Histopathology Findings in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Canil, Ammiel Martínez; Iossa, Angelo; Termine, Pietro; Caporilli, Daniela; Petrozza, Vincenzo; Silecchia, Gianfranço

doi:10.1007/s11695-017-3092-9

Cited by 32 publications

(18 citation statements)

References 34 publications

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“…Generally, pre-malignant lesions identified in LSG specimens across 11 studies varied from 4.1 to 33.2% [10,18,[36][37][38][39][40][41][42][43][44]. However, across these 11 abovementioned studies, there was zero actual malignancy reported, despite that these studies were undertaken in a wide variety of geographical areas worldwide with different risk of gastric cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, even with our 7.5% pre-malignant lesions identified in LSG specimens, and with the huge number of LSG procedures undertaken worldwide, such current lack of the evidence base renders us unable to extrapolate in any way the potential number of patients with pre-malignant lesions that would actually turn malignant or whether such numbers would be high and alarming or otherwise. Hence, there exists much debate regarding the role of routine histopathological examination of LSG specimens [10,18,[36][37][38][39][40][41][42][43][44], and some authors have suggested that histopathological examination of LSG specimens is to be done when intraoperative macroscopic pathology is observed [10,18,43]. Future research would benefit from addressing these points.…”

Section: Discussionmentioning

confidence: 99%

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Compared to What? Is BMI Associated with Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens?

2019

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Background Obesity is a risk for many different cancers. Laparoscopic sleeve gastrectomy (LSG) is common, and benign or premalignant histopathology types are reported in the removed gastric specimens. We assessed whether higher BMI was associated with certain benign or pre-malignant histopathological changes. Method Retrospective chart review of all primary LSG patients (N = 1555). Demographic, clinical, and LSG histopathology data were retrieved. BMI of patients with specific benign or pre-malignant conditions in their gastric specimens was compared with the BMI of the rest of the patients with abnormal histopathology specimens and also compared with the BMI of patients with normal control specimens.Results Females comprised 70% of the patients. Mean BMI were 46.3 (females) and 48 (males). Normal LSG specimens comprised 52%. Most common abnormal histopathologies were chronic inactive gastritis (33%), chronic active gastritis (6.8%), follicular gastritis (2.7%), lymphoid aggregates (2.2%), intestinal metaplasia (1.4%) and GIST (0.7%). After controlling for confounders (age, gender, H. pylori, diabetes mellitus type 2, hypertension), no significant association was observed between the BMI of patients with specific benign or pre-malignant histopathology compared with the BMI of the rest of the patients with abnormal histopathologies and compared to the BMI of patients with normal histopathologies. Conclusion When confounders were taken into account, there appeared no significant associations between the BMI of patients with specific benign or pre-malignant histopathology compared with the BMI of the rest of the patients with abnormal histopathologies and compared to the BMI of patients with normal histopathologies of their gastric specimens. There was a very weak correlation between BMI and other covariates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Compared to What? Is BMI Associated with Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens?

2019

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“…These patients need to be followed up strictly. Intestinal metaplasia can be detected at a rate of 0.2-5% and atrophic gastritis with a rate of 0.2-1.8% (Canil et al, 2018;Almazeedi et al, 2013). In our series, low-grade dysplasia was seen in 2 (0.5%) patients, intestinal metaplasia in 17 (4.1%), and atrophic gastritis in 1 (0.5%).…”

Section: Discussionmentioning

confidence: 41%

“…In the specimen, there were 200 (48.7) patients with signs of Helicobacter pylori-associated gastritis. Dysplasia can be seen at a rate of 0.06-0.2% in the histopathological examination of sleeve gastrectomy specimens (Canil et al, 2018;Safaan et al, 2017). These patients need to be followed up strictly.…”

Section: Discussionmentioning

confidence: 99%

Histopathological findings of gastric specimens of patients undergoing sleeve gastrectomy

Uylaş¹,

Gündoğdu²,

Çiçek³

et al. 2021

JECM

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Sleeve gastrectomy is the most preferred surgical procedure in obese patients. In the literature, the necessity of pathological examination of the specimen is emphasized because of malignant case reports. In this study, we aimed to present the histopathological findings of the specimens of our patients who underwent sleeve gastrectomy due to obesity in the light of the literature. Patients who underwent sleeve gastrectomy due to obesity between 2014-2019 in our clinic were retrospectively screened. Endoscopy was not performed in patients with no symptoms. After the obesity committee, the patients were operated and the specimens were sent for routine histopathological examination. Patients' age, gender, body mass index, surgical procedure information, and histopathological features of resected gastric specimens were analyzed. A total of 411 patients were included in the study and there were 309 (75.2%) female patients. The overall mean age was 35 ± 10.3 and the mean body mass index was 44.7 ± 5.2 kg / m2. The pathology of 85 (20.7%) of the patients were reported as completely normal. Abnormal pathological findings were detected in 326 (79.3%) patients. No malignant finding was found in the specimen pathology results. The necessity of endoscopic examination before sleeve gastrectomy is controversial. Even if no malignant pathological result was detected in our study, we believe that routine pathological examination is required for medicolegal reasons.

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“…Secondly, the current study reported positive significant correlation between BMI at time of enrollment and positivity for Hp. In support of such correlation, Hansen et al (29) detected a statistically significant association between preoperative Hp and significantly abnormal pathology detected in gastric sleeve excised specimens in obese patients and Canil et al (30) detected Hp in 24.6% of preoperative endoscopic gastric biopsy obtained from morbidly obese patients assigned for laparoscopic gastric sle eve surgery. Also, Šebunova et al (31) found about two-thirds of morbidly obese patients undergoing bariatric surgery are infected with Hp with a high prevalence of virulence genes and recommended treatment of this infection before surgery.…”

Section: Discussionmentioning

confidence: 90%

Obesity, Helicobacter pylori Infection and Preeclampsia: A triangle of Danger for pregnant women Running title: Helicobacter pylori Infection and Preeclampsia.

Shedid¹,

Mourad

2018

The Egypt. J. of Fert.y of Steri.

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Objectives:To determine the frequency of Helicobacter pylori (Hp) infection among primigravida and its relation to development of preeclampsia (PE). Patients and Methods:This cohort study included 146 primigravida evaluated prior to the 12th week gestational age, women who developed PE were categorized as PE group and a similar number of pregnant women free of hypertensive manifestations as control (No PE) group. All patients were evaluated for age and body mass index (BMI) and underwent Hp diagnosis workup including Urea breath test and Hp stool antigen testing.Results: Twenty-six women developed early and 47 developed late PE and 52 had mild, while 21 had severe PE. Development and severity of PE showed positive significant correlation with BMI. Sixty patients were Hp+; blood pressure measures at time of development of PE were significantly higher in Hp+ than in Hp-patients, irrespective of developing PE. Blood pressure measures and BMI showed positive significant correlation with Hp positivity. Statistical analysis defined high BMI as the significant independent predictor for development of PE. Conclusion:High BMI may underlie the development and severity of PE and is associated with Hp infection.

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Histopathology Findings in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Cited by 32 publications

References 34 publications

Compared to What? Is BMI Associated with Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens?

Compared to What? Is BMI Associated with Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens?

Histopathological findings of gastric specimens of patients undergoing sleeve gastrectomy

Obesity, Helicobacter pylori Infection and Preeclampsia: A triangle of Danger for pregnant women Running title: Helicobacter pylori Infection and Preeclampsia.

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