Randomized Clinical Trials on Breast Cancer in Nigeria and Other Developing Countries: Challenges and Constraints

Erhabor, O; Udomah, F; Ahmed, Y; Zama, Isaac; Momodu, Imoru; Adias, Teddy Charles; Erhabor, Tosan; Lori, J; Dangana, Amos; Egenti, Bibiana Nonye; Fredrick, Christy Chinyere; Okara, Godswill Chikwendu; Iwueke, Ikechukwu; Ajayi, OI; Abiodun, Emokpae

doi:10.1007/978-3-319-57943-6_6

Cited by 3 publications

(5 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the output from the United States and the United Kingdom was well over 1,000 articles each in 2018. Erhabor et al 24 stated that barriers such as loss to follow up, poor health infrastructure, inadequate data management, and cost-related challenges might limit the capacity to conduct RCTs in Nigeria. A report by the Global Forum for Health Research stated the importance of improving research capacity to improve the quality of health care delivered in developing countries.…”

Section: Discussionmentioning

confidence: 99%

“…In many African countries, funding for clinical research is mostly obtained from collaborations with partners in Western countries and local pharmaceutical companies. 24 There were concerns that this could reduce the capacity of African scientists to conduct sustainable research relevant to their various countries. 26 …”

Section: Discussionmentioning

confidence: 99%

“…30 , 31 In Nigeria, there is little government funding for cancer research, as limited resources are predominantly allocated toward program implementation. 24 However, this only increases the need for a reliable evidence base, to evaluate program outcomes and to ensure that resources are used efficiently. 32 Since 2011, the main government funding channel for research has been the Tertiary Education Trust Fund.…”

Section: Discussionmentioning

confidence: 99%

“…Such studies will provide data that are socioculturally appropriate and economically feasible for Nigeria, leading to evidence-based treatment guidelines, which will improve the quality of breast cancer care in Nigeria. 24 It is essential for the Nigerian government to increase funding for cancer-related research and formulate policies that aim to encourage the practice of EBM. Increased funding from philanthropic donors and corporate organizations will help to build sustainable breast cancer research infrastructure in Nigeria.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Breast Cancer Research to Support Evidence-Based Medicine in Nigeria: A Review of the Literature

Fatiregun

Oluokun

Lasebikan

et al. 2021

JCO Global Oncology

View full text Add to dashboard Cite

PURPOSE Breast cancer is the most common malignancy in women worldwide. In Nigeria, it accounts for 22.7% of all new cancer cases among women. Evidence-based medicine (EBM) entails using the results from healthcare research to enhance the clinical decision-making process and develop evidence-based treatment guidelines. Level 1 and 2 studies, such as randomized controlled trials, meta-analyses, and systematic reviews of randomized controlled trials, yield more robust types of evidence. This study reviewed the levels of evidence of breast cancer publications in Nigeria. METHODS We conducted an electronic literature search of all studies published on breast cancer in Nigeria from January 1961 to August 2019. We reviewed all the articles found under the search term “Breast Cancer in Nigeria” on medical databases. RESULTS Our search identified 2,242 publications. One thousand two hundred fifty duplicates were removed, and 520 were excluded. A total of 472 articles were considered eligible for this review. Most of these articles were case series or reports (30.7%), qualitative studies (15.7%), followed by cross-sectional studies (13.3%), laboratory studies (12.9%), case-control studies (6.1%), case reports (7%), and cohort (5.7%). CONCLUSION Breast cancer research in Nigeria is yet to produce much evidence of the types considered to best support EBM. The scarcity of data hampers the implementation of EBM in Nigeria. Currently, most treatment guidelines are adapted from those developed in other countries, despite genetic differences among populations and different environmental influencing factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Breast Cancer Research to Support Evidence-Based Medicine in Nigeria: A Review of the Literature

Fatiregun

Oluokun

Lasebikan

et al. 2021

JCO Global Oncology

View full text Add to dashboard Cite

show abstract

“…The World Health Organization in 2020 recorded a mortality rate of about 10 million globally relating to cancer, and cases of approximately 70% occurred in low and middle-income countries [2]. In Nigeria, about 102,000 thousand new cases of different cancer occur annually, with high number of recorded cases of breast cancer [3], [4]. Breast cancer results from abnormal changes in the genes responsible for regulating cell growth in the breast tissues.…”

Section: Introductionmentioning

confidence: 99%

Pectoral Muscle Removal in Digital Mammograms Using Region Based Standard Otsu Technique

Anusionwu,

Chijindu,

Eneh

et al. 2023

IJEEI

View full text Add to dashboard Cite

Mammography is usually the first preference of imaging diagnostic modalities used for breast cancer detection in the early stage. Two projections Cranio Caudal (CC) and Medio-Lateral Oblique (MLO), used during digital mammogram acquisition depict different degrees for visualizing breast tissues; the MLO view shows more breast tissue and Pectoral Muscle (PM) area when compared to the CC view. Although the PM is a criterion used for proper positioning, it can result in biased results of mammographic analysis like cancer detection and breast tissue density estimation because the PM area has a similar or even higher intensity than breast tissue and breast lesions if present. This paper proposed a Region Based Standard Otsu thresholding method for the elimination of PM area present in MLO mammograms. The developed algorithm was implemented using 322 digital mammograms from the Mammographic Image Analysis Society (MIAS) database, and the difference between the PM detected and the manually drawn PM region by an expert was evaluated. The results showed an average: Jaccard Similarity Index, False Positive Rate (FPR) and False Negative Rate (FNR) of 93.2%, 3.54%, and 5.68% respectively, and also an acceptable rate of 95.65%.

show abstract

Environments and diseases: A voice from developing countries

Rajah

Ding

2017

Environ Dis

View full text Add to dashboard Cite

Randomized Clinical Trials on Breast Cancer in Nigeria and Other Developing Countries: Challenges and Constraints

Cited by 3 publications

References 106 publications

Breast Cancer Research to Support Evidence-Based Medicine in Nigeria: A Review of the Literature

Breast Cancer Research to Support Evidence-Based Medicine in Nigeria: A Review of the Literature

Pectoral Muscle Removal in Digital Mammograms Using Region Based Standard Otsu Technique

Environments and diseases: A voice from developing countries

Contact Info

Product

Resources

About