Histopathological characteristics of explanted human prosthetic arterial grafts: Implications for the prevention and management of graft infection

Abstract

This data cast doubt on criteria commonly used to distinguish graft infections and host vs. graft reactions from normal graft healing. Acute and chronic inflammation are not predictive of infection.

Neutrophil survival on biomaterials is determined by surface topography

“…Bacteria were always localized on the outside and never on the luminal surface of the grafts. 42 These data suggest that the encounter between bacteria and phagocytes likely occurs on the outer surface of the graft in a static environment.…”

Pathology of cardiovascular interventions and surgery

“…32,33 Several options have been proposed to treat this problem, including using allo-and auto-grafts, and more recently, Rifampicin-bounded and Silver-coated synthetic vascular grafts.…”

Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery

“…Second, the ePTFE induces a foreign body inflammatory response noted as accumulation of macrophages and T cells. 7, 8 We have therefore tested the hypothesis that the iliac artery will undergo atrophy in response to a reduction of wall stress and the addition of inflammatory stimuli by using a ePTFE wrap.…”

“…Second, the ePTFE induces a foreign body inflammatory response noted as accumulation of macrophages and T cells. 7, 8 We have therefore tested the hypothesis that the iliac artery will undergo atrophy in response to a reduction of wall stress and the addition of inflammatory stimuli by using a ePTFE wrap. vided by W. L. Gore & Associates Inc, Flagstaff, Ariz) graft material were used to wrap the external iliac arteries of 10 male baboons as shown in Fig 1. The tightly wrapped segment was made by wrapping the collapsed artery and a 2.5-mm-diameter rod together and removing the rod after sewing together the edges of the graft material; the loosely wrapped segment was left unsewn.…”