Histopathological profile of breast cancer in an African population

Abstract

Background:Currently breast cancer (BRCA) still remain the most commonly diagnosed female cancer globally with a significant geographic, racial and ethnical variations in its incidence.Aim:This article examines the frequency and histological types and grades of BRCA in a pioneer teaching Hospital in Delta State, Nigeria.Materials and Methods:H and E stained-slides of breast biopsies diagnosed at the Central Hospital, Warri from 2005 to 2011 were archived and studied. Request forms were scrutinized for clinical bio-data, diagnosis and histological sections were analyzed. Data obtained were analyzed using the Statistical Package for the Social Sciences version 17 statistical package (SPSS) Incorporated, Chicago, Illinois, USA, and value presented descriptively.Results:During this period, 905 breast lesions were seen. Out of this, 261 were BRCAs, of which 260 cases were females and one case was a male. The peak age incidence for BRCA and its variants was 40-49 years accounting for (n = 94/261; 36%). The mean age of BRCA was 46 years (6.2). Invasive carcinoma of no special type (NST) was the most commonly encountered histological group of breast carcinoma constituting (n = 203/261, 77.7%) with the high grade invasive ductal carcinoma as the leading diagnosis.Conclusion:Majority of BRCAs encounter was invasive ductal carcinoma of NST with bulk of patients presenting in Stages III and IV.

Breast diseases histologically diagnosed at a tertiary facility in Uganda (2005–2014)

“…This is consistent with findings in Africa, Europe and the world at large for the most frequently diagnosed breast cancer type [14, 15]. The fact that a considerable amount of records we retrieved were diagnosed or concluded only as either “adenocarcinoma” or “breast malignancy”, may explain why we observed less IDC compared to the documented 70–88% elsewhere [16–18]. More ancillary diagnostic techniques or better tissue harvest may be necessitated to counter this.…”

Epidemiology of Female Breast Cancer in Ogun State: Intra- and Inter-regional Discuss

“…At the national level, only the South-West, South-South and North-Central Nigeria had cases of Paget's disease. Its prevalence in Ogun State (South-West) was higher than that recorded in Delta State (South-South) [13] but lower than that reported in Benue State, North-Central [15]. The prevalence of medullary carcinoma in this study was higher than that reported in Maiduguri [18] and Warri [13] but lower than that reported in Lagos [10], Benin [14] and Zaria [20].…”

“…This suggests that individuals in Ogun State are at low risk of developing medullary carcinoma than its neighbouring South-West State (Lagos State).. Mucinous Carcinoma is a mucin containing breast cancer surrounded by tumor cells [36]. Our study showed low prevalence of mucinous carcinoma in Ogun State compared with that found in other States in Nigeria [10,11,[13][14][15]18,20].…”

“…Its prevalence in Ogun State (South-West) was higher than that recorded in Delta State (South-South) [13] but lower than that reported in Benue State, North-Central [15]. The prevalence of medullary carcinoma in this study was higher than that reported in Maiduguri [18] and Warri [13] but lower than that reported in Lagos [10], Benin [14] and Zaria [20]. This suggests that individuals in Ogun State are at low risk of developing medullary carcinoma than its neighbouring South-West State (Lagos State).. Mucinous Carcinoma is a mucin containing breast cancer surrounded by tumor cells [36].…”

“…This is in contrast to the findings of Abdulrahman et al [27] who reported highest breast cancer presentations (two-third) among premenopausal women in Africa and among postmenopausal women in Europe. More so, the mean age of breast cancer presentations in Ogun State (50.3%) was higher than that recorded in any Nigerian States [11][12][13][14][15][16][17][18][19][20] and Africa [28].…”