Histopathological effects of doxorubicin on kidneys in rats

Ali, Iftikhar; Jumaa, Hamad J.

doi:10.33899/ijvs.2014.89342

Cited by 2 publications

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“…for the group treated with doxorubicin drug, including thickening of the basement membrane, metaplasia of the epithelial lining of the tubules, bowman space expansion, complete dissolution in the lining of tubules and necrosis of medulla tubules, expansion of their lumen (figure2-H,I,J). High dose of doxorubicin causes acute toxic side effects in kidney tissue which in turn induced nephrotoxicity [29,33,34,35,36] . In addition , doxorubicin drug causes cell damage due to oxidative stress and this is consistent with [32] .…”

Section: Different Pathological Changes Have Been Observedmentioning

confidence: 99%

Physiological and Histological Study of Doxorubicin Effect on Kidney Tissue in Cancer Induced Rats

Sundus W. Alabdullah,

Majid N. Humoud

2021

Indian Journal of Forensic Medicine & Toxicology

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Doxorubicin (Adriamycin) is one of the chemical drugs commonly used worldwide for the treatment of various types of cancer , and high doses of it cause unwanted toxic side effects on the kidney. This study aims to demonstrate the physiological and histopathological effect of the doxorubicin drug on kidney of rats. For this purpose , twenty adults male were used in this study and were divided equally into four groups (A: control group, B: a group treated with the carcinogen only , C: a group treated with the carcinogen and doxorubicin and D: a group treated with doxorubicin only). Five rats were included in each group and the cancer was developed by injection with azoxymethane once a week for the B and C groups. Compared to the other groups, there was a significant decrease in the weights of animals for the carcinogen-treated group. The concentrations of the hematological parameters of the groups, such as Hb, PCV as well as some tests related to the kidney functions like the concentration of urea , uric acid ,albumin ,globulin, creatinine and total protein were measured and it was found differences between these three groups in term of these testes compared with control group. Regarding to the histological examination of the kidney present study showed specific tissue changes in the treated-carcinogen groups , such as lymphocytes infiltration , glomeruli condense , destroyed of urinary tubules in addition to the presence of bleeding. As for the group treated with doxorubicin , pathological changes were observed include, destroyed of glomerular basement membrane , glomeruli and urinary tubules.

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Section: Different Pathological Changes Have Been Observedmentioning

confidence: 99%

Physiological and Histological Study of Doxorubicin Effect on Kidney Tissue in Cancer Induced Rats

Sundus W. Alabdullah,

Majid N. Humoud

2021

Indian Journal of Forensic Medicine & Toxicology

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The Effect of Dosing with Lemon Juice on the Renal Tissue of Laboratory Rats with Kidney Stones (Urolithiasis/ Nephrolithiasis) Experimentally

Abd,

Saeed

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Kidney stones and renal tissue damage are common diseases that are affected by many causes, including nutritional causes. There have been many ways to treat kidney disease and ways to prevent it through appropriate diets. The research aimed to study the effectiveness of lemon juice in preventing kidney disease in laboratory rats. As 15 animals were distributed in three groups, the first was considered a control group that was dosed with distilled water and the other group was dosed with ethylene glycol as a cause of kidney injury, while lemon juice was used to treat the latter. It was found through the histological sections of the kidneys that the lemon extract helped to preserve the kidneys of the animals, as the glomeruli appeared regularly with the integrity of the epithelial cells of the renal tubules. It was found that the rates of damage to the renal glomeruli in the group treated with lemon did not differ significantly from the animals that were not exposed to infection (the control group). And the damage rate is about 22%. The percentage of damage to the glomeruli in the histological sections of animals that were dosed with the causative agent of stone formation (ethylene glycol) and not treated was about 75%, as the results of histological cutting indicated that they contained atrophy in the renal glomeruli with dissection of Bowman’s capsule and hemorrhage on the surface with calcium crystals deposits.

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Histopathological effects of doxorubicin on kidneys in rats

Cited by 2 publications

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Physiological and Histological Study of Doxorubicin Effect on Kidney Tissue in Cancer Induced Rats

Physiological and Histological Study of Doxorubicin Effect on Kidney Tissue in Cancer Induced Rats

The Effect of Dosing with Lemon Juice on the Renal Tissue of Laboratory Rats with Kidney Stones (Urolithiasis/ Nephrolithiasis) Experimentally

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