Adesivo cirúrgico de etil-2-cianoacrilato em lobectomia parcial em ratos

Abstract

Objective: To determine the efficacy of ethyl 2-cyanoacrylate adhesive in repairing the lung parenchyma after partial lobectomy in rats, in terms of hemostasis/aerostasis, scarring, and surgical time. Methods: The study involved 30 Wistar rats, randomly divided into five groups (one control group and four study groups). In the study groups, the lung parenchyma was repaired with either cyanoacrylate adhesive or surgical suture following resection of a small or large fragment (25% or 50%, respectively) of the left caudal lung lobe. Results: Surgical time and hemostasis time were shorter in the two groups treated with the adhesive than in the two submitted to suture. There were no significant differences among the groups regarding specific lung compliance. Adherences and inflammatory reactions were more severe in the groups submitted to suture. Conclusions: In this study, the use of cyanoacrylate adhesive helped reduce the surgical time and the intensity of inflammatory reactions, as well as preserving lung compliance. Cyanoacrylate adhesives should be considered an option for lung parenchyma repair, decreasing the risk of complications after partial lobectomy in humans.Keywords: Lung; Pneumonectomy; Cyanoacrylates. ResumoObjetivo: Determinar experimentalmente a eficácia do adesivo cirúrgico de etil-2-cianoacrilato na reparação do parênquima pulmonar após lobectomias parciais em ratos em relação a hemostasia/aerostasia, cicatrização e tempo cirúrgico. Métodos: O estudo envolveu 30 ratos Wistar, divididos aleatoriamente em cinco grupos (grupo controle e quatro grupos de estudo. Nos grupos de estudo, o reparo do parênquima pulmonar foi realizado ou com o adesivo ou por sutura após lobectomia parcial de um fragmento pequeno ou grande (25% ou 50%, respectivamente) do lobo inferior caudal esquerdo. Resultados: O tempo cirúrgico e o tempo de hemostasia foram menores nos grupos submetidos ao uso do adesivo. Não houve diferenças significativas na complacência pulmonar específica entre os grupos. Aderências e reações inflamatórias foram mais severas nos grupos submetidos a sutura. Conclusões: Neste estudo, o uso de adesivo de cianoacrilato ajudou a reduzir o tempo cirúrgico e a intensidade de reações inflamatórias, assim como preservou a complacência pulmonar. Adesivos de cianoacrilato devem ser considerados como uma opção no reparo do parênquima pulmonar, diminuindo o risco de complicações após lobectomia parcial em humanos.

Behaviour of the Biological Adhesives TachoSil®, GelitaSpon®, and a New Elastic Cyanoacrylate (Adhflex®) in Experimental Renal Trauma and Wound Healing

“…Taha et al [14] reported no differences in the number of adhesions in the group treated with biological adhesives versus standard sutures. Szkudlarek et al [43] compared ethyl-2-CyA to an absorbable suture after partial lung lobectomy in rats. They noted that the groups treated with the suture had more adhesions and more intense inflammatory reactions than the group treated with ethyl-2-CyA.…”

Comparison of Different Synthesis Methods After Partial Pulmonary Lobectomy in Dogs

“…In both cases, along the suture line, there was no leakage, except for a single laceration point lateral to the suture line. When the ventilatory pressure wasincreased, the tissue tension in the lobe was probably higher in certain points, which may have caused a punctual laceration, and consequent leakage of air 19,21,22 .…”

Publicações do Jornal Brasileiro de Pneumologia

“…There were three studies involving ex vivo experimental models. ( 13 - 15 ) The use of a surgical adhesive for lung repair after lobectomy was tested in rats, ( 16 ) the extracellular matrix of the rat trachea was examined, ( 17 ) an experimental rat model of pulmonary hypertension ( 18 ) was studied, and the use of a self-expanding tracheal stent was tested in rabbits. ( 19 ) Murine models of allergic response ( 20 ) and of protective ventilation strategies ( 21 ) were studied.…”