Histopathological effects of estrogen deficiency on larynx mucosa in ovariectomised rats

Sürmeli, Mehmet; Habesoglu, Tulay Erden; Habeşoğlu, Mehmet; Deveci, İldem; Eriman, Murat; Kınış, Vefa; Güneş, Pembegül; Egeli, Erol

doi:10.1007/s00405-010-1337-5

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…This was in agreement with our experiment results, in which castration caused a decrease in vocal cord ECM expression in the vocal fold lamina propria. Ovariectomy in rats causes histopathological changes in larynx mucosa, with subepithelial edema, inflammation, and cilia and goblet cell loss (49), whereas corticosteroid injection in rabbit vocal fold injury was found to reduce collagen deposition during acute wound healing (50). However, the details of the underlying mechanisms of these steroidal actions remain to be determined, and even the effects of steroid hormones on fibroblasts in the lamina propria of the vocal fold are not yet well understood.…”

Section: Discussionmentioning

confidence: 98%

Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus

et al. 2015

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There is accumulating evidence that fibroblasts are target cells for steroids such as sex hormones and corticoids. The characteristics of fibroblasts vary among tissues and organs. Our aim in this study is to examine differences in responses to steroid hormones among fibroblasts from different cervicothoracic regions. We compared the actions of steroid hormones on cultured fibroblasts from the vocal folds, which are considered to be the primary target of steroid hormones, and the trachea and esophagus in adult male rats. Expression of steroid hormone receptors (androgen receptor, estrogen receptor α, and glucocorticoid receptor) was identified by immunofluorescence histochemistry. Androgen receptor was much more frequently expressed in fibroblasts from the vocal fold than in those from the trachea and esophagus. Cell proliferation analysis showed that administration of testosterone, estradiol, or corticosterone suppressed growth of all 3 types of fibroblasts. However, mRNA expression for extracellular matrix-associated genes, including procollagen I and III and elastin, and hyaluronic acid synthase I was elevated only by addition of testosterone to fibroblasts from the vocal fold. These results indicate that each steroid hormone exerts region-specific effects on cervicothoracic fibroblasts with different properties through binding to specific receptors.

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Section: Discussionmentioning

confidence: 98%

Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus

et al. 2015

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“…Furthermore, the vocal epithelium cytologic smears of bilateral ovariectomized women without ERT revealed aspects of atrophy‐dystrophy 4. Animal experiments also found that estrogen deficiency could cause histologic changes in the larynx, including subepithelial edema, inflammation,6 and induced epithelial cell layers 7…”

Section: Introductionmentioning

confidence: 98%

Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer

Tian

Suzuki

Nakajima

et al. 2008

Cancer

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BACKGROUND.The expression of prostaglandin E receptor 2 (PTGER2) affects the biologic behavior of various types of malignant tumors. Recently, transactivation of both PTGER2 and epidermal growth factor receptor (EGFR) has been reported in some tumors.METHODS.PTGER2 gene expression and possible aberrant methylation of the PTGER2 gene were investigated in 10 nonsmall cell lung cancer (NSCLC) cell lines, 233 primary tumors, and 168 adjacent nonmalignant lung tissues. They were analyzed with reference to an association with EGFR mutation in 133 clinical lung adenocarcinomas and were correlated with patient survival.RESULTS.Down‐regulation of PTGER2 expression was observed in 8 of 10 NSCLC cell lines. Demethylation of 5 expression‐negative cell lines restored the expression of PTGER2. Aberrant methylation of the PTGER2 gene was reversely concordant with its messenger RNA expression. PTGER2 methylation was detected in 137 of 233 NSCLC specimens (58%) but was detected in only 2 of 168 nonmalignant lung tissues (1%). Both NSCLCs and adenocarcinomas that had PTGER2 methylation predicted a significantly better prognosis than those without PTGER2 methylation (P = .0051 and P = .0171, respectively). PTGER2 methylation was present with greater frequency in tumors with EGFR mutation than in non‐EGFR mutated tumors (P = .0095), and the significance of the correlation was independent after adjusting for sex and smoking status (P = .0144).CONCLUSIONS.Aberrant methylation of the PTGER2 gene was observed frequently in NSCLC tissues and was associated with the presence of EGFR mutation and a better prognosis. Cancer 2008. © 2008 American Cancer Society.

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“…[11,12]. In another study, the impact of menopause on the female rat larynx in ovariectomized animals was presented histopathologically [13]. Just like menopause, polycystic ovary syndrome (PCOS) also modiWes hormone proWle in women.…”

Section: Introductionmentioning

confidence: 92%

Histological evaluation of rat larynx in experimental polycystic ovary syndrome model

Deveci

Deveci²,

Habeşoğlu

et al. 2012

Eur Arch Otorhinolaryngol

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This study aimed at studying the histopathological effects of hyperandrogenemia and estrogen deficiency on larynx mucosa in experimentally designed polycystic ovary syndrome of female rats. Two groups of experimental polycystic ovary syndrome model were composed in healthy female rats by per oral letrozole administration of for 21 and 42 days. Also a control group which only took vehicle (saline) for 42 days was designed. Laryngeal mucosa and ovaries of all animals were examined histopathologically by light microscopy and the serum hormone levels were analyzed using a solid-phase, two-site chemiluminescent enzyme immunometric assay. Statistically significant edema, vascular engorgement, inflammation, cilia loss and differentiation of goblet cell distribution were observed when the control group and study groups were compared (p < 0.01). In serum hormonal analysis there was a significant increase in levels of androgens and decrease in levels of estrogens. In addition, polycystic appearance of ovaries in letrozole-administered groups and normal appearance of ovaries in control group have been proven histopathologically. Polycystic ovary syndrome which causes estrogen deficiency and hyperandrogenemia in fertile ages resulted in histopathological changes in laryngeal mucosa.

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Histopathological effects of estrogen deficiency on larynx mucosa in ovariectomised rats

Cited by 10 publications

References 23 publications

Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus

Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus

Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer

Histological evaluation of rat larynx in experimental polycystic ovary syndrome model

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