Histopathology of ultrashort-laser-pulse retinal damage

Toth, Cynthia A.; Narayan, Drew G.; Osborne, Catherine; Rockwell, Benjamin A.; Stein, Cindy D.; Amnotte, Rodney E.; DiCarlo, Cheryl Dawn; Roach, William P.; Noojin, Gary D.; Cain, Clarence P.

doi:10.1117/12.239598

Cited by 2 publications

(2 citation statements)

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“…18 At longer pulse durations, the MVL threshold occurs far below the LIB threshold. Recently, interesting histological 28 and physical 18,29 evidence has been presented which may lend further credence to the theory of damage mediated by LIB.…”

Section: Laser-induced Breakdownmentioning

confidence: 75%

Artificial eye for in vitro experiments of laser light interaction with aqueous media

Cain¹,

Noojin

Hammer

et al. 1997

J. Biomed. Opt.

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An artificial eye has been designed and assembled that mimics the focusing geometry of the living eye. The artificial eye's focusing characteristics are measured and compared with those of the in vivo system. The artificial eye is used to measure several nonlinear optical phenomena that may have an impact on the laser damage thresholds of the retina produced by ultrashort laser pulses. We chose a focal length of 17 mm to simulate the rhesus monkey eye, with a visual cone angle of 8.4 deg for a 2.5-mm diameter laser beam input. The measured focal point image diameter was 5.6Ϯ1 m, which was 1.5 times the calculated diffractionlimited image diameter. This focusing system had the best M 2 of all the systems evaluated. We used the artificial eye to measure the threshold for laser-induced breakdown, stimulated Brillouin scattering, supercontinuum generation, and pulse temporal broadening due to group velocity dispersion.

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Section: Laser-induced Breakdownmentioning

confidence: 75%

Artificial eye for in vitro experiments of laser light interaction with aqueous media

Cain¹,

Noojin

Hammer

et al. 1997

J. Biomed. Opt.

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“…Our group has pursued the goal of understanding light propagation, 2 3 heat transfer, and a number of damage mechanisms [4][5][6] in both the eye and skin. Recently, we have focused on revisions of ANSI infrared exposure limits to more accurately reflect the trends in biological response.…”

Section: Introductionmentioning

confidence: 99%

Modeling of surface thermodynamics and damage thresholds in the IR and THz regime

et al. 2007

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The Air Force Research Lab has developed a configurable, two-dimensional, thermal model to predict laser-tissue interactions, and to aid in predictive studies for safe exposure limits. The model employs a finite-difference, time-dependent method to solve the two-dimensional cylindrical heat equation (radial and axial) in a biological system construct. Tissues are represented as multi-layer structures, with optical and thermal properties defined for each layer, are homogeneous throughout the layer. Multiple methods for computing the source term for the heat equation have been implemented, including simple linear absorption definitions and full beam propagation through finite-difference methods.The model predicts the occurrence of thermal damage sustained by the tissue, and can also determine damage thresholds for total optical power delivered to the tissue. Currently, the surface boundary conditions incorporate energy loss through free convection, surface radiation, and evaporative cooling. Implementing these boundary conditions is critical for correctly calculating the surface temperature of the tissue, and, therefore, damage thresholds. We present an analysis of the interplay between surface boundary conditions, ambient conditions, and blood perfusion within tissues.

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Histopathology of ultrashort-laser-pulse retinal damage

Cited by 2 publications

References 1 publication

Artificial eye for in vitro experiments of laser light interaction with aqueous media

Artificial eye for in vitro experiments of laser light interaction with aqueous media

Modeling of surface thermodynamics and damage thresholds in the IR and THz regime

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