BW), D1 (TAA induced 200 mg/kg BW + administration of turmeric rhizome extract at a dose of 200 mg/kg BW), and D2 (TAA induction of 200 mg/kg BW + turmeric rhizome extract at a dose of 400 mg/kg BW). TAA induction was carried out intraperitoneally, while administration of turmeric rhizome extract was carried out by gavage. Preparation of liver histology preparations using the paraffin method and Hematoxylin Eosin (HE) staining to see liver damage including parenchymatous degeneration and necrosis. The results showed that administration of turmeric rhizome extract doses of 200 mg/kg BW and 400 mg/kg BW had a significant effect on decreasing the average number of hepatocytes undergoing parenchymatous degeneration and necrosis after being induced by TAA at a dose of 200 mg/kg BW.

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Section: Pendahuluanunclassified

Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma longa L.) terhadap Histologi Hepar Tikus Pasca Diinduksi Thioacetamide (TAA)

Utami¹,

Aqlina²,

Fajariyah³

et al. 2022

Bioscientist j. ilm. bosbiol.

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“…The liver is the largest organ in the human body which has an important role in the processes of metabolism, secretion, synthesis, and detoxification (Muhartono et al, 2019). The role of the liver in detoxification causes the liver to be vulnerable to damage cell structures that can interfere with liver function (Nugraha et al, 2018) (Werdhasari, 2014). Periwinkle is a plant that contains flavonoid compounds, alkaloids, and quinones that act as antioxidant compounds (Kristanto et al, 2004).…”

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confidence: 99%

Effect of Periwinkle (Catharanthus Roseus) Leaf Extract on Liver Histology of Mice (Mus Musculus L) After Aspartame Induce

Mahriani

Wulandari

Fajariyah

2022

BIOLINK

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Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of periwinkle leaves (Catharanthus roseus L) on aspartame-induced liver histology. This study used 24 male mice divided into 4 groups, namely negative control (K-) without treatment; Positive control (K +) treatment of aspartame; D1: treatment of aspartame and periwinkle extract doses of 0.42 mg/kg. D2: aspartame and periwinkle extract doses of 0.84 mg/kgbb. Administration of aspartame dose of 0.2 mg /kgbb by intraperitoneal for 14 days followed by gavage administration of periwinkle leaf extract for 12 days. The liver was taken on the 27th day by surgery, then made slide histology with Hematoxylin-Eosin staining. The results show that the administration of Catharanthus roseus leaf extract at a dose of 0.84 mg/kgbw in aspartame-induced mice was effective in reducing hepatocyte damage, namely hydrophilic degeneration and necrosis.

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The Effectiveness of Boiled Rosy Periwinkle (Catharanthus roseus) in Decreasing SGOT and SGPT Value of Male Wistar Strain Rats with Acute Hepatitis Model

Zai

Sudharmono

2019

isc

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Acute hepatitis is a disease that attacks the liver and causes inflammation in the liver cells which is characterized by swelling, damage, death, and even disruption of liver function, so that it can result in increased values of Serum Glutamic Pyruvic Oxaloactic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). This study aims to determine the effectiveness of the Rosy Periwinkle (Catharanthus roseus) on decreasing SGOT and SGPT level. The object of this research is 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams which were adapted for 7 days. The object of this study was divided into 3 groups, namely the treatment group, the positive control group and the negative control group. The treatment group and positive control group were induced Paracetamol 120 mg / day orally for 7 days. 5.2 grams of boiled Rosy Periwinkle (Catharanthus roseus) as much as 3.6 cc orally for 7 days was given to the treatment group. Data were analyzed with SPSS version 24, One Way ANOVA test to compare SGOT and SGPT values. The results of this study found that there were a significant difference in the SGOT value between the treatment group, the positive control group and the negative control group (p <0.05) and there were significant differences in the SGPT value between the treatment group and the positive control group (p <0.05) . The conclusion of this study is that the boiled Rosy Periwinkle (Catharanthus roseus) has an effect on the decrease in SGOT and SGPT values in male wistar strain Rats with acute hepatitis model.

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Histopatologi Hepar Tikus Wistar (Rattus norvegicus) Jantan setelah Pemberian Teh Kombucha Konsentrasi 100% dengan Waktu Fermentasi yang Berbeda

Cited by 3 publications

References 4 publications

Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma longa L.) terhadap Histologi Hepar Tikus Pasca Diinduksi Thioacetamide (TAA)

Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma longa L.) terhadap Histologi Hepar Tikus Pasca Diinduksi Thioacetamide (TAA)

Effect of Periwinkle (Catharanthus Roseus) Leaf Extract on Liver Histology of Mice (Mus Musculus L) After Aspartame Induce

The Effectiveness of Boiled Rosy Periwinkle (Catharanthus roseus) in Decreasing SGOT and SGPT Value of Male Wistar Strain Rats with Acute Hepatitis Model

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