Histopathological and Ultrastructural Alterations in The Renal Cortex of Albino Mice Foetuses Induced by Beta-Lactam Antibiotic 'Amoxicillin'

Abstract

Background: The aim of this investigation was to evaluate the effect of a low and high doses (205 & 820mg/kg body weight, respectively) of the beta-lactam antibiotic amoxicillin on the kidney of maternally treated mice foetuses. Material and Methods: Pregnant mice were allocated into three groups; the first group served as control (injected with the drug solvent) and those of the other two groups were injected intraperitoneally with two doses (205 & 820 mg/kg body weight) of amoxicillin for 8 days from day 7 till day14 during gestation. Results: The histological examination of the renal cortex of maternally treated foetuses showed erosion of the parietal cells of Bowman's capsule, hypoplasia of the mesangial cells of the glomerulus, and erosion of the epithelial cells lining the proximal and distal convoluted tubules. At the electron microscopical level, the alternations of the renal cortex of foetuses maternally treated with amoxicillin were represented by, fusion of the foot processes of the podocytes and partial destruction of the apical brush borders microvilli of the proximal convoluted tubule cells. Also, degeneration of some mitochondria, and fragmentation of the rough endoplasmic reticulum elements of the lining cells of some proximal and distal convoluted tubules were observed. Conclusions:The uses of amoxicillin should be under restricted precautions specially for the pregnant women to avoid the hazardous impact.

[Retracted] Deleterious Effects of Amoxicillin on Immune System and Haematobiochemical Parameters of a Rabbit

“…In our latest microscopic examination, we observed increased Bowman's space, congestion, necrosis of renal tubular epithelial cell, nuclear hypertrophy, necrosis of renal tubules, degeneration of renal tubule, degenerative changes in kidney glomerulus, widening of the urinary space, hemorrhage b/w tubule, and cell infiltration with pyknotic nuclei in the kidney of amoxicillin-treated rabbits, while previous studies reported that the renal cortex of maternally treated foetus showed erosion of the parietal cells of Bowman's capsule, hypoplasia of the mesangial cells of the glomerulus, and erosion of the epithelial cells lining the proximal and distal convoluted tubules. In the electron microscope level, the renal cortex of foetus maternally treated with amoxicillin showed fusion of the foot processes of the podocytes, partial destruction of the apical brush borders microvilli of the proximal convoluted tubule cells, degeneration of some mitochondria, and fragmentation of the rough endoplasmic reticulum elements [ 20 ] ( Table 7 ). In recent microscopy, we observed necrosis of cardiac cells, cytoplasmic vacuolization, congestion, neutrophilic myocarditis, myofibrillolysis, and pyknotic nuclei in amoxicillin-treated rabbits, while in a previous study, no authentic and related research data are available on heart pathology in connection to our study ( Table 7 ).…”