Histopathology and Ultrastructure of the Argon Laser Lesion in Human Retinal and Choroidal Vasculatures

Apple, David J.; Goldberg, Morton F.; Wyhinny, George J.

doi:10.1016/0002-9394(73)90812-x

Cited by 90 publications

(27 citation statements)

References 6 publications

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“…The extent of retinal and choroidal damage is similar to that seen in prior CW laser studies in which a thermal damage mechanism was implicated in retinal lesion formation [16][17][18]. Within this limited study there was no apparent risk of rupture of Bruch's membrane in acute, higherenergy, mode-locked lesions when compared to the CW lesions of similar energy.…”

Section: Resultssupporting

confidence: 65%

A Comparative study of retinal effects from continuous wave and femtosecond mode‐locked lasers

Thomas¹,

Noojin²,

Stolarski³

et al. 2002

Lasers Surg Med

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Section: Resultssupporting

confidence: 65%

A Comparative study of retinal effects from continuous wave and femtosecond mode‐locked lasers

Thomas¹,

Noojin²,

Stolarski³

et al. 2002

Lasers Surg Med

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“…Related studies have indicated that (1) repetitive applica¬ tions of laser burns of sufficient energy can produce obliteration of small von Hippel-Lindau angiomas, as well as occlusion of small and medi¬ um-sized arterioles7; and (2) that repetitive laser burns to the same site may occlude small clusters of normal intraretinal capillaries.8 However, extrapolation of these findings to the pathologic surface NVE secondary to proliferative diabetic retinopathy have not been made prior to our report.…”

Section: Clinical Observationscontrasting

confidence: 46%

Histopathology of Focally Photocoagulated Preretinal New Vessels

Wallow¹,

Skuta²

1984

Archives of Ophthalmology

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“…Drusen bei fokaler Laserbehandlung im Makulabereich kommt, war Anlass, diesen Effekt kontrolliert zu untersuchen [1,9,11,19,24,29,30] …”

Section: Beobachtung Dass Es Zur Beschleunigten Resorption Vonunclassified

Langzeiteffekt und Sicherheit der fokalen Laserkoagulation bilateraler Drusen bei altersbedingter Makuladegeneration

Tittl

Maár

Stur

1999

Spektrum Augeheilkd

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Zusammenfassung. Die fokale Laserkoagulation bilateraler Drusen zur Prophylaxe einer schweren Sehbehinderung durch fortgeschrittene altersbedingte Makuladegeneration ist ein neues therapeutisches Konzept, das auf seine Wirksamkeit and Sicherheit im Langzeitverlauf uberpruft werden muss. Zu diesem Zweck wurde in einer Pilotstudie ein homogenes Kollektiv von zehn konsekutiven Patienten an einem Auge standardisiert behandelt. Die Partneraugen fungierten als Kontrollgruppe. Nach einer medianen Nachbeobachtungsdauer von 3,9 Jahren wies die Behandlungsgruppe im Bezug zur Kontrollgruppe eine um 0,6 Zeilen geringere Visusreduktion (p = 0,2) and eine signifikante Reduktion der Drusenflache (p = 0,04) auf. 77,8% der behandelten Augen hatten sichtbare Zeichen einer Drusenresorption. In der Behandlungsgruppe entwickelte kein Auge eine Komplikation im Sinne einer atrophen oder neovaskularen Makulopathie. Im Gegensatz dazu entstand in einem (11,1%) von 9 Augen der Kontrollgruppe eine choroidale Neovaskularisation. Die hier vorliegenden Ergebnisse belegen die potentielle Wirksamkeit and nachhaltende Sicherheit der fokalen Laserkoagulation von bilateralen Drusen in Rahmen der altersbedingten Makuladegeneration.Schlasselworter: Altersbedingte Makuladegeneration, Drusen, Lasertherapie, prophylaktische Therapie.Long-term effect and safety of focal laser coagulation of bilateral drusen in age-related macular degeneration Summary. The prophylactic laser treatment of bilateral early age-related macular degeneration induces accelerated regression of macular drusen. To assess the therapeutic effect on retinal morphology and visual function, we conducted a pilot study with 20 eyes of 10 consecutive patients. The median time of follow-up was 3,9 years. In comparison to the untreated partner-eyes, the treated eyes showed a, although insignificant, minor loss of visual acuity of 1,4 versus 0,8 lines on the ETDRS-chart. Regression of drusen area was significantly greater in the treatment group (p = 0,04). 77,8% of the treated eyes demonstrated at least some resorption of Drusen. Drusen that did not respond, showed either massive confluence or pronounced flattening. None of the treated eyes developed either choroidal neovascularization (CNV) or atrophy. On the contrary, one eye (11,1%) in the control group developed CNV. The results of this pilot trial suggest the beneficial effect and a long-term safety of the focal laser treatment of bilateral drusen in age-related macular degeneration.

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Histopathology and Ultrastructure of the Argon Laser Lesion in Human Retinal and Choroidal Vasculatures

Cited by 90 publications

References 6 publications

A Comparative study of retinal effects from continuous wave and femtosecond mode‐locked lasers

A Comparative study of retinal effects from continuous wave and femtosecond mode‐locked lasers

Histopathology of Focally Photocoagulated Preretinal New Vessels

Langzeiteffekt und Sicherheit der fokalen Laserkoagulation bilateraler Drusen bei altersbedingter Makuladegeneration

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