Histopathological Appearance of Artificially Produced Caries-Like Lesions of Enamel Treated with APF during Lesion Formation in vitro

Abstract

A single application of APF to sound enamel before exposure to an artifical caries system in vitro had no effect on subsequent lesion formation. However, when initial lesions were treated with APF (1.23%F) and re-exposed to the artificial caries system histological changes were produced indicative of remineralization within the lesion. This suggests that topically applied fluoride may exert its maximal effect on initial lesions rather than on sound enamel.

Relationship between the Extent of the Initial Lesion and the Inhibitory Effect of APF on the Progression of Caries-Like Lesions in vitro

“…There is now considerable evidence to support the hypothesis that the presence of fluoride during lesion formation is essential to its caries inhibitory action [Lemke et al, 1970;Horowitz and Kau, 1974;Houwink et al, 1974;Joyston-Bechal and Kidd, 1980], The results of the present study confirm previous work [Joyston-Bechal and Kidd, 1980] showing that when initial lesions are treated with APF (1.23% F) and re-exposed to an artificial caries system, histological changes are produced indicative of reminer alisation within the lesion. In the present study specimens were also exposed to artifi cial saliva for 24 h following fluoride appli cations.…”

“…On the other hand, when initial lesions were treated with APF (1.23% F) and re-exposed to the artificial caries sys tem histological changes were produced in dicative of remineralisation within the lesion [Joyston-Bechal and Kidd, 1980], However, in spite of such evidence of remineralisa tion, the fluoride-treated lesions progressed to a similar depth as the untreated controls. Consequently, the aim of the present study was to determine whether the extent of a le sion at the time of fluoride treatment was a relevant factor to its subsequent progress when re-exposed to the caries-like attack.…”

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

“…This result is encouraging as others have shown that preventive measures are most effective when the WSL formation is in its earliest stage because remineralization can take place if the lesions are less than 65 mm in depth. 30 Others have also demonstrated that a WSL after 3 months in vivo typically extends to around 100 mm deep. 1 Since the BAG-bond adhesives in this study reduced demineralization at these superficial depths, these adhesives hold potential for preventing WSL formation within the boundaries of what occurs in vivo.…”