Pathology of cardiovascular interventions and surgery

Li, Alice Y.; Law, Kelsey B.; Phillips, Katherine G.; Nwachukwu, Harriet; Butany, Jagdish; Gotlieb, Avrum I.

doi:10.1016/j.mpdhp.2009.10.003

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…In doing so, the stent induces stress fields on the artery wall which have been implicated in promoting vascular injury resulting in restenosis. 7 The length and the number of implanted stents seem to be associated with more probable restenosis at the 6-month angiographic evaluation. 19 Restenosis also appears to be associated with systemic markers of inflammation, such as midkine which may have an important role in the intimal hyperplasia caused by BMS implantation through macrophage accumulation.…”

Section: Metals For Stentsmentioning

confidence: 93%

“…PCI is now carried out almost exclusively with the insertion of a stent. PCI has improved clinical outcomes in high‐risk patients with acute coronary syndromes and stent thrombosis (ST)‐elevation myocardial infarction, using a catheter‐based approach to revascularize the coronary arteries that are significantly compromised by atherosclerotic plaques . The widespread use of stents in PCI has improved the safety and efficacy of these procedures.…”

Section: Introductionmentioning

confidence: 99%

“…For example, the stent must have sufficient radial strength to keep open the diseased atherosclerotic artery. In doing so, the stent induces stress fields on the artery wall which have been implicated in promoting vascular injury resulting in restenosis . The length and the number of implanted stents seem to be associated with more probable restenosis at the 6‐month angiographic evaluation .…”

Section: Introductionmentioning

confidence: 99%

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Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization

Zhang

Liu

et al. 2013

J Biomedical Materials Res

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Driven by the complications occurring with bare metal stents and drug-eluting stents, concerns have been raised over strategies for long-term safety, with respect to preventing or inhibiting stent thrombosis, restenosis, and in-stent restenosis in particularly. Surface modification is very important in constructing a buffer layer at the interface of the organic and inorganic materials and in ultimately obtaining long-term biocompatibility. In this review, we summarize the developments in surface modification of implanted cardiovascular metal stents. This review focuses on the modification of metal stents via coating drugs or biomolecules to enhance antithrombosis, antirestenosis, and/or endothelialization. In addition, we indicate the probable future work involving the modification of the metallic blood-contacting surfaces of stents and other cardiovascular devices that are under development.

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Section: Metals For Stentsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization

Zhang

Liu

et al. 2013

J Biomedical Materials Res

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“…Stents are used in percutaneous coronary intervention to restore blood flow in patients with coronary artery disease (CAD) which is characterized by the occlusion of a coronary artery due to plaque formation ( Garg and Serruys, 2010 ; Li et al, 2010 ). Researchers are dedicated to the development of new biocompatible materials for use in stent devices, that on the one hand provide enough strength for vessel support during constrictive re-modeling while also allowing for good cyto- and hemocompatibility ( Van Oeveren et al, 1999 ; Williams, 2008 ; Huang et al, 2014 ; Zhang et al, 2014 ; Blok et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility Evaluation of a Novel Series of PEG-Functionalized Lactide-Caprolactone Copolymer Biomaterials for Cardiovascular Applications

Pacharra

McMahon²,

Duffy³

et al. 2020

Front. Bioeng. Biotechnol.

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Pacharra et al. Cytocompatible PLCL-PEG Copolymers for Cardiovascular Applications best endothelial cell adhesion. PLLA-PEG550 and PLCL-PEG550 70:30 presented as best candidates for cardiovascular implant use from a cytocompatibility perspective across the spectrum of testing completed. Altogether, these polymers are excellent innovative materials suited for an application in stent manufacture due to the ease in translation of this one-step synthesis strategy to device production and their excellent in vitro cyto-and hemocompatibility.

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Surface patterning of a novel PEG‐functionalized poly‐l‐lactide polymer to improve its biocompatibility: Applications to bioresorbable vascular stents

et al. 2018

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Today, research in the field of bioresorbable vascular stents (BVS) not only focusses on a new material being nontoxic but also tries to enhance its biocompatibility in terms of endothelialization potential and hemocompatibility. To this end, we used picosecond laser ablation technology as a single-step and contactless method for surface microstructuring of a bioresorbable polymer which can be utilized in stent manufacture. The method works on all materials via fast material removal, can be easily adapted for micropatterning of tubular or more complex sample shapes and scaled up by means of micropatterning of metal molds for manufacturing. Here, picosecond laser ablation was applied to a bioresorbable, biologically inactive and polyethylene glycol-modified poly-L-lactide polymer (PEGylated PLLA) to generate parallel microgrooves with varying geometries. The different patterns were thoroughly evaluated by a series of cyto- and hemocompatibility tests revealing that all surfaces were non-toxic and non-hemolytic. More importantly, patterns with 20 to 25 µm wide and 6 to 7 µm deep grooves significantly enhanced endothelial cell adhesion in comparison to samples with smaller grooves. Here, human cardiac microvascular endothelial cells were found to align along the groove direction, which is thought to encourage endothelialization of intraluminal surfaces of BVS. © 2018 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 00B: 000-000, 2018.

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Pathology of cardiovascular interventions and surgery

Cited by 5 publications

References 62 publications

Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization

Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization

Cytocompatibility Evaluation of a Novel Series of PEG-Functionalized Lactide-Caprolactone Copolymer Biomaterials for Cardiovascular Applications

Surface patterning of a novel PEG‐functionalized poly‐l‐lactide polymer to improve its biocompatibility: Applications to bioresorbable vascular stents

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