Histopathological effects of ethyl 2-cyanoacrylate tissue adhesive following surgical application: an experimental study

Kaplan, Mehmet; Bozkurt, Süheyla; Kut, Mustafa Sinan; Küllü, Sevgi; Demirtaş, Mahmut Murat

doi:10.1016/j.ejcts.2003.11.016

Cited by 38 publications

(32 citation statements)

References 8 publications

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“…In the latter two groups, the adherences might be related to the toxicity of cyanoacrylate degradation by-products. (11,23) Although the presence of toxic residues 14 days after surgery has been previously reported, (21) no adhesive residues were found 30 days after surgery in the present study. The inflammatory reactions observed during the histopathological examination of the pulmonary fragments were more intense and numerous in the animals submitted to conventional suture with absorbable suture.…”

Section: Resultscontrasting

confidence: 52%

Adesivo cirúrgico de etil-2-cianoacrilato em lobectomia parcial em ratos

et al. 2011

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Objective: To determine the efficacy of ethyl 2-cyanoacrylate adhesive in repairing the lung parenchyma after partial lobectomy in rats, in terms of hemostasis/aerostasis, scarring, and surgical time. Methods: The study involved 30 Wistar rats, randomly divided into five groups (one control group and four study groups). In the study groups, the lung parenchyma was repaired with either cyanoacrylate adhesive or surgical suture following resection of a small or large fragment (25% or 50%, respectively) of the left caudal lung lobe. Results: Surgical time and hemostasis time were shorter in the two groups treated with the adhesive than in the two submitted to suture. There were no significant differences among the groups regarding specific lung compliance. Adherences and inflammatory reactions were more severe in the groups submitted to suture. Conclusions: In this study, the use of cyanoacrylate adhesive helped reduce the surgical time and the intensity of inflammatory reactions, as well as preserving lung compliance. Cyanoacrylate adhesives should be considered an option for lung parenchyma repair, decreasing the risk of complications after partial lobectomy in humans.Keywords: Lung; Pneumonectomy; Cyanoacrylates. ResumoObjetivo: Determinar experimentalmente a eficácia do adesivo cirúrgico de etil-2-cianoacrilato na reparação do parênquima pulmonar após lobectomias parciais em ratos em relação a hemostasia/aerostasia, cicatrização e tempo cirúrgico. Métodos: O estudo envolveu 30 ratos Wistar, divididos aleatoriamente em cinco grupos (grupo controle e quatro grupos de estudo. Nos grupos de estudo, o reparo do parênquima pulmonar foi realizado ou com o adesivo ou por sutura após lobectomia parcial de um fragmento pequeno ou grande (25% ou 50%, respectivamente) do lobo inferior caudal esquerdo. Resultados: O tempo cirúrgico e o tempo de hemostasia foram menores nos grupos submetidos ao uso do adesivo. Não houve diferenças significativas na complacência pulmonar específica entre os grupos. Aderências e reações inflamatórias foram mais severas nos grupos submetidos a sutura. Conclusões: Neste estudo, o uso de adesivo de cianoacrilato ajudou a reduzir o tempo cirúrgico e a intensidade de reações inflamatórias, assim como preservou a complacência pulmonar. Adesivos de cianoacrilato devem ser considerados como uma opção no reparo do parênquima pulmonar, diminuindo o risco de complicações após lobectomia parcial em humanos.

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Section: Resultscontrasting

confidence: 52%

Adesivo cirúrgico de etil-2-cianoacrilato em lobectomia parcial em ratos

et al. 2011

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“…These initial observations contradicted the findings in the literature that showed important differences in toxicity between ECA and OCA; but the exact toxic effect of ECA was not established. In one study, rats submitted to myocardial repair, and lung and aorta repair using polytetrafluoroethylene patch cuttings which were joined with ECA showed similar necrosis, granulomathosis and inflammatory reactions 15 . In rats, inflammation, tissue granulation, reactions to foreign substances and fibrosis were worse in ECA closings compared to BCA and sutures, although ECA was just as efficient in the final cicatrisation 8 .…”

Section: Discussionmentioning

confidence: 99%

“…In spite of the possible complications, many authors have considered ECA a safe bio-adhesive for use in vivo due to the qualities it shares with the other CAs such as its resistance to exuded actions, the ability to support up to a traction of 500g, fast polymerization, provisory toxicity and related effects, bactericide and hemostatic effects when applied to the wound 2,6,12 . Furthermore, many studies have suggested a more widespread use of ECA over other CAs due to its low cost, fast degradation and ample disposability 4,8,14,15 . These suggestions have prompted many professionals to use the derivative short chain as ECA in their clinical practice, in spite of the disposability of other products supposing that they are less toxic 11 .…”

