Histopathological Evaluation of Neoplastic and Non-Neoplastic Bone Tumours in a Teaching Hospital

Abstract

BACKGROUNDBone tumours are comparatively uncommon among wide array of lesions and pose a diagnostic problem. Definitive clinical diagnosis of bone lesion is often difficult. So it is essential to identify the lesion correctly before deciding the line of treatment. For the correct diagnosis of bone lesions, charting out treatment plan and estimating prognosis, interpretation of biopsy material proves to be indispensable.Aim of the study is to study histopathological features of bone lesions and their correlation with age of presentation, site and type of lesion. MATERIALS AND METHODSThe duration of the study was 2 years [June 2014-May 2016. A review of histopathological reports of all bone specimens received in the Department of Pathology, SVS Medical College over a period of 2 years was done. A total of 46 bone lesions were analysed. Bone biopsy was performed by either percutaneous method with needle/drill or open surgical biopsy. If attached soft tissue was also received, bony tissues were put for decalcification (10% nitric acid). Soft tissue was immediately fixed into 10 % formalin and processed by paraffin embedding. Sections were stained by haematoxylin and eosin stain and microscopic examination was done. RESULTSTotal non-neoplastic bone lesions were 18 (39.1 %) while that of neoplastic lesions were 28 (60.9%). Both neoplastic and nonneoplastic lesions were more prevalent in < 20 years age group. Among the non-neoplastic lesions, osteomyelitis lesions (38.9%) were the commonest while giant cell tumour (42.8%) was common neoplastic lesions. Overall most common bone involved was femur. CONCLUSIONThough bone tumours are less common lesions and pose a diagnostic problem, if viewed in perspective of clinico-radiology and histopathology, a correct diagnosis can be reached.

Bone lesions: Benign, malignant and inflammatory; A Histopathological study

“…In a study conducted by Rhutso Y et al, they showed a male predominance with two age peaks; one at 10 years and the other at 30-40 years [8] . In a study conducted by Reddy et.al, the lesion occurred most commonly in the metaphysis of long bone [11] . The other malignant lesions were Ewing sarcoma, which involved the spinal vertebra followed by plasmacytoma and lymphoma.…”

Study of clinical, radiological, and histopathological features of bone lesions- A two-year study

“…The broad spectrum of bony lesions makes the definitive diagnosis difficult. Clinical presentation can be misleading as in Ewing sarcoma -Fever and raised ESR suggestive of Osteomyelitis [5,6]. The relevant data on age, gender, bone involved, specific area within the bone (location of the lesion-epiphysis, metaphysis, or diaphysis; cortex, medulla or periosteum), radiographic appearance are the basic parameters and key pieces of information necessary for the establishment of diagnosis [7].…”

“…The roentgenogram helps to define the exact location of the lesion and its aggressiveness; it reflects the gross manifestation of the lesion [5,8]. To establish an accurate diagnosis, an integrated approach toward these lesions is necessary for the form of clinical data, radiograph, and histopathology.…”

Histopathological evaluation of bone lesions in tertiary care centre

“…Bone lesions often pose diagnostic challenges to surgical pathologists. Therefore, an integrated approach involving radiographic, http://jmscr.igmpublication.org/home/ ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v8i1.22 histologic, and clinical data are necessary to form an accurate diagnosis and to determine the degree of activity and malignancy of each lesion 6 . Definitive clinical diagnosis of bone lesion is often difficult, so it is essential to identify the lesion correctly before deciding the line of treatment, be it simple currettement, excision surgery, amputation or irradiation 7 .…”