Histopathology effects of nickel nanoparticles on lungs, liver, and spleen tissues in male mice

Abstract

Because of the classification of the nickel compounds as carcinogenic substances, there is a need for in vivo tests to nickel nanoparticles (NiNPs) for observing their effects on health experimentally. Spherical NiNPs with 10 nm in diameter and 75 ppm concentration were applied for investigating their toxicities within male albino mice as an in vivo model. We randomly made sham group, control group, and 75 ppm group (with five animals in each group). Then, the nanoparticles were injected into mice intraperitonealy for 7 days and after that their lungs, liver, and spleen were removed for histopathological observations. At the end of the test, section microscopic observations of liver, spleen, and lung in sham and control groups showed normal tissues but these tissues underwent significant abnormal effects in 75 ppm group. NiNPs can cause undesirable effects in lungs, liver, and spleen tissues with same condition of this study.

Paclitaxel/Chitosan Nanosupensions Provide Enhanced Intravesical Bladder Cancer Therapy with Sustained and Prolonged Delivery of Paclitaxel

“…After intravesical instillation chemotherapy, the PTX/CS blends, and PTX/CS NSs showed prolonged survival and the survival rate of PTX/CS NSs was the highest (Figure B). Many researchers have reported that the nanomaterials tend to accumulate in liver and kidney because the liver and kidney are the main detoxifying organs. − Therefore, it is very important to examine the influence of PTX/CS NSs on liver and kidney function. The blood clinical chemistry level measuring is a simple and reliable indication of kidney and liver health.…”

Nickel nanoparticles induce hepatotoxicity via oxidative and nitrative stress-mediated apoptosis and inflammation

“…The histopathological analysis marked liver congestion, steatosis, zonal necrosis, and inflammatory cell infiltration in portal vein areas after Ni NP exposure. The increased bilirubin may lead to hyperbilirubinemia and cholestasis that is coupled with an increased level of ALP and AST that induces liver necrosis at zonal areas owing to obstruction of bile ducts and infiltration of excessive bile in the portal and central vein that leads to necrosis (Magaye et al, 2014; Alarifi et al, 2013; Ajdari and Marziyeh, 2014). The nanoparticles are entered into the blood and reach the target organs where NPs induce necrosis owing to changes in various biochemical biomarkers that increase the cellular pressure because of electrolyte imbalance and cause dose-dependent abnormalities in histoarchitecture (Nel et al, 2006).…”

Detection of Macro and Micro Nodule Using Online Region Based-Active Contour Model in Histopathological Liver Cirrhosis

“…Ajdari, and M.Z. Ghahnavieh, [14] have investigate the histopathology effects of Nickel Nano-particles (NiNPs) on the lungs, liver and spleen tissues in male mice. The histopathologic investigation result showed that the low to high abnormalities in the liver, spleen, and lung tissues were treated in mice by employing Ni-NPs.…”