Histopathological pattern of renal tumours seen in Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria

Rt, Isah; Sm, Sahabi; Sn, Adamu; At, Muhammad; Mungadi, Ismaila Arzika

doi:10.5897/ajcpath13.004

Cited by 8 publications

(21 citation statements)

References 10 publications

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“…Excluding the outlier patient aged 8 years, the mean age from this study is 40 ± 13 years. This is within range of the national average of 45± 4 years (peak age in fifth decade) (2,(4)(5)(6)(7)(12)(13)(14)(15)(16)(17)(18)(19). This is about two decades earlier than the pattern described for western countries where the peak age incidence is in the seventh decade (11,20,21).…”

Section: Discussionsupporting

confidence: 64%

“…Frank et al (29) in their study have also observed that only 1% of all tumors less than 1 cm and 9.2% of all tumors less than 2 cm are usually high grade malignancies. The occurrence of CC carcinoma in patients in our setting (47.8%), even though the most common subtype, is lower than the range of between 60%-85.7% (12)(13)(14)(15)(16)(17)(18) documented in other centers in the country and worldwide (30)(31)(32). In contrast, even though there was a high frequency of PC (30.4%), it was within the range of between 23.8% and 46.2% locally reported by others (5,12,17).…”

Section: Discussioncontrasting

confidence: 56%

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Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria

Akinfenwa¹,

Jareenat²,

Noah³

2018

Immunopathol Persa

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Introduction:Histologically, renal cell carcinoma (RCC) is classified into predominantly clear cell carcinoma, papillary carcinoma (PC), chromophobe carcinoma, collecting ducts of Bellini carcinoma and Xp11 carcinoma. Objectives: This study aims to evaluate histological profile and staining patterns of RCC subtypes. Materials and Method: All cases of RCC histologically diagnosed in the pathology department of a teaching hospital in northern Nigeria in 2015 were stained using a panel of 34ẞE12, CK7, RCC-ma and CD10 antibodies. Results: Around 23 cases of RCC, at stage III, were diagnosed. Male: Female ratio was 1:1.9 with a mean age of 40±13 years. The tumors comprised of 11 (47.8%), cases of clear cell (CC) carcinoma, 7 (30.4%) cases of PC, 4 (17.4%) cases of chromophobe carcinoma and a case (4.4%) of Xp11.2associated carcinoma. Eighty-eight percent of the CC carcinomas were RCC-ma+, 63% were CD10+ while 50% were CK7+. Seventy-five percent of the PCs were RCC-ma+ and 50% were CD10+. The chromophobe (CP) and the Xp11.2-associated carcinomas were only positive for RCC-ma and CD10. All cases of PCs, chromophobe and Xp11.2 related carcinomas were negative for CK7, and all were 34ẞE12 negative. Conclusion: In contrast to populations with high incidence of RCC, our patients are predominantly female, younger, presented at higher stages and mostly presented with CC carcinoma. AbstractCitation: Akinfenwa AT, Jareenat AO, Noah DT. Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria. Immunopathol

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Section: Discussionsupporting

confidence: 64%

Section: Discussioncontrasting

confidence: 56%

Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria

Akinfenwa¹,

Jareenat²,

Noah³

2018

Immunopathol Persa

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“…15 The most common histopathological type of renal tumour in the present study was clear cell carcinoma, comprising 31 cases (60.7%). Isah et al 16 (61.5%) and Sascha et al 17 (77.9%) also showed the predominant cell type to be clear cell carcinoma. The second commonest one was papillary carcinoma followed by chromophobe carcinoma, just as the pattern in previous studies.…”

Section: Histopathological Analysismentioning

confidence: 93%

“…These findings also tally with the ones in the literature. 16,17 Microvascular Invasion Microvascular invasion is an important prognosticator in high risk cases for the development of metastatic disease when demonstrated. Capsular invasion may serve as an additional factor in high-risk stratification of patients with localised RCC.…”

Section: Histopathological Analysismentioning

confidence: 99%

Histopathological Analysis of Renal Tumours- A Two Year Study From a Tertiary Care Centre

