Histopathological study of Salivary gland lesions

Abstract

Introduction: There is a wide spectrum of salivary gland lesions with morphologically and clinically diversity which is a difficult task for histopathological interpretation. There are three major salivary glands-parotid, submandibular, and sublingual as well as minor salivary glands distributed throughout the mucosa of the oral cavity. Neoplastic and non-neoplastic disease may develop within any of these. Aims: (1) To study the histopathological features of salivary gland lesions, (2) To study the prevalence of salivary gland lesions in tertiary care hospital, (3) To evaluate the incidence, age at the occurrence, and sex ratio among the patients with salivary gland lesions, (4) To compare the result of our study with other studies. Material and Method: Retrospective study was done from January 2016 to June 2018. The study was done on 55 specimens from patients with salivary gland lesions which are referred to the Department of Pathology from Department of ENT and Surgery, P.D.U. Medical college, Rajkot. Salivary gland specimens were immediately fixed in 10% formalin and processed by paraffin embedding. Sections were stained by hematoxylin and eosin stain. Finally, microscopic examination was done to diagnose Result: In present study, out of 55 cases, 05 cases (9.1%) were inflammatory, 41 cases (74.5%) were benign and 09 cases (16.4%) were malignant. Most common benign tumor of salivary gland was pleomorphic adenoma followed by Warthin's tumor. Most common malignant tumor of salivary gland was mucoepidermoid carcinoma. Conclusion: Histopathological study of salivary gland lesions is the most important method in establishing the final diagnosis and subtyping. Salivary gland tumors are relatively less common and they exhibit a wide variety of microscopic appearances even within one particular lesions.

Frequency and pattern of salivary gland lesions at a tertiary care centre

“…Out of 50 Muco-epidermoid carcinoma , present study reported (33 cases, 66%) of low grade Muco-epidermoid carcinoma which is consistent with a recent study in USA by Shafique et al 23 classified majority of mucoepidermoid carcinoma as low grade(44 cases, 64%) out of 69 cases. Acinic cell carcinoma presented as the third most common malignancy in present study, a finding similar to Chavda et al 24 and Huang et al 25 . However, Arrangoiz et al 26 mentioned acinic cell carcinoma as the second most common malignancy in parotid gland.…”