Histopathological features of sinonasal inverted papillomas in chinese patients

Zhao, Li; Li, Chun Wei; Peng, Jin; Ng, Chew Lip; Lin, Zhi; Li, Ying Ying; Li, Tian Ying; Petersson, Bengt Fredrik; Li, Shi; Wang, De Yun

doi:10.1002/lary.25694

Cited by 23 publications

(52 citation statements)

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“…The pathophysiologic mechanism of this tumor is not fully elucidated but chronic inflammation does appear to play a role. In a recent study by Zhao et al., they found an increased number of inflammatory cells within IPs, specifically macrophages, eosinophils, CD8 T cells, and T‐reg cells. Neutrophils were found to be the most predominant inflammatory cell type in IP .…”

Section: Discussionmentioning

confidence: 94%

“…In a recent study by Zhao et al., they found an increased number of inflammatory cells within IPs, specifically macrophages, eosinophils, CD8 T cells, and T‐reg cells. Neutrophils were found to be the most predominant inflammatory cell type in IP . Furthermore, concomitant inflammatory polyps were found in 28% of the patients in that study .…”

Section: Discussionmentioning

confidence: 94%

“…IP most commonly originates from the lateral nasal wall in the region of the middle meatus where chronic inflammatory changes are most common . Elevated quantities of neutrophils, macrophages, eosinophils, and CD8+ T cells, and T regulatory (T‐reg) cells have been found in IP . Orlandi et al .…”

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confidence: 99%

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Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Papagiannopoulos

Tong

Kuan

et al. 2020

Int Forum Allergy Rhinol

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Background The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors. Methods A retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor. Results Seventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184). Conclusion In this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

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Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Papagiannopoulos

Tong

Kuan

et al. 2020

Int Forum Allergy Rhinol

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“…Genellikle lateral nazal duvardan gelişen bu tümörler paranazal sinüslere, orbitaya hatta intrakraniyal alana ilerleyebilir. [1] Nazal tutulum olmadan paranazal sinüslerde de inverted papillom görü-lebilmektedir. [1,2] Önceden izole nazal septum tutulumu görülen bir olgu bildirilmemiş ise de son yıllarda nazal septum yerleşimli olgular bildirilmiştir.…”

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“…[1] Nazal tutulum olmadan paranazal sinüslerde de inverted papillom görü-lebilmektedir. [1,2] Önceden izole nazal septum tutulumu görülen bir olgu bildirilmemiş ise de son yıllarda nazal septum yerleşimli olgular bildirilmiştir. [3,4] Epitelyal invajinasyonlar skuamöz veya respiratuar epitelden oluşabilir.…”

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A sinonasal inverted papilloma: an evaluation of 38 cases at a single center

Arık¹

2017

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ÖZAmaç: Bu çalışmada, kliniğimizde inverted papillom tanısı konulan hastalar gözden geçirildi ve klinik ve histopatolojik özellikleri sunuldu. Sonuç: Çalışma sonuçlarımız, sinonazal inverted papillomların lokal agresif seyirli, nüks ve malign dönüşüm potansiyelleri olan neoplazmlar olduğunu göstermektedir. Bu nedenle, tedavi radikal cerrahi olmalıdır. Hastalar veAnahtar sözcükler: İnverted papillom; sinonazal papillom; skuamöz hücreli karsinom. ABSTR ACT Objectives:In this study, we review patients with an inverted papilloma who were diagnosed in our clinic and present their clinical and histopathological features. Patients and Methods:A total of 38 patients (31 males, 7 females; mean age 52.2 years; range 16 to 84 years) who were diagnosed with an inverted papilloma in the Department of Pathology of our institution between January 2009 and January 2016 were retrospectively analyzed. Clinical characteristics of the patients, recurrence and malignant transformation rates were evaluated. Results:Of the patients, 17 had right-sided and 18 had leftsided involvement. Three patients had bilateral involvement. A squamous-cell carcinoma developed in four patients. In these patients, the tumor was accompanied by an in situ carcinoma and varying degrees of dysplasia. One patient had severe dysplasia and verrucous hyperplastic changes without an invasive carcinoma. The rate of malignant transformation was found to be 10.5%. Conclusion:Our study results show that sinonasal inverted papillomas are neoplasms with local aggressive course and potential recurrence and malignant transformation. Therefore, treatment should be radical surgery.

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Epithelial Tight Junction Anomalies in Nasal Inverted Papilloma

et al. 2023

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ObjectivesAs a critical component of the epithelial barrier, tight junctions (TJs) are essential in nasal mucosa against pathogen invasion. However, the function of TJs has rarely been reported in nasal inverted papilloma (NIP). This study aims to investigate the potential factors of TJs' abnormality in NIP.MethodsWe assessed the expression of ZO‐1, occludin, claudin‐1, claudin‐3, and claudin‐7 in healthy controls and NIP by real‐time quantitative polymerase chain reaction and immunofluorescent staining. The correlation between TJs expression and neutrophil count, TH1/TH2/TH17 and regulatory T cell biomarkers, and the proportion of nasal epithelial cells was investigated.ResultsUpregulation of ZO‐1, occludin, claudin‐1, and claudin‐7, along with downregulation of claudin‐3, was found in NIP compared to control (all p < 0.05). An abnormal proportion with a lower number of ciliated cells (control vs. NIP: 37.60 vs. 8.67) and goblet cells (12.52 vs. 0.33) together with a higher number of basal cells (45.58 vs. 124.00) in NIP. Meanwhile, claudin‐3 was positively correlated with ciliated and goblet cells (all p < 0.01). Additionally, neutrophils were excessively infiltrated in NIP, negatively correlated with ZO‐1, but positively with claudin‐3 (all p < 0.05). Furthermore, FOXP3, IL‐10, TGF‐β1, IL‐5, IL‐13, and IL‐22 levels were induced in NIP (all p < 0.01). Occludin level was negatively correlated with IL‐10, IL‐5, IL‐13, and IL‐22, whereas ZO‐1 was positively with TGF‐β1 (all p < 0.05).ConclusionNasal epithelial barrier dysfunction with TJs anomalies is commonly associated with abnormal proliferation and differentiation of epithelial cells and imbalance of immune and inflammatory patterns in NIP.Level of EvidenceNA Laryngoscope, 2023

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Histopathological features of sinonasal inverted papillomas in chinese patients

Abstract: NA.

Cited by 23 publications

References 16 publications

Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

A sinonasal inverted papilloma: an evaluation of 38 cases at a single center

Epithelial Tight Junction Anomalies in Nasal Inverted Papilloma

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