Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos

Barwarei, Baidaa

doi:10.33899/ijvs.2019.125467.1006

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…However, MDA, aspartate aminotransferase, and alanine aminotransferase were all dramatically reduced (22). The histopathological studies are represented by tissue slices of mice aorta at the end of the study to further confirm the outcome (18,23). Fatty diet has induced atherosclerotic changes compared to the control group on a regular diet.…”

Section: Discussionmentioning

confidence: 92%

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Hamed¹,

Abed²,

Almashhadany³

et al. 2022

IJVS

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Herbal products are increasingly used against lipid to attenuate its negative impact on vasculature system. However, there are uncertainty regarding the best administration approaches and preparation of herbal product to be used due to variation in absorption rate and extent with subsequent impaction on the lipid levels. The aim of the present study was comparing the pharmacological and analytical aspects of soaked versus powder form of Hypericum perforatum; a well-known anti-hyperlipidemic herbal product, using atorvastatin drug as a reference drug for comparison in addition to controlling groups (on/off lipid diet) handled as an additional control group. To conduct this research, the hyperlipidemia mice models were created by exposing the mice to a fatty diet and using H. perforatum and atorvastatin for evaluation. The plant extracts were also analyzed for active constituents. The results indicate that the plant analysis detected the presence of different antihyperlipidemic agents and the plant has effectively reduced plasma lipid parameters in exposed mice compared to control group; especially when taken forms of the plant was used. The study concluded that; soaked H. perforatum extract shown an effective reduction of lipid parameters and analysis of which revealed the presence of herbal active constituent which might be utilized in industrial pharmacy for new drug innovation.

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Section: Discussionmentioning

confidence: 92%

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Hamed¹,

Abed²,

Almashhadany³

et al. 2022

IJVS

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“…With the involvement of cytochrome P-450, electrophilic intermediates metabolite have produced that bind covalently to macromolecules of the cell which disturb mitochondrial and nuclear roles triggering the development of ROS and protein oxidation (14). The body's inability to remove the ROS promptly via the antioxidant mechanism lead to oxidative stress (15). ROS are considered to be responsible for destroying the membrane of the mitochondria and releasing Cyt C (16).…”

Section: Discussionmentioning

confidence: 99%

Hepato-renal and hematological effects of flunixin and silymarin coadministration in rats

Mohammed¹,

Shaban²,

Albadrany³

2022

IJVS

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The study aimed to explore the ameliorative effects of silymarin when administered with flunixin on the liver, kidney, and blood components in rats. The animals were divided into four groups; each one consists of five rats. The first group was served as a control. The second and third groups were treated with silymarin 200 mg/kg b.wt, p.o and flunixin 2.5 mg/kg b.wt, i.p respectively. The fourth group was treated with silymarin and flunixin concurrently. The involved rats were treated for seven consecutive days by a single daily dose. Following the treatment, the biochemical analysis ALT, AST, ALP, Urea, and Creatinine, blood analysis parameters RBC, HGB, HCT, WBC, and PLT, and a histopathological examination liver and kidney were studied for the involved animals. The results showed that flunixin increased the levels of ALT and AST and the concentrations of Urea and Creatinine, and the total number of WBC. Also silymarin caused a remarkable decrease in the flunixin adverse effects on the liver and kidneys. This was reflected from the histological features observed from the diverse tested groups. Based on these findings, the authors concluded that silymarin has the ability to reduce the harmful effects of flunixin on both the liver and the kidneys.

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“…Acetaminophen is capable to activate the neuronal CYP2E1 thus producing toxic substances during metabolism as NAPQI (that decrease the level of glutathione and causing neurotoxicity and oxidative stress) (1), besides that, acetaminophen with overdose decreased the levels of anti-oxidants like glutathione, ascorbic acid with a relation to a significant reduction in the activity of superoxide dismutase (SOD). The important over creation of reactive oxygen species (ROS) in brain and the imbalance between oxidative stress and antioxidants are related with pathologic alterations neurodegenerative disorders (4,(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Histological changes of CA and DG regions of hippocampus of rats’ brain after exposure to Acetaminophen in postnatal period

Hussin¹,

Khalel²

2021

IJVS

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Authors reported that exposure to acetaminophen postnatally may be linked to increasing the risk of ASD. However, the reports on its effects on the brain are scanty, and the knowledge concerning their safety is little as there is a traditional left out of the clinical trials by users. The present work tried to elucidate the histological effects of acetaminophen on the hippocampus of neonate male rats after early postnatal exposure. The pups were categorized into2 groups, the control group, and the acetaminophen treated group. The acetaminophen treated animals were injected subcutaneously with acetaminophen of 60 mg/Kg/day from postnatal day (PND) 7 to PND 14, while the control group treated with normal saline with a similar approach. The histopathologic assessment revealed a diminishing in the pyramidal cells layer thickness of Cornue Ammonis. Some areas are devoid of cells with the appearance of Ghost like cells indicating features of neural cell death, degenerated neurons in the pyramidal layer are noticed. Features of nuclear clumping of pyramidal cell layer were shown. Moreover, several changes including vacuolations in the granular layer of DG with disorganization in DG. Neuronal processes presented with clumping. Apoptosis in the granular cells layer and hilus of a section of DG with the appearance of many astrocytes and microglial cells. Exposures to clinically relevant doses of acetaminophen in the postnatal period were shown to affect the histology of rat hippocampal regions, and a balanced risk assessment based on the best professional judgment must be prioritized.

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Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos

Cited by 7 publications

References 26 publications

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Hepato-renal and hematological effects of flunixin and silymarin coadministration in rats

Histological changes of CA and DG regions of hippocampus of rats’ brain after exposure to Acetaminophen in postnatal period

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