Methyl alcohol poisoning is an extremely hazardous poisoning commonly occurs via oral ingestion of illicit or adulterated liquors or as ethanol substitution. Toxicity results in gastrointestinal manifestations, metabolic acidosis, neurologic squeal and even death. Rapid recognition, early and aggressive management have been emphasized to prevent hazardous outcome. We hereby present a case series of 16 cases who presented to our hospital as methyl alcohol poisoning. Demographic, clinical and biochemical data were collected retrospectively from the hospital record section of the tertiary care hospital in the state of Himachal Pradesh. Out of 16 patients admitted, 12 patients had metabolic acidosis and treated with sodium bicarbonate. Four patients underwent hemodialysis for the improvement of symptoms. Five patients with severe metabolic acidosis, hypotension and altered sensorium did not be recover and succumbed.
The pathophysiology behind Coronavirus Disease-2019 (COVID-19) has remained blur even after more than two years of onset of the pandemic. Apart from pulmonary parenchymal involvement, widespread vascular thrombosis affecting both pulmonary and extra-pulmonary systems has also been seen to contribute to COVID-19 associated morbidity. This vascular manifestation often remains undiagnosed due to non specific and varied symptoms that range from asymptomatic detection to life threatening presentations. A series of six COVID-19 positive (three male and three female) cases who presented with thrombosis of pulmonary, coronary and cerebral vessels despite being on thromboprophylaxis are reported herein. The age of patients ranged from 32 to 80 years. Out of six patients, three had comorbidities. The most common complication was Pulmonary Thromboembolism (PTE, n=4) followed by Myocardial Infarction (MI, n=1) and cerebellar infarct (n=1). Out of three patients with PTE, one patient had concurrent Deep Vein Thrombosis (DVT). All patients were managed as per guidelines issued by the Ministry of Health and Family Welfare for severe COVID-19 disease. Out of six patients, three patients died and three were discharged. The series highlights the need for high index of suspicion on the part of the treating physician that could aid in early detection and successful management of this potentially fatal condition.
A 43-year-old male using valproic acid (VA) for 2 years for seizure disorder presented with right-sided moderate pleural effusion. Pleural fluid analysis revealed exudative effusion with 42% eosinophils. There was no evidence of haemothorax, pneumothorax, malignancy, and parasitic infections. Suspecting a drug-related event, VA was discontinued. The patient showed clinical improvement with resolution of pleural effusion on chest radiograph three weeks later. VA is a popular drug used for variety of disorders like seizures, migraines, and schizophrenia. There is a paucity of literature on VA-induced pleural effusion. Though a rare phenomenon, clinicians should be aware of such a possibility to avoid erroneous diagnosis.
Thyrotoxicosis has various clinical manifestations, ranging from its usual features to some rare presentations. Thyrotoxicosis presenting as acute quadriplegia is a very rare phenomenon and is attributed to hypokalemia. Thyrotoxic hypokalemic periodic paralysis is a known but rare manifestation, and a first presentation is relatively unknown in the past. Here, we present a case of middle-aged Asian male in whom thyrotoxicosis presented for the first time as hypokalemic paralysis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.