Section: Discussionmentioning

confidence: 99%

“…One type of CA that has been considered a relatively good solution for wound closure in relation to other CAs and sutures 6,8,10 is ECA. It has been used satisfactorily in clinical procedures involving odontology, abdominal surgery, gynecology, gastrology, neurological surgery, maxillary surgery, orthopedics, plastic surgery, urology, vascular surgery, cardiac surgery, thoracic surgery, and legal medicine 4,[12][13][14][15] . Furthermore, ECA is not carcinogenic 11 , while another CA type metil cyanoacrilat monomerous (MCA, Eastman monomerous) in large doses caused sarcoma development in rats 16 .…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of suture and cyanoacrylates in skin closure of rats

Souza¹,

Oliveira²,

Soares³

et al. 2007

Acta Cir. Bras.

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Purpose:To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. Methods: Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the 3 rd , 7 th , 14 th or 21 st postoperative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis. Results: The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures. Conclusion: ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications. Key words: Tissue adhesives. Cyanoacrylates. Materials Testing. Rats. RESUMOObjetivo: Investigar a biocompatibilidade do etil-cianoacrilato (ECA) em fechamento de pele em ratos comparativamente ao octil-cianoacrilato (OCA) e à sutura. Métodos: Rattus norvegicus albinus (n=24) foram submetidos a três incisões, cada uma fechada por um dos métodos de síntese estudados. Quatro grupos (n=6) foram feitos, conforme o dia pós-operatório (DPO) em que foram eutanasiados: 3DPO, 7DPO,14DPO e 21DPO. Necrose, edema, eritema, dermatite, infecção, deiscência, alargamento cicatricial e custos foram os itens examinados; histopatologicamente avaliou-se epitelização, abertura profunda, reação de corpo estranho, resíduos de material de síntese, fibrose, reação inflamatória, deiscência e necrose. Resultados: Os adesivos apresentaram os maiores níveis de deiscências, e o ECA o custo mais baixo; nos demais itens, não houve diferenças. Histopatologia: A abertura profunda foi mais comum com o OCA; ECA foi o material mais encontrado em granulomas; os adesivos foram mais brandos que a sutura a partir do 7º DPO no quesito inflamação, enquanto que o ECA causou uma reação similar ao OCA; nos outros itens, ECA não apresentou diferença importante em relação ao OCA e à sutura. Conclusão: O ECA foi bem tolerado neste grupo de estudo, sem induzir necrose, reações alérgicas e infecção, apresentando diversas vantagens de uso em relação ao OCA e à sutura. Descritores: Adesivos Teciduais. Cianoacrilatos. Teste de Materiais. Ratos. -ORIGINAL ARTICLE Souza SC et al 310

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“…These agents are approved for external application only and are not to be used as internal tissue adhesive because of the reactions, toxicity [8] and carcinogenicity. In the maxillofacial field, it has been used for wound closure on extraction sockets, face, sinus perforation in sinus lift [9] gingivectomy, mucogingival flaps, biopsy, superficial oral ulcerations, recurrent multiple Aphthous ulcers and leukemia, and other sites in general surgery like axilla, lungs [10], hearts [11], scalp wounds [4], circumcision [12] and perineum, trocar sites [13], as a heamostatic means to control bleeding from skin graft [14], hair transplant donor sites, cleft lip repair [7,15] face lifts, blepharoplasty [16], brow lifts and other cosmetic surgeries and to do various anastomoses of intestine, arteries [11] and nerves [17].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study: Efficacy of Tissue Glue and Sutures after Impacted Mandibular Third Molar Removal

Joshi

Saluja

Mahindra

et al. 2011

J. Maxillofac. Oral Surg.

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Objective To compare the efficacy of cyanoacrylate (tissue glue) placement after surgical removal of impacted mandibular third molars. Materials and Methods Thirty patients with bilaterally impacted mandibular third molars were studied in this controlled clinical trial. One side closure after surgical removal of third molar was done with conventional sutures and other side with cyanoacrylate. Results The data analysis showed that postoperative bleeding with cyanoacrylate method was less significant than with suturing on the first and second day after surgery. There was no significant difference in the severity of pain between the two methods. Conclusion This study suggested that the efficacy of both, cyanoacrylate and suturing in wound closure were similar in the severity of pain, but use of cyanoacrylate showed better hemostasis.

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Histopathological effects of ethyl 2-cyanoacrylate tissue adhesive following surgical application: an experimental study

Cited by 38 publications

References 8 publications

Adesivo cirúrgico de etil-2-cianoacrilato em lobectomia parcial em ratos

Adesivo cirúrgico de etil-2-cianoacrilato em lobectomia parcial em ratos

Comparative study of suture and cyanoacrylates in skin closure of rats

A Comparative Study: Efficacy of Tissue Glue and Sutures after Impacted Mandibular Third Molar Removal

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