Histopathological changes in rat myocardium caused by Vipera ammodytes ammodytes (European viper) snake venom

Unković-Cvetković, Nadežda; Cvetković, M; Petkovic, D.; Jovanović, Tatjana; Unković, S

doi:10.1016/0041-0101(83)90099-5

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…Several isoforms of PLA 2 have been identified [8][9][10] that may explain variable toxicities of venoms from different genera of snakes. PLA 2 from snake venom has been implicated in multiple pathologies including neurotoxicity [11], nephrotoxicity [12,13], lung toxicity [14], hepatotoxicity [15], and cardiotoxicity [16,17]. Recently, scorpion envenomation has also been shown to produce significant lipid peroxidation in heart, lung, liver, and kidney of rodents [18].…”

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confidence: 99%

Time-course of lipid peroxidation in different organs of mice treated withEchis pyramidum snake venom

Asmari

Moutaery

Manthari

et al. 2006

J. Biochem. Mol. Toxicol.

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This study examined the effect of Echis pyramidum (EP) venom on time-course of lipid peroxidation in different vital organs of mice. Adult male Swiss albino mice were injected with EP venom (2 mg/kg, i.p.); control mice received vehicle alone (normal saline). Mice were killed at 1, 3, 6, 12, and 24 h post-envenomation. The liver, lung, kidney, heart, and brain (cerebrum and cerebellum) were collected for the estimation of malondialdehyde (MDA), an index of lipid peroxidation. The results of this study showed that a single injection of EP venom caused a significant lipid peroxidation in all the organs studied. The onset of lipid peroxidation was as early as 1 h and persisted for several hours, suggesting an important role of oxidative stress in the cytotoxicity of EP venom.

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mentioning

confidence: 99%

Time-course of lipid peroxidation in different organs of mice treated withEchis pyramidum snake venom

Asmari

Moutaery

Manthari

et al. 2006

J. Biochem. Mol. Toxicol.

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“…9 Bitis arietans species is responsible for more snakebite fatalities than any other African snake largely owing to its wide distribution, common occurrence, size, potent venom being produced in large amounts and their frequent encounter with humans. [10][11][12] The cytotoxic venom 13 is one of the most toxic in the viperidae family. In humans, bites from this species can produce severe local and systemic symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15] Serious bites results in significant hemorrhage or coagulation in the affected muscles. [10][11][12] The fatality rate highly depends on the severity of the bites and some other factors. Most fatalities are associated with poor clinical management and neglect.…”

Section: Introductionmentioning

confidence: 99%

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2016

MOJT

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Snake bite is one of the major causes of death around the globe and a major clinical concern due to improper prognosis as a result of the unavailability of research data. The effect of one sub-lethal dose (4mg/kg body weight) of Bitis arietans crude venom on serum solute/trace element levels and various markers for tissue damage in rat liver have been investigated. Bitis arietans venom caused significant perturbation in the serum levels of electrolytes sodium and potassium and also in the copper: zinc ratio. There was profound hepatotoxicity and nephrotoxicity as evident by increased levels of marker enzymes AST and metabolites creatinine and blood urea nitrogen. This was associated with significant increase in the levels of lipid peroxidation in the liver and concomitant perturbation in the antioxidant enzyme activities. When vitamin C (50mg/kg body weight) was given along with the venom we witnessed a significant ameliorative effect. There was marked improvement in serum levels of hepatic marker enzyme AST and creatinine and urea. Although there was improvement in the levels of copper and zinc upon vitamin C treatment we observed a significant improvement in the sodium: potassium ratio after 24hrs. Vitamin C treatment also significantly reduced the level liver lipid peroxidation and improved the activities of antioxidant enzymes. Taken together our results indicate that viper venom causes oxidative damage to the liver and these effects can be counteracted by the use of an antioxidant.

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“…12 PLA2 from snake venom has been implicated in multiple pathologies including neurotoxicity, 13 nephrotoxicity, 14,15 lung toxicity, 16 hepatotoxicity 17 and cardiotoxicity. 18,19 Plant extracts constitute rich sources of pharmacologically active compounds, and some of them have been reported to antagonize the activity of various crude venoms and purified toxins. 20 This activity has been attributed to different compounds such as flavonoids, coumarins and other polyphenolic metabolites widely distributed in different plant families.…”

Section: Introductionmentioning

confidence: 99%

Antivenom activity of triterpenoid (C₃₄H₆₈O₂) from Leucas aspera Linn. against Naja naja naja venom induced toxicity

et al. 2013

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The isolated and identified triterpenoid, 1-hydroxytetratriacontane-4-one (C34H68O2), obtained from the methanolic leaf extract of Leucas aspera Linn. was explored for the first time for antisnake venom activity. The plant ( L. aspera Linn.) extract significantly antagonized the spectacled cobra ( Naja naja naja) venom induced lethal activity in a mouse model. It was compared with commercial antiserum obtained from King Institute of Preventive Medicine (Chennai, Tamil Nadu, India). N. naja naja venom induced a significant decrease in antioxidant superoxide dismutase, glutathione (GSH) peroxidase, catalase, reduced GSH and glutathione- S-transferase activities and increased lipid peroxidase (LPO) activity in different organs such as heart, liver, kidney and lungs. The histological changes following the antivenom treatment were also evaluated in all these organs. There were significant alterations in the histology. Triterpenoid from methanol extract of L. aspera Linn. at a dose level of 75 mg per mouse significantly attenuated (neutralized) the venom-induced antioxidant status and also the LPO activity in different organs.

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Histopathological changes in rat myocardium caused by Vipera ammodytes ammodytes (European viper) snake venom

Cited by 9 publications

References 3 publications

Time-course of lipid peroxidation in different organs of mice treated withEchis pyramidum snake venom

Time-course of lipid peroxidation in different organs of mice treated withEchis pyramidum snake venom

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Antivenom activity of triterpenoid (C₃₄H₆₈O₂) from Leucas aspera Linn. against Naja naja naja venom induced toxicity

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Histopathological changes in rat myocardium caused by Vipera ammodytes ammodytes (European viper) snake venom

Cited by 9 publications

References 3 publications

Time-course of lipid peroxidation in different organs of mice treated withEchis pyramidum snake venom

Time-course of lipid peroxidation in different organs of mice treated withEchis pyramidum snake venom

Untitled

Antivenom activity of triterpenoid (C34H68O2) from Leucas aspera Linn. against Naja naja naja venom induced toxicity

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Antivenom activity of triterpenoid (C₃₄H₆₈O₂) from Leucas aspera Linn. against Naja naja naja venom induced toxicity