Evaluation of retinal integrity in eyes with retained intraocular metallic foreign body by ERG and EOG

Tanabe, J; Shirao, Yutaka; Oda, Noriko; Kawasaki, Kazuo

doi:10.1007/bf00160133

Cited by 14 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2005a). Interestingly, such an increase of the b‐wave response is also reported from human eye, when they retain an intraocular metallic foreign body (Tanabe et al. 1992).…”

Section: Discussionmentioning

confidence: 59%

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl₂‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Siapich

Banat

Albanna

et al. 2009

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: NiCl 2 (15 lM) stimulates the electroretinogram (ERG) b-wave amplitude of vertebrate retina up to 1.5-fold through its blocking of E ⁄ R-type voltage-gated Ca 2+ channels. Assuming that such an increase is mediated by blocking the release of the inhibitory neurotransmitter c-aminobutyric acid (GABA) via ionotropic GABA receptors, we tested the effect of both GABA itself and GABA-receptor antagonists such as ())bicuculline (1.51-fold increase) and (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA; 1.46-fold increase) on the b-wave amplitude. Methods: Recording of the transretinal potentials from the isolated bovine retina. Results: GABA (100 lM) reduced the b-wave amplitude only when NiCl 2 (15 lM) was applied first. Each antagonist applied on its own stimulated the b-wave amplitude only partially: subsequent NiCl 2 superfusion caused a small but additional increase, leading to a 1.69-and a 1.88-fold total increase of the amplitude by Ni 2+ plus ())bicuculline or Ni 2+ plus TPMPA, respectively. Only the application of both antagonists in combination, before superfusing low NiCl 2 (15 lM), completely prevented subsequent stimulation by NiCl 2 with a similar 1.90-fold total increase of b-wave amplitude. Those retina segments that did not respond to NiCl 2 could not be stimulated by ())bicuculline and vice versa. Conclusion: The stimulatory effect of NiCl 2 on the ERG b-wave amplitude is mainly, but not only, mediated by a NiCl 2 -sensitive, Ca v 2.3-triggered GABA release acting through ionotropic GABA-A and GABA-C receptors.

show abstract

“…2005a). Interestingly, such an increase of the b‐wave response is also reported from human eye, when they retain an intraocular metallic foreign body (Tanabe et al. 1992).…”

Section: Discussionmentioning

confidence: 59%

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl₂‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Siapich

Banat

Albanna

et al. 2009

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…3B). The exact reason why the eyes with severe NPDR tended to have larger amplitudes was not determined, but several past studies have shown that the retinas with some degrees of ischemia28293031323334 or hyperglycemia35 can have supernormal full-field ERG amplitudes. The changes in the retinal circulation or neuronal activity due to the DR may be responsible for the relatively larger amplitudes in the eyes with severe NPDR.…”

Section: Discussionmentioning

confidence: 99%

Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device

Fukuo

Kondo

Hirose

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Therefore, it is important to detect DR accurately during mass screening. The purpose of this study was to determine whether a small, hand-held, mydriasis-free, full-field flicker electroretinographic (ERGs) device called RETeval can be used to screen for DR. To accomplish this, we recorded full-field flicker ERGs with this device from 48 normal eyes and 118 eyes with different severities of DR in patients with diabetes mellitus (DM). This system delivered a constant flash retinal luminance by adjusting the flash luminance that compensated for changes in the pupil size. Our results showed that there were significant correlations between the severity of DR and the implicit times (P < 0.001; r = 0.55) and the amplitudes (P = 0.001; r = −0.29). When the implicit time was used for the index, the area under the receiver operating characteristic curve was 0.84 for the detection of DR, and was 0.89 for the detection of DR requiring ophthalmic treatments. These results suggest that the implicit times of the flicker ERGs recorded by the small, mydryasis-free ERG system can be used as an adjunctive tool to screen for DR.

show abstract

“…It seems likely that both acetylcholine and adrenergic systems may have modulatory functions in the retina and could conceivably affect neuronal systems that could influence the generators of the a- and b-waves either directly or indirectly which may have been unmasked with the use of K+X anesthesia. The possibility of systemic effects on the ERG following these pharmacological combinations cannot be ruled out, given the fact that substances such as corticosteroids or high levels of carbon dioxide can lead to an augmented ERG response 62, 63.…”

Section: Discussionmentioning

confidence: 99%

Topical Mydriatics Affect Light-Evoked Retinal Responses in Anesthetized Mice

Mojumder

Wensel

2010

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose To characterize effects of muscarinic antagonist, atropine (A), and α-adrenergic agonist, phenylephrine (P), on mydriasis and light-evoked signaling in mice anesthetized by ketamine and xylazine (K+X). Methods Pupillary areas of anesthetized C57BL/6 mice were measured with or without topical application of either A or A+P. Dark-adapted ERGs were recorded from 2–4 month old C57BL/6 and 7.5 month old albino hrhoG/hrhoG mice following application of A or P singly or in combination before or after induction of K+X anesthesia. Effects of GABA were tested in the hrhoG/hrhoG mice. Results K+X anesthesia resulted in maximal mydriasis that was not enhanced by A or A + P. Dark-adapted b-wave amplitudes (−1.3 log sc td s) after K+X anesthesia were similar with or without A or P. A+P in the presence of K+X produced a slow growth in b-wave amplitude, reaching a plateau of two-fold enhancement in 1 h. Recordings with varying flash-energies revealed that the effects of A + P were on the maximum amplitude of the a- and b-waves and not on their sensitivity. Scotopic threshold responses were augmented as well. In photoreceptor-degenerated mice (hrhoG/hrhoG), an electronegative ERG wave recorded with K + X or K + X + A, was converted to a GABA-sensitive response with two electropositive components with A+P after K + X. Conclusion Topical administration of A, and P together, but not separately in presence of K+X, leads to a slow, dramatic enhancement of a- and b-waves by an unknown mechanism independent of pupil dilatation.

show abstract

Evaluation of retinal integrity in eyes with retained intraocular metallic foreign body by ERG and EOG

Cited by 14 publications

References 5 publications

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl₂‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl₂‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device

Topical Mydriatics Affect Light-Evoked Retinal Responses in Anesthetized Mice

Contact Info

Product

Resources

About

Evaluation of retinal integrity in eyes with retained intraocular metallic foreign body by ERG and EOG

Cited by 14 publications

References 5 publications

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl2‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl2‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device

Topical Mydriatics Affect Light-Evoked Retinal Responses in Anesthetized Mice

Contact Info

Product

Resources

About

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl₂‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina

Antagonists of ionotropic γ‐aminobutyric acid receptors impair the NiCl₂‐mediated stimulation of the electroretinogram b‐wave amplitude from the isolated superfused vertebrate retina