Association of the ACE-II genotype with the risk of nephrotic syndrome in Pakistani children

Shahid, Saba; Abid, Aiysha; Mehdi, Q; Firasat, Sadaf; Lanewala, Ali; Naqvi, Ali Anwar Syed; Rizvi, A; Khaliq, Shagufta

doi:10.1016/j.gene.2011.10.016

Cited by 5 publications

(2 citation statements)

References 18 publications

(17 reference statements)

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“…In the present study, we observed that ACE (I/D) allelic distribution was not elevated in the control group when compared to the different subsets of nephrotic (SSNS/SRNS) cases, which is in agreement with previous studies from different ethnic populations such as Swedish and Egyptian [22 , 25 – 27] . On the contrary, the ACE -II genotype was found more frequent in SSNS in North Indian and Pakistani children [17 , 28] . However, DD genotype was higher in north Indian population [15] which also coincided with the Egyptein [25] , Turkish [29] and Taiwanese [19] nephrotic children.…”

Section: Discussionmentioning

confidence: 99%

Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome

et al. 2019

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Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%–15% of nephrotic syndrome cases are non-responders of steroid treatment (SRNS). Angiotensin converting enzyme (ACE) (I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE (I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome (162 boys and 98 girls) and 218 (140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE (I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases (minimal change disease, n=51; focal segmental glomerulosclerosis, n=27; diffuse mesangial proliferation, n=8). We segregated them into the minimal change disease / focal segmental glomerulosclerosis groups and observed that the ACE ‘D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ‘I’ allele was assessed as having very weak association in cases of minimal change disease. ‘II’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of ‘ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE (I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome

et al. 2019

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“…Cerebrovascular endothelium was reported to be rich in ACE ( Ehlers and Riordan, 1989 , McGeer and Singh, 1992 ). The ACE (I/D) gene polymorphism was shown to be associated in several diseases including diabetes mellitus ( Inanir et al, 2013 ), nephrotic syndrome ( Shahid et al, 2012 ), Alzheimer's disease ( Narain et al, 2000 ), hypertension, and coronary artery disease ( Dhar et al, 2012 , Zhou et al, 2013 ). In the present study, we carried out a retrospective analysis of ACE (I/D) genotype and allele polymorphism among IS patients from south India.…”

Section: Introductionmentioning

confidence: 99%

ACE-II genotype and I allele predicts ischemic stroke among males in south India

et al. 2014

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Two hundred ischemic stroke patients and 193 age and sex matched healthy controls were studied for the presence of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) gene polymorphism. The PCR studies revealed that ACE ‘II’ (OR = 2.055; p = 0.004) genotype and ‘I’ (OR = 1.411; p = 0.018) alleles were significantly associated with IS patients. Gender specific analysis revealed a strong association of ‘II’ (OR = 2.044; p = 0.014) genotype and ‘I’ (OR = 1.531; p = 0.011) allele with male sex. Classification of patients based on TOAST criteria, revealed a significant association for ‘II’ genotype (OR = 1.713; p = 0.043) and ‘I’ (OR = 1.382; p = 0.039) allele in LVD patients only. When the data was stratified based on age and sex, a statistically significant association was observed for ACE ‘II’ genotype (OR = 2.288; p = 0.006) and ‘I’ allele (OR = 1.395; p = 0.054) in IS male patients of > 50 years of age. The ACE ‘D’ allele was found to be increased in controls (OR = 0.709; p = 0.018) than IS patients. Multivariate logistic regression analysis showed that smoking and diabetes were the most powerful independent risk factor in LVD type of stroke. Thus, we presented here an evidence for a strong association of ACE ‘II’ genotype and ‘I’ allele compounded by factors such as smoking and diabetes among south Indian IS patients.

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The prevalence of pharmacogenetic variants of vitamin K epoxide reductase complex subunit 1 gene (rs9923231), cytochrome P450 family 2 subfamily C member 9 gene (rs1799853) and cytochrome P450 family 3 subfamily-A member-5 gene (rs776746) among 13 ethnic groups of Pakistan

et al. 2023

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Association of the ACE-II genotype with the risk of nephrotic syndrome in Pakistani children

Cited by 5 publications

References 18 publications

Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome

Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome

ACE-II genotype and I allele predicts ischemic stroke among males in south India

The prevalence of pharmacogenetic variants of vitamin K epoxide reductase complex subunit 1 gene (rs9923231), cytochrome P450 family 2 subfamily C member 9 gene (rs1799853) and cytochrome P450 family 3 subfamily-A member-5 gene (rs776746) among 13 ethnic groups of Pakistan

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