Histopathological substrate of the atrial myocardium in the progression of obstructive sleep apnoea–related atrial fibrillation

Zhang, Ling; Ye, Kun; Xiaokereti, Jiasuoer; Ma, Mei; Guo, Yuanyuan; Zhou, Xianhui; Tang, Baopeng

doi:10.1007/s11325-020-02128-8

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…To explore the pathogenesis of OSA patients, OSA animal models were established in different species, including dogs, rats and lambs. [21][22][23] OSA patients were characterised by inharmonious craniofacial structures, such as retrusive mandible and vertically overdeveloped mandible, which may cause a structural alteration of the UA and lead to different levels of obstruction. 24 Compared to previous OSA models, we found that rabbits were obligate nose breathers due to their epiglottis positioned rostrally to the soft palate.…”

Section: Discussionmentioning

confidence: 99%

Role of NF‐κB in cardiac changes of obstructive sleep apnoea rabbits treated by mandibular advancement device

Kang,

Zhu,

Zhang

et al. 2024

J of Oral Rehabilitation

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BackgroundObstructive sleep apnoea (OSA) is an independent risk factor for cardiovascular diseases. We aimed to investigate the role of nuclear factor‐kappa B (NF‐κB) in the changes of cardiac structures in OSA rabbits treated by mandibular advancement device (MAD).MethodsEighteen male New Zealand white rabbits aged 6 months were randomly divided into three groups: control group, group OSA and group MAD. Hyaluronate gel was injected into the soft palate of the rabbits in group OSA and group MAD to induce OSA. The cone beam computer tomography (CBCT) of the upper airway and polysomnography (PSG) was performed to ensure successful modelling. CBCT and PSG were applied again to detect the effects of MAD treatment. All animals were induced to sleep in a supine position for 4–6 h a day for 8 weeks. Then the levels of NF‐κB, Interleukin 6 (IL‐6), Interleukin 10 (IL‐10) and the proportion of myocardial fibrosis (MF) were detected.ResultsThe higher activation of NF‐κB, IL‐6 and IL‐10 were found in the OSA group than in the control group, leading to the increase of collagen fibres compared with the control group. Furthermore, the apnoea‐hypopnea index (AHI) was positively correlated with the above factors. There were no significant differences between group MAD and the control group.ConclusionThe NF‐κB pathway was activated in the myocardium of OSA rabbits, which accelerated the development of MF. Early application of MAD could reduce the activation of NF‐κB in the myocardium and prevent the development of MF.

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Section: Discussionmentioning

confidence: 99%

Role of NF‐κB in cardiac changes of obstructive sleep apnoea rabbits treated by mandibular advancement device

Kang,

Zhu,

Zhang

et al. 2024

J of Oral Rehabilitation

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“…Correspondingly, alterations in this dynamic balance play a crucial role in the progression of diverse diseases. Recent studies have shown that mitochondrial abnormalities may be one of the pathological mechanisms of the obstructive sleep apnea-related cardiac injury (Han et al, 2018;Zhang et al, 2021), while maintaining the integrity of mitochondria allows the survival of cardiomyocytes under hypoxic conditions (Pang et al, 2021). Moreover, the disorder in mitochondrial dynamic balance serves as an underlying mechanism in hypoxia-induced kidney damages, which may provide a novel therapeutic target for diabetic nephropathy (Jiang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Dynamics, Mitophagy, and Mitochondria–Endoplasmic Reticulum Contact Sites Crosstalk Under Hypoxia

Wang

Tan

Miao

et al. 2022

Front. Cell Dev. Biol.

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Mitochondria are double membrane organelles within eukaryotic cells, which act as cellular power houses, depending on the continuous availability of oxygen. Nevertheless, under hypoxia, metabolic disorders disturb the steady-state of mitochondrial network, which leads to dysfunction of mitochondria, producing a large amount of reactive oxygen species that cause further damage to cells. Compelling evidence suggests that the dysfunction of mitochondria under hypoxia is linked to a wide spectrum of human diseases, including obstructive sleep apnea, diabetes, cancer and cardiovascular disorders. The functional dichotomy of mitochondria instructs the necessity of a quality-control mechanism to ensure a requisite number of functional mitochondria that are present to fit cell needs. Mitochondrial dynamics plays a central role in monitoring the condition of mitochondrial quality. The fission–fusion cycle is regulated to attain a dynamic equilibrium under normal conditions, however, it is disrupted under hypoxia, resulting in mitochondrial fission and selective removal of impaired mitochondria by mitophagy. Current researches suggest that the molecular machinery underlying these well-orchestrated processes are coordinated at mitochondria–endoplasmic reticulum contact sites. Here, we establish a holistic understanding of how mitochondrial dynamics and mitophagy are regulated at mitochondria–endoplasmic reticulum contact sites under hypoxia.

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Renal denervation alleviates chronic obstructive sleep apnea-induced atrial fibrillation via inhibition of atrial fibrosis and sympathetic hyperactivity

et al. 2023

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Histopathological substrate of the atrial myocardium in the progression of obstructive sleep apnoea–related atrial fibrillation

Cited by 6 publications

References 41 publications

Role of NF‐κB in cardiac changes of obstructive sleep apnoea rabbits treated by mandibular advancement device

Role of NF‐κB in cardiac changes of obstructive sleep apnoea rabbits treated by mandibular advancement device

Mitochondrial Dynamics, Mitophagy, and Mitochondria–Endoplasmic Reticulum Contact Sites Crosstalk Under Hypoxia

Renal denervation alleviates chronic obstructive sleep apnea-induced atrial fibrillation via inhibition of atrial fibrosis and sympathetic hyperactivity

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