Chathukutty¹,

Pothen²,

Kandasamy³

et al. 2017

jemds

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BACKGROUNDThere is an increased incidence of renal tumours every year in the last three decades, RCC being the most common. There is little published data on the spectrum of renal tumours in India, especially Southern parts like Kerala. Hence, this study is undertaken to analyse the relative frequencies of different types of renal tumours and their histopathological characteristics.The aim of the study is to find out the mean age of presentation, mode of presentation and gender predominance of renal tumours, the histopathological subtype of renal tumours and microvascular invasion. MATERIALS AND METHODSThis was a descriptive study carried out in the Department of Pathology, Government Medical College, Kottayam. 51 nephrectomy specimens of renal neoplasm received during the period of two years were studied. Statistical analysis was done using SPSS version 16. RESULTSAmong 51 nephrectomy specimens of renal neoplasm, 90.2% (46/51 cases) were of malignant tumours. Of 46 malignant cases 31/51 cases were of clear cell carcinoma, 7/51 cases were of papillary carcinoma, 5/51 cases were of chromophobe carcinoma, 1/51 were of multilocular cystic RCC and 2/51 were of unclassified RCC. Of 5 benign cases (9.8%) 2/51 were of oncocytoma, 1/51 were of solitary fibrous tumour, 1/51 were of clear cell sarcoma and 1/51 were of angiomyolipoma. Majority of renal neoplasms (90.2%) were RCC, seen predominantly in middle aged males (mean age is 52.41 years). They mostly presented with symptoms of abdominal pain (37.2%) and mass (31.3%). The classical symptom triad (macroscopic haematuria, palpable tumour and pain) was less commonly seen (8.7%). Clear cell carcinoma was the most common histological type of renal tumours (60.7%) and also had the most number of capsular (60%) and renal sinus invasion (72%), which may indicate bad prognosis. As the size, stage/ grade of the tumour increased, the symptoms did not increase. Therefore, relative paucity of symptoms does not mean that the tumour has not made much progression/ is completely curable/ resectable. CONCLUSIONIncidental tumours being in the lower stages and lower nuclear grades indicate that early detection of renal neoplasms by radiological screening may have some value. However, large scale case control studies are needed to make accurate analysis of renal neoplasms including the measurement of cancer specific survival and prognosis. The incidence rates of RCC have risen steadily each year during the last three decades in most parts of the world with an average increase of 2% to 3% per year. 1 The increased incidence is primarily due to two reasons. One is the increased detection via radiological methods like USG and CT. 'Financial or Other Competing Interest': None. Submission 24-10-2017, Peer Review 21-11-2017, Acceptance 27-11-2017, Published 11-12-2017. Corresponding Author: Dr. Lillykutty Pothen, Kaniankunnel House, Gandhinagar P. O, Kottayam. E-mail: glamskan@gmail.com DOI: 10.14260/jemds/2017/1453 Another reason is the increased prevalence of risk factors l...

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“…NBT is the most common malignant tumor of the kidney in children, and it is the commonest childhood tumor [9] in some centers in Africa. Histologically, renal cell carcinoma occurs in three most common forms, namely: clear cell carcinomas, papillary renal cell carcinomas, and chromophobe renal cell carcinomas [12]. From the ongoing, however, the present study aims to determine the occurrence and histopathology patterns of malignant renal tumors including the histologic subtypes in a single multi-national study center, in Benin City, Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Renal Biopsies in A Tertiary Health Institution in South-Southern, Nigeria: A Single Multi-National Center Study.

Odigie¹,

Atoigwe²

2016

IOSR

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Malignant renal tumour is a relatively rare type of cancer that occurs third in urological tumours after prostate and bladder cancers. It is among the leading cancers in western societies and is male predominant, aged (16-80) years with a peak incidence in the 5th and 6th spans of life (45-60 years) than in females. There are limited studies in the literature reporting its existence in South-southern, Nigeria. A little knowledge of its existence is known in Benin City, which propelled this study. The aims of this study were to determine the occurrence and histopathology patterns of malignant renal tumours including the histologic subtypes in a multi-national study centre. This is a 25-year retrospective study spanning from 1991 to 2016; in which the report of 19,123 haematoxylin and eosin stained sections were reviewed. Patient's data (age, sex and ethnicity) were also retrieved from the archives of the histopathology laboratory of the University of Benin Teaching Hospital (UBTH), Benin City, Nigeria and were analysed using the Statistical Package for Social Sciences (SPSS) version 20.0. The result revealed that 69 samples were reconfirmed as renal tumours and a preponderance of males (66.7%) was observed. Renal cell carcinoma 35/53(66.0%) has the highest occurrence of malignant renal tumours, and nephroblastoma (20.8%), which is closely followed by transitional cell carcinoma (13.2%). This study, therefore, concludes that malignant renal tumour is male predominant while renal cell carcinoma has the highest occurrence in Benin City, Nigeria. However, a significant finding is the report of papillary renal cell carcinoma and clear cell carcinomas, which appeared to be more common in Nigeria than granular cell carcinomas and clear cell type that are predominant in North America.

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Histopathological pattern of renal tumours seen in Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria

Cited by 8 publications

References 10 publications

Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria

Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria

Histopathological Analysis of Renal Tumours- A Two Year Study From a Tertiary Care Centre

Renal Biopsies in A Tertiary Health Institution in South-Southern, Nigeria: A Single Multi-National Center Study.

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