Histopathological changes of rat larynx mucosa with exposure to chronic thinner inhalation

Abstract

On the basis of histopathological evaluations, it was shown that the harmful effect of inhalation of thinner in high concentrations to larynx mucosa is similar to the effect on other organs of the respiratory system.

Effects of Ovariectomy and Estrogen Replacement Therapy on Laryngeal Tissue

“…To qualitatively evaluate the severity of inflammation, hyperplasia of the epidermidis, amount of exudate on the epithelial surface, extent of thickening of the dermis, blood and lymph vessel dilation, and infiltration of polymorphonuclear leucocytes (PMNLs) and lymphocytes were taken into account. They were graded as +, mild inflammation (infiltration of few PMNLs and lymphocytes); ++, moderate inflammation (infiltration of some PMNLs and lymphocytes); and +++, severe inflammation (infiltration of many PMNLs and lymphocytes) 14 . Edema, vascular dilation, and pseudostratification were also graded as mild (+), moderate (++), or severe (+++).…”

“…They were graded as +, mild inflammation (infiltration of few PMNLs and lymphocytes); ++, moderate inflammation (infiltration of some PMNLs and lymphocytes); and +++, severe inflammation (infiltration of many PMNLs and lymphocytes). 14 Edema, vascular dilation, and pseudostratification were also graded as mild (+), moderate (++), or severe (+++). Cilia loss was evaluated morphologically by light microscopy.…”

The effect of antimicrobial photodynamic therapy on human ciliated respiratory mucosa

“…The use of light microscopy to determine the effects of various chemicals and treatments on the histomorphologic structure of nasal and sinus‐ciliated respiratory epithelium is well established in the literature 35–40. In addition, any changes in the histomorphologic structure of the paranasal sinus epithelium has correlated with functional sinus mucosal changes, such as a change in ciliary beat frequency 35–40. Furthermore, the human highly differentiated ciliated respiratory EpiAirway tissues used in this study are ideal for basic cell and molecular biology studies, pharmaceutical target validation, and preclinical toxicity/efficacy determination, as well as inhalation toxicity studies of occupational or environmental air pollutants and toxins 25.…”