Histopathological spectrum of tumor and tumor like lesions of oral cavity and oropharynx in tertiary care hospital

Abstract

Background: Oropharyngeal cancers are most commonly observed cancers in Indian population. Oropharyngeal cancers have a poor prognosis. A histopathological study of lesions will give the exact cause and helps in initiation of optimal therapy at the earliest. Settings and design: Prospective study Aims: To study the histopathological changes in tumour and tumour like lesions of oral cavity and oropharynx Material and Methods: A prospective study was carried out in patients of oral cavity and oropharynx lesions. Total 100 biopsies and resected specimens were studied. Data included sociodemographic data, clinical features and histopathological diagnosis of the specimen. Statistical analysis used: Appropriate statistical tests Results and Conclusion: In our study we observed 10% tumor like lesions, 4% benign lesions, 4% premalignant lesions and 63% malignant lesions. Mucocele was the commonest tumor like lesion. Squamous cell carcinoma was the most common malignant lesion in our study seen in 95.2% cases. Out of 60 Squamous cell carcinoma cases, 11.6% had lymph node metastases and 3.3% showed lymphovascular invasion. In TNM staging of 14 cases who underwent resection with modified radical neck dissection, maximum number of cases belonged to Stage II (35.71%) and Stage IV (35.71%).

The Histopathological Study of Tumor and Tumor-Like Lesions of Oral Cavity and Oropharynx

“…Glandular carcinoma was found in 4% of them. Shruthi et al [12] from Karnataka out of 63 cases of malignant lesions in our study, squamous cell carcinoma was the most common histological type accounting for 60 cases (95.2%). All the studies are comparable with my studies.…”

“…Pan chewing habit was found in 59% of men and 90% of women. In a study by Shruthi et al [12] from Karnataka among malignant lesions in our study, 60.3% had a history of tobacco consumption, 17.5% consumed both alcohol and tobacco, 9.5% were alcoholics, and 12.7% patients did not have any habits. All the studies are comparable with my studies as they show a maximum number of patients addicted to tobacco.…”

“…Iype et al [6] found well-differentiated squamous cell carcinoma in 52.6% of cases, moderately differentiated in 34.2%, and poorly differentiated in 8.9% of cases. Shruthi et al [12] from Karnataka out of 60 cases of squamous cell carcinoma, the majority were well-differentiated type seen in 31 cases (51.67%) followed by moderately differentiated in 23 cases (38.33%) and 6 cases (10%) were poorly differentiated. Ahmed and Islam [16] from Dhaka, Bangladesh also reported welldifferentiated squamous cell carcinoma were the most common oral cavity malignancy.…”

“…Mehrotra et al [5] from Allahabad, India reported a Male: Female ratio of 3.27:1. In a study by Shruthi et al [12] from Karnataka, male preponderance was seen in malignant lesions with a male-to-female ratio of 1.7:1. All the studies are comparable with my studies.…”