Histopathological Assessment of Dyspepsia in
the Absence of Endoscopic Mucosal Lesions

Dawod, Hosam M; Emara, Mahmoud

doi:10.5005/jp-journals-10018-1178

Cited by 10 publications

(17 citation statements)

References 22 publications

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“…Epigastric pain, morning vomiting and upper abdominal distention were more prevalent in H pylori positive cases than negative ones (Table 2). Our result was in agreement with other studies done in Egypt by Dawod and Emara, 2016 and in Sudan by Abdallah et al, 2014. In the present study we found that farmers acquire H pylori infection (82.1%) significantly more than nonfarmers (64.9%) ( Table 3). Also, farming occupation was associated with H pylori infection among 91.7% of dyspeptic patients in Ghana (Archampong et al, 2015).…”

Section: Discussionsupporting

confidence: 94%

Prevalence of Helicobacter Pylori Infection Among Farmers and Non-Farmers With Dyspepsia

Salem

Sakr

Younis

et al. 2019

Egypt. J. Occup. Med.

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Introduction: Helicobacter pylori (H pylori) is a gram negative spirally shaped bacterium. It is known to be the most common cause of dyspepsia especially in developing countries as Egypt. Aim of work: To identify the prevalence of H pylori among patients with dyspepsia especially farmers and the infection risk factors. Materials and methods: This is a hospital based cross-sectional study conducted on 152 patients (78 farmers and 74 non-farmers) with dyspepsia among those admitted to Gastrointestinal (GI) Endoscopy Unit at Menoufia University hospital, Menoufia, Egypt. They were recruited to this study from 1 st September 2017 to the end of May 2018. Designed questionnaire, clinical examination, esophago-gastro-duodenoscopy (EGD) and histopathological evaluation were conducted to the studied patients. Results: The overall prevalence rate of H pylori among dyspeptic patients in the current study was (73.7%) and significantly higher among low levels of education (28.6%), female gender (69.6%), farmers occupation (57.1%), low socioeconomic status (28.6%), who consume tap water for drinking (76.8%) and unwashed vegetables (73.2%). Epigastric pain was more common in patients with H pylori (P <0.001). Also, acid reflux, morning vomiting and upper abdominal distention were significantly more prevalent among H pylori positive cases. About (82.1%) of farmers were significantly positively infected than non-farmers (64.9%). Illiterate female farmers who didn't wash vegetables and with history of peptic ulcers were more susceptible of infection. Conclusion: Farmers occupation was at risk of H pylori infection than non-farmers. Illiteracy, bad sanitation and low hygienic standard were the risk factors of infection. Health education and environmental sanitation are recommended to lower the prevalence of H pylori especially among farmers.

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Section: Discussionsupporting

confidence: 94%

Prevalence of Helicobacter Pylori Infection Among Farmers and Non-Farmers With Dyspepsia

Salem

Sakr

Younis

et al. 2019

Egypt. J. Occup. Med.

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“…In the present study 81.7% of the patients had positive histopathological findings in esophageal biopsies associated with the dyspeptic symptoms. This finding is matching with the results reported by Dawod & Emara (4) and Nwokediuko & Okafor (27) ). This could be explained by the presence of other causes of inflammation than H. pylori or previous ingestion of antibiotics, which are known to suppress the H. pylori infection with a slow disappearance of chronic inflammatory cells (28) .…”

Section: Discussionsupporting

confidence: 93%

“…Despite Dyspepsia : is a common symptom, only 25% of patients with dyspepsia have an organic cause and up to 75% have functional dyspepsia (1) . The underline causes of dyspepsia included major causes as medications, functional dyspepsia, chronic peptic ulcer disease, and malignancy (4) . Other minor causes for dyspepsia include pancreatic disease, hepatobiliary tract disease, motility disorders, infiltrative diseases of the stomach, celiac disease, metabolic disturbances, diabetic neuropathy, and hernia (4) .…”

Section: Introductionmentioning

confidence: 99%

“…The underline causes of dyspepsia included major causes as medications, functional dyspepsia, chronic peptic ulcer disease, and malignancy (4) . Other minor causes for dyspepsia include pancreatic disease, hepatobiliary tract disease, motility disorders, infiltrative diseases of the stomach, celiac disease, metabolic disturbances, diabetic neuropathy, and hernia (4) . Researches revealed that 73% of gastroenterologists and 59% of primary care providers are aware with dyspepsia best practices.…”

Section: Introductionmentioning

confidence: 99%

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Pattern of Endoscopic Esophageal Findings in Relation to Helicobacter Pylori Infection and Histopathology: A Single Center Experience

