Histopathological changes in rat liver following repeated vespine envenomation

Barr-Nea, L.; Neuman, Manuela G.; Eschar, J.; Ishay, Jacob S.

doi:10.1111/j.1600-0676.1985.tb00255.x

Cited by 11 publications

(2 citation statements)

References 13 publications

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“…Under the electron microscope, destruction of mitochondria in hepatocyte and damage to membrane of bile canaliculi were observed, which resulted in both hepatocellular damage and cholestasis in rat model. 14 In another animal model study, Neuman et al found that hepatotoxicity associated with venom sac extract was in proportion to the dose of toxin used and the liver damage was of cholangiocellular type. 15 Acute renal injury due to hymenopteran sting was found in 15.2% of cases in our study.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of Hymenoptera Sting in a Tertiary Care Hospital in Himachal Pradesh

Himral¹

2018

jemds

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BACKGROUND Hymenoptera stings are common public health hazards worldwide. Clinical spectrum of venom allergy varies from local reaction to life-threatening and unusual delayed reaction which may be fatal. MATERIALS AND METHODS This retrospective study was done to assess the clinical profile and outcome of hymenoptera sting in a tertiary care hospital in Himachal Pradesh. 33 patients admitted in medicine ward were analysed. RESULTS Incidence of hymenoptera sting was more common among females (57.6%) as compared to males (42.4%). Majority of the wasp and bee stings were observed in the months of October to December (50%). Local inflammatory reactions were present in all the patients with wasp and bee sting. Most common complication was hepatitis (39.4%) followed by hypertension 27.3%) and acute renal injury (15.2%). Mortality rate in our study was 12.1%. Local reactions were mild and resolved spontaneously. CONCLUSION Wasp and bee stings result in mild reactions to life-threatening complications, which may be delayed in onset. Therefore, early anticipation of these complications by the treating physician is needed for the management of the patient.

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Section: Discussionmentioning

confidence: 99%

Clinical Profile of Hymenoptera Sting in a Tertiary Care Hospital in Himachal Pradesh

Himral¹

2018

jemds

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“…Light microscopy and histochemistry showed foci of hepatic necrosis, a decrease in glycogen content and in succinic dehydrogenase activity, some fat infiltration and an increase in alkaline phosphatase activity. Electron microscopy showed; a decrease in the number of mitochondria per cell, a decrease in their cristae, enlargement of bile canaliculi, and destruction of the endothelium of the sinusoids bringing the cytoplasm of the necrotic hepatocytes in contact with the lumen of the sinusoid [57].…”

Section: Hepatic Effectsmentioning

confidence: 98%

Clinical manifestations of wasp stings: a case report and a review of literature

Ruwanpathirana

Priyankara²

2022

Trop Med Health

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Background Wasp stinging, a neglected tropical entity can have a myriad of local and systemic effects. We present a case of multi-organ injury following multiple wasp stings and a review of literature on the systemic manifestations of wasp stings. Case presentation A 48-year-old Sri Lankan male who suffered multiple wasp stings, developed an anaphylactic shock with respiratory failure, which was treated with adrenaline and mechanical ventilation. Within the next 2 days the patient developed acute fulminant hepatitis, stage III acute kidney injury, rhabdomyolysis, haemolysis and thrombocytopenia. The patient was treated in the intensive care unit with ionopressors and continuous renal replacement therapy (CRRT). Haemoadsorbant therapy was used in adjunct with CRRT. There was a gradual recovery of the organ functions over the 1st week. However, the patient succumbed to fungal sepsis on the 16th day despite treatment. We conducted a literature review to identify the various clinical manifestations of wasp stinging. Wasp venom contains enzymes, amines, peptides and other compounds. These proteins can cause type 1 hypersensitive reactions ranging from local skin irritation to anaphylactic shock. Furthermore, the toxins can cause direct organ injury or delayed hypersensitivity reactions. The commonly affected organs are the kidneys, liver, and muscles. The effect on the haematological system manifests as coagulopathy and/or cytopenia. The heart, nervous system, lungs, intestines and skin can be affected rarely. Treatment is mainly supportive. Conclusion In conclusion, wasp envenomation can result in multi-organ injury and attention should be paid in doing further research and establishing evidence-based treatment practices.

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Hepatotoxic effects of repeated administration of oriental hornet (vespa orientalis) venom

Neuman

Waron

Scapa

et al. 1990

Clinical Laboratory Analysis

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Venom sac extract (VSE) of the Oriental hornet (Vespa orientalis) has been shown to exert a toxic effect on hepatic cells. The present work set out to examine its effect on liver cells using serum levels of a lysosomal hydrolase as a marker of injury in rats. Serum activities of beta-N-acetyl hexosaminidase (BNAH; EC 3.2.1.30) were found to be positively correlated with the number of treatments received by the rats. The maximal elevation occurred from the third to the sixth day and comprised a 2-3-fold increase over the control mean level. This enhancement effect was reversible. The rat envenomend for 2 wk showed 3.5 times as much BNAH activity as in control rats. Biochemical analysis revealed increased specific activity of the lysosomal enzyme in rats treated repeatedly with VSE.

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Histopathological changes in rat liver following repeated vespine envenomation

Cited by 11 publications

References 13 publications

Clinical Profile of Hymenoptera Sting in a Tertiary Care Hospital in Himachal Pradesh

Clinical Profile of Hymenoptera Sting in a Tertiary Care Hospital in Himachal Pradesh

Clinical manifestations of wasp stings: a case report and a review of literature

Hepatotoxic effects of repeated administration of oriental hornet (vespa orientalis) venom

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