Histopathological, Serological, and Molecular Confirmation of Indigenous Alveolar Echinococcosis Cases in Mongolia

Itō, Akira; Agvaandaram, Gurbadam; Bat-Ochir, Oyun-Erdene; Chuluunbaatar, Batsaikhan; Gonchigsenghe, Nyamkhuu; Yanagida, Tetsuya; Sako, Yasuhito; Narankhajid, Myadagsuren; Dorjsuren, Temuulen; Nakaya, Kazuhiro; Nakao, Minoru; Ishikawa, Yuji; Davaajav, Abmed; Dulmaa, Nyamkhuu

doi:10.4269/ajtmh.2010.09-0520

Cited by 43 publications

(50 citation statements)

References 15 publications

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“…In the past three decades, Echinococcus multilocularis , the causative agent of human alveolar echinococcosis (AE), has been newly reported in countries of Europe (Davidson et al 2012) and discovered in foci of relatively high incidence in China and neighbouring countries of Central Asia and Siberia (Craig et al 1992; Ito et al 2003, 2010; Li et al 2005; Yang et al 2006; Torgerson et al 2009; Ziadinov et al 2011; Konyaev et al 2012). Although the distribution range of the parasite is described as being widespread in the northern hemisphere, large regional gaps and differences are observed.…”

Section: Introductionmentioning

confidence: 99%

Transmission ecosystems ofEchinococcus multilocularisin China and Central Asia

et al. 2013

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SUMMARYFrom continental to regional scales, the zoonosis alveolar echinococcosis (AE) (caused by Echinococcus multilocularis) forms discrete patches of endemicity within which transmission hotspots of much larger prevalence may occur. Since the late 80s, a number of hotspots have been identified in continental Asia, mostly in China, wherein the ecology of intermediate host communities has been described. This is the case in south Gansu, at the eastern border of the Tibetan plateau, in south Ningxia, in the western Tian Shan of Xinjiang, and in the Alay valley of south Kyrgyzstan. Here we present a comparative natural history and characteristics of transmission ecosystems or ecoscapes. On this basis, regional types of transmission and their ecological characteristics have been proposed in a general framework. Combining climatic, land cover and intermediate host species distribution data, we identified and mapped 4 spatially distinct types of transmission ecosystems typified by the presence of one of the following small mammal ‘flagship’ species: Ellobius tancrei, Ochotona curzoniae, Lasiopodomys brandtii or Eospalax fontanierii. Each transmission ecosystem had its own characteristics which can serve as a reference for further in-depth research in the transmission ecology of E. multilocularis. This approach may be used at fine spatial scales to characterize other poorly known transmission systems of the large Eurasian endemic zone, and help in consideration of surveillance systems and interventions.

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Section: Introductionmentioning

confidence: 99%

Transmission ecosystems ofEchinococcus multilocularisin China and Central Asia

et al. 2013

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“…So far five cases of AE have been documented in four provinces, mainly in the northwest of Mongolia (Ito and Budke, 2015). Molecular studies from metacestodes of three AE patients revealed both Asian and the Mongolian E. multilocularis haplotypes (Ito et al, 2010). p0540…”

Section: 2 Infections In Animalsmentioning

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Global Distribution of Alveolar and Cystic Echinococcosis

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et al. 2017

Advances in Parasitology

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“…Thus, we were able to identify E. vogeli in this sample. This underlines the difficulty of DNA extraction from FFPE (degradation of DNA and low yield of extraction of long DNA fragments) and the need for shorter PCR targets for identification of infectious agents using PCR and sequencing in FFPE tissue (16)(17)(18)). An alternative quantitative PCR (qPCR) approach that targets short mitochondrial DNA fragments could also be of interest on FFPE DNA extract, either by combining species-specific targets or by defining genus-specific system, followed by melting curve analysis for species diagnosis (19,20).…”

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