The objective of this study was to analyze the effect of neem leaf ethanol extract as an herbal antihyperlipidemia agent on white rats induced by high fat ration. The white rat used was male Wistar strain with 2 months of age and average body weight of approximately 200 grams. The rats were divided into 6 groups of 4, namely: Negative control (P0) was given commercial ration, positive control (P1) was given high fat ration and duck egg yolk per oral 2.5 ml / g BW, P2 was given high fat ration and duck egg yolk per oral 2.5 ml / 200 g BW + 8 mg / g BW simvastatin in 1 ml of distilled water, P3 was given high-fat ration and duck egg yolk orally 2.5 ml / 200 g BW + 75 mg / g BW ethanol extract of neem leaf in 1 ml of distilled water, P4 was given high fat ration and duck egg yolk per oral 2.5 ml / 200 g BW + 100 mg / g BW ethanol extract of neem leaf in 1 ml of distilled water, and P5 was given high fat ration and duck egg yolk per oral 2.5 ml / 200 g BW + 125 mg / g BW ethanol extract of neem leaf in 1 ml of distilled water. The variables observed were total cholesterol, HDL, LDL and TG levels. Data were analyzed using ANOVA followed by Least Significant Difference (LSD) test with 95% confidence level using SPSS 10.0 software. The results showed that administration of the ethanol extract of neem leaf (A. indica) can raise levels of HDL, lowering levels of LDL cholesterol and TG in blood serum of white rats (Rattus norvegicus L.).
People's concern about quail egg consumption has triggered the efforts to produce quail eggs with low cholesterol content by using organic feed. Organic feed is one type of feed rations made of mixing organic material. In this study, standard organic feed (rice bran, yellow corn, soybean, and fishmeal) and organic feed containing mackerel, cassava leaves, and turmeric powder was administere to female japanese quail. Organic feed containing mackerel, cassava leaves, and turmeric powder can affect the Japanese quail (Coturnix coturnix japonica L.) lipid profile. This research used experimental methods. Twenty-seven female Japanese quails were divided into 3 treatment groups (PO: commercial feed, P1: standard organic feed, P2: feed containing organic turmeric powder, cassava leaves, and mackerel) for 145 days with 9 repeat. Data obtained were in the form of average daily feed intake and blood lipid profiles of each treatment group. Further data analysis was performed by analysis of variance (ANOVA) followed by Duncan test. The results showed that administration of organic feed containing mackerel, cassava leaves, and turmeric powder can reduce the levels of cholesterol, triglycerides, and LDL but increase the HDL levels in Japanese quail. Supplementation of turmeric powder improve the chemical quality of Japanese quail eggs, so it is good for the development of quail embryos as well as for consumption. It can be concluded that organic feed and turmeric powder supplementation stabilize blood lipid profile and improve the reproduction of Japanese quail egg low cholesterol, so good for the development of embryo quail and for consumption.
Antihyperglycemic effect of Sesbania grandiflora seed decoction on streptozotocin-induced diabetic mice: Inflammatory status and the role of interleukin-10 AIP Conference Proceedings 1844, 020015 (2017) Abstract. This research was conducted to determine the effect of ethanolic leaf extract of Azadirachta indica (Neem) on plasma estradiol 17-β synthesis in mice. Thirty virgin female mice (Swiss Webster strain) between 2.5 and 3 months old (25 ± 2.5 g body weight) were used as the experimental sample. The mice were divided into five groups: K-group were administered tap water; K+ group were administered contraceptive pills; P1 to P3 group were administered orally with ethanolic A. indica leaf extract at doses of 8.4, 11.2, and 14 mg/animal/day, respectively. The regularity of the estrous cycle was monitored during treatment. The mice were sacrificed after being treated orally for 21 days and blood was collected by cardiac puncture under chloroform anesthesia. The estradiol concentration was measured by ELISA. Ovaries were processed with the paraffin method and HE staining. Our results showed that the estrous cycle irregularity of treated groups was higher than K-group. The estradiol concentration was significantly different (p<0.05) compared to the control group (25.02 ± 1.16 pg/mL in the control group and 18.86 ± 2.21 pg/mL in treated group but there was no significant difference (p>0.05) between the treated groups. The atresia follicle number was significantly different (p<0.05), not compared to the control group but between treated groups also. It can be concluded that Neem extracts disrupt the estradiol 17-β concentration by interference with follicle development in the ovaries so that the regularity of estrous cycle was disrupted.
Heparin, an active sulfate group material, grafted onto blend membrane citric acid cross-linked chitosan/poly (vinyl alcohol)-poly(ethylene glycol) (PVA-PEG) to improve the membrane properties. The physical tests shown that grafting reaction of citric acid crosslinked chitosan increased the mechanical strength and membrane swelling. The permeability test results, it was found that the grafted chitosan membrane was improved permeability of both urea and creatinine as compared to chitosan pure and chitosan crosslinked membrane. The negative charge of the sulphonate group of heparin increased the number of the active side of the carrier in the membrane, which then correlated to the membrane’s permeability process.
Organic quail eggs contain high nutrients and low cholesterol, so it is needed in the process of hematopoiesis that occurs in the bone marrow. The purpose of this study was to determine hematological status of rat (Rattus norvegicus L.) in the period of lactation after supplementation of organic quail eggs. This study is an experimental study using a completely randomized design with 4 treatments and 5 replications. Some treatments applied are: T0: Control; T1: The lactation period of (Rattus norvegicus L.) with giving quail eggs supplement of commercial feed; T2: The lactation period of (Rattus norvegicus L.) with giving quail eggs supplement of standard organic feed; T3: The lactation period of (Rattus norvegicus L.) with giving quail eggs supplement of given organic feed. The results showed that feed intake, weight femur, long bone of the femur, erythrocytes, and hemoglobin levels were not significantly different (p > 0.05), blood pH significantly different (p < 0.05). Supplementation of organic quail eggs could be maintain the condition hematological status of erythrocytes, hemoglobin and blood pH in the lactation period of (Rattus norvegicus L.).
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