Histopathological Changes in Siderosis Bulbi

Evaluation of retinal integrity in eyes with retained intraocular metallic foreign body by ERG and EOG

“…As in previous reports [9,10], the variety of electrophysiological changes in metallosis bulbi was also seen in these three cases. Case 1 had changes in the b-wave, the OPs and the bicarbonate response, Case 2 only in the bicarbonate response and Case 3 in the b-wave and the OPs.…”

“…According to Duke-Elder [6] and Declercq et al [11], the initial lesion in siderosis bulbi occurred in the inner retinal layers, while Masciulli et al [12] insisted on its outer retinal origin. Factors influencing the site of initial lesion could be (1) the histoaffinity of the metal ion [4, 6], (2) diffusional pathway of the metal ion [9], and (3) location of the foreign body. Appel et al [9] hypothesized two diffusional pathways of iron ions, namely suprachoroidal and vitreal pathways, based on histopathological findings in siderosis bulbi.…”

“…Factors influencing the site of initial lesion could be (1) the histoaffinity of the metal ion [4, 6], (2) diffusional pathway of the metal ion [9], and (3) location of the foreign body. Appel et al [9] hypothesized two diffusional pathways of iron ions, namely suprachoroidal and vitreal pathways, based on histopathological findings in siderosis bulbi. The selective diminution of the bicarbonate response in Case 2 may have been a manifestation of the RPE damage via the suprachoroidal pathway.…”

Experimental Investigations on the Penetration into the Eyeball of Iron Administered Intraorbitally

“…Anatomopathological examination of eyeballs of pa tients suffering from siderosis caused by an intrabulbar foreign body has demonstrated that iron readily passes from the anterior chamber into the suprachoroidal space even in early stages of the disease [1]. The concen tration of iron in the retina can be somewhat lower than in the anterior chamber because Bruch's membrane is a barrier which to a certain degree obstructs the penetration of the metal deeper into the eye [2], The question remains whether the amounts of iron found by us in the aqueous can cause damage to the ocular tissues.…”

Ultrasound biomicroscopy in two cases of ocular siderosis with secondary glaucoma

“…The aetiopathogenesis of secondary open‐angle glaucoma related to ocular siderosis has often been ascribed to trabecular fibrosclerosis, probably because of the direct toxic effect of iron ions (Appel & Barishak 1978). In the first presented case, severe glaucoma developed 2 months after the trauma with the metal foreign body still in the eye.…”