Histopathological spectrum of childhood nephrotic syndrome in Pakistan

Abstract

MCD and its variants are the leading cause of overall INS in children, followed by FSGS, which is the predominant pathology in steroid-resistant and adolescent nephrotic syndrome (NS). Our data are in accordance with recent series from around the world with similar biopsy indications. The study defines the true pattern of glomerulopathies in childhood INS for the first time in Pakistan.

Association of the ACE-II genotype with the risk of nephrotic syndrome in Pakistani children

“…The MCD and FSGS are common histological variants of NS found in our population (Mubarak et al, 2009). As also reported by others, the I/D polymorphism showed no association with FSGS and MCD in our NS population (Saber-Ayad et al, 2010;Serdaroglu et al, 2005).…”

R: Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study

“…The authors have also analyzed certain glomerular and tubulointerstitial changes on renal biopsies, which might have influenced the response to steroids in these children. ISRNS accounts for 10-30% of nephrotic syndrome (NS) in children around the world (2,3). It poses significant diagnostic and therapeutic challenges to both the nephrologists and the nephropathologists.…”

Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications

“…It is widely accepted that NS in children does not require any histological evaluation as first-line approach [55,62] . Indeed, in this population about 90% of idiopathic NS are related to minimal glomerular lesions with very high response-rate to corticosteroid treatment and a very low risk of progression to ESKD [63,64] . In a study of 30 children, the response to cyclophosphamide therapy correlated better with the initial corticosteroid response than to renal histopathology [65] .…”