Moussa

Gawad

Nosseir

2019

Suez Canal University Medical Journal

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Background: Dyspepsia is a common complain among people suffering from gastrointestinal diseases. Few researches investigated the underlying causes in detail. H. Pylori is considered a major finding in patients with dyspepsia and diagnosed with gastrointestinal diseases. Aim: The aim of this study is to determine the pattern of Endoscopic Esophageal lesion in Relation to H. Pylori infection and histopathological features of esophageal and gastric mucosal biopsies in dyspeptic patients eligible for upper GIT Endoscopy. Patients and Methods: all the patients presented with dyspeptic symptoms and were eligible for upper GIT endoscopy during the period from January 2016 to January 2019were included (n=60). Using endoscopy, gastric biopsies were taken for H. Pylori examination and esophageal lesions biopsies were taken for histopathological examination (n=120 specimens). Results: the prevalence of H. pylori among patients with dyspepsia was 81.7%. The most common endoscopic esophageal pattern with H. pylori was erythema and abnormal vascular pattern (67.3%). Reflux esophagitis was the most common Histopathological finding in H. Pylori positive patients (57.1%). Chronic non-specific esophagitis was higher in H. Pylori negative (9.1%) compared with H. Pylori positive (8.2%). Adenocarcinoma was found in 16.3% of H. Pylori positive patients, however, squamous cell carcinoma was more in H. Pylori negative (27.3%) than H. Pylori positive (6.1%). Conclusion: The majority of patient with dyspepsia has H. Pylori infection. Risk factors for malignant esophageal lesions are old age, male gender, smoking and H. pylori infection

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“…[18] For example, Talebi-Taher et al, Ford et al, and Dawod and Emara in their studies found higher prevalence of dyspepsia in females than males. [16,19,20] In a Norwegian study of over 14,000 people, Johnsen et al found a significantly higher rate of FD in men compared with women (22.6 vs. 18.1%; P < 0.05). [21] A review done to study the epidemiology of uninvestigated FD in Asians revealed that there is no gender predilection.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Upper Gastrointestinal Endoscopy and Prevalence of Helicobacter Pylori Infection in Dyspeptic Type 2 Diabetes Mellitus Patients

Vaishnav

Shaikh

Bamanikar

et al. 2018

Journal of Digestive Endoscopy

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Introduction: Multisystem involvement is a norm in Type 2 diabetes mellitus (T2DM). Dyspepsia is a common gastrointestinal (GI) tract symptom in people with diabetes. We aimed to study the esophageal, gastric, and duodenal mucosal changes; presence of Helicobacter pylori (HP) infection; and its significance in dyspeptic diabetes patients. Materials and Methods: A prospective observational study done on 287 patients (147 patient with diabetes and 140 nondiabetic controls) with dyspepsia of more than 6 months duration. All patients underwent upper GI endoscopy and evaluation for HP infection. Gross and histopathological examination (HPE) features of biopsies from the esophagus, stomach (fundus, body, and antrum), and duodenum were analyzed and rapid urease test as well as HPE was done for HP detection. Statistical analysis was done and results were expressed as mean ± standard deviation. P < 0.05 was considered to be statistically significant. Results: Average age for dyspeptic T2DM patients was 56.0 ± 8.44 years. Total 67.35% diabetes patients were addicted to tobacco. Epigastric pain and heartburn were the most common symptoms. Antral gastritis was the most common gross (75.08%) and HPE (70.38%) finding in patients with diabetes. In all, 44.21% patients with diabetes tested positive for HP infection, and there was a statistically significant association of HP with T2DM when compared with nondiabetics (P < 0.00001). However, HP infection did not correlate significantly with either glycosylated hemoglobin (HbA1c) or duration of T2DM. Conclusion: Antral gastritis was a common finding in dyspeptic diabetic patients. HP infection although associated with T2DM dyspeptic patients, was not associated with either uncontrolled sugar levels or duration of diabetes.

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Histopathological Assessment of Dyspepsia in the Absence of Endoscopic Mucosal Lesions

Cited by 10 publications

References 22 publications

Prevalence of Helicobacter Pylori Infection Among Farmers and Non-Farmers With Dyspepsia

Prevalence of Helicobacter Pylori Infection Among Farmers and Non-Farmers With Dyspepsia

Pattern of Endoscopic Esophageal Findings in Relation to Helicobacter Pylori Infection and Histopathology: A Single Center Experience

Diagnostic Upper Gastrointestinal Endoscopy and Prevalence of Helicobacter Pylori Infection in Dyspeptic Type 2 Diabetes Mellitus Patients

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