Histopathological and immunological changes induced by magnetite nanoparticles in the spleen, liver and genital tract of mice following intravaginal instillation

Awaad, Aziz

doi:10.1016/j.jobaz.2015.03.003

Cited by 36 publications

(13 citation statements)

References 39 publications

(51 reference statements)

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“…This increment is to compensate decreased platelets count previously mentioned in our results and confirmed by Aula et al . Moreover, Awaad added that the number and size of the splenic megakaryocytes were highly increased after magnetic NPs.…”

Section: Discussionsupporting

confidence: 90%

“…Similar observations were reported by Mansouri et al on hepatocytes and Wang et al on splenocytes after ZnO NPs. Furthermore, other NPs like magnetite NPs were documented by Awaad to induce degeneration of splenocytes with multiple vacuoles and shrunken or condensed nuclei.…”

Section: Discussionmentioning

confidence: 99%

“…after ZnO NPs. Furthermore, other NPs like magnetite NPs were documented by Awaad (57) to induce degeneration of splenocytes with multiple vacuoles and shrunken or condensed nuclei.…”

Section: Discussionmentioning

confidence: 99%

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Effect of orally administered zinc oxide nanoparticles on albino rat thymus and spleen

Abass

Selim

et al. 2017

IUBMB Life

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This study aimed to evaluate the toxicological effects of oral intake of Zinc oxide nanoparticles (ZnO NPs) on the structure of thymus and spleen. Twenty-four young male Wistar albino rats were assigned into two groups: group I (control) and group II (ZnO NPs treated group).The thymus and spleen were analyzed biochemically, histopathologically and immunohistochemically. After ZnO NPs intake, hematologically, the total leucocytic count was significantly increased while the RBCs and platelets counts and Hb % were significantly decreased. Biochemically, a significant decrease in serum total antioxidant capacity and anti-inflammatory cytokines including interleukin 4 and 10 (IL-4 and IL-10) levels was noted. While a significant increase in splenic and thymic malondialdehyde (MDA) and DNA shearing, as well as the studied proinflammatory cytokines; IL-1β, tumor necrotic factor (TNF-α) and interferon (INF-γ) levels was detected. Notably, we noted upregulation of the immunomodulatory [CD3, CD11b, heme oxygenase (HO-1)] and the inflammatory [toll-like receptor 4 and 6 (TLR4 and TLR6)] genes. Histopathologically, degenerative changes were detected in thymus and spleen of ZnO NPs treated group. While the immunohistochemical analysis of the ZnO NPs treated group revealed a decrease in the number of cells expressed positive reactions of anti-PCNA and an increase in the number of cells expressed positive reaction of anti-p53 in the thymus and spleen. In conclusion, ZnO NPs induced obvious immunotoxicity in the thymus and spleen, where oxidative/inflammatory pathway may be the potential mechanism underlying this immunotoxicity. © 2017 IUBMB Life, 69(7):528-539, 2017.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Effect of orally administered zinc oxide nanoparticles on albino rat thymus and spleen

Abass

Selim

et al. 2017

IUBMB Life

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“…These results agree with Karabasz et al ( 83 ), who reported the safety and efficiency of nutrient delivery via organic nanocapsules. However, it is important to obtain detailed information and verify the safety of nanomaterials before use in human clinical trials ( 84 ).…”

Section: Biological Experimentsmentioning

confidence: 99%

Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats

et al. 2021

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Iron deficiency anemia (IDA) is a major health concern in developing countries, and these see an increased incidence in pregnant women and children in particular. The contribution of dairy products as natural products in drug delivery approaches is inspiring. This study aimed to analyze the application of iron (Fe) and folic acid (FA) bovine serum albumin-nanoparticles (BSA-NPs) as anti-anemic pharmacological agents that fortify stirred functional yogurt (SFY), comparing these with a plain control and SFY fortified with Fe and FA in free forms. The physicochemical, cytotoxicity, microbiological, viscosity, oxidative interactions, microstructural, sensorial analyses, and bioavailability properties of IDA-induced Albino rats were examined. The Transmission Electron Microscope (TEM), Zetasizer, and Scan Electron Microscope (SEM) were applied. Nanocapsule-fortified SFY showed an enhanced apparent viscosity, water-holding capacity, microstructure, least lipid oxidation, and overall sensorial acceptability. Feed that included Fe + FA nanocapsule-fortified SFY (G6) succeeded in restoring hemoglobin (16.53 gdL−1), iron (109.25 μgdL−1), ferritin (33.25 μgdL−1), and total protein (8.6 gdL−1) at the end of the 4-week feeding period, with significant competition revealed in calcium and zinc absorbance. Nanocapsule-fortified SFY showed no adverse effects or architectural alterations in the liver, kidney, or spleen, as indicated by biochemical and histological examinations. Bovine serum albumin-nanoparticles (BSA-NPs) of iron (Fe) and folic acid (FA) can be recommended as anti-anemia supplements in different functional food applications.

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“…Xu et al reported that Ti02 nanoparticles in mice caused a serious increase in the number of white blood cells [83]. Besides, iron oxide nanoparticles cause an increase in the number of white blood cells, and the liver and spleen are the most affected organs immunologically [84].…”

Section: Immune Systemmentioning

confidence: 99%

Nanotoxicity: a challenge for future medicine

Akçan¹,

Aydoğan²,

Yıldırım³

et al. 2020

Turk J Med Sci

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Background/aim: Due to nanomaterials' potential benefits for diagnosis and treatment, they are widely used in medical applications and personal care products. Interaction of nanomaterials, which are very small in size, with tissue, cell and microenvironment, can reveal harmful effects that cannot be created with chemically identical and larger counterparts in biological organisms. In this review, a challenge for future medicine, nanotoxicity of nanomaterials is discussed. Materials and methods: A detailed review of related literature was performed and evaluated as per medical applications of nanomaterials their toxicity. Results and conclusion: Most authors state "the only valid technology will be nanotechnology in the next era"; however, there is no consensus on the impact of this technology on humankind, environment and ecological balance. Studies dealing with the toxic effect of nanomaterials on human health have also varied with developing technology. Nanotoxicology studies such as in vivo-like on 3D human organs, cells, advanced genetic studies, and-omic approaches begin to replace conventional methods. Nanotoxicity and adverse effects of nanomaterials in exposed producers, industry workers, and patients make nanomaterials a double-edged sword for future medicine. In order to control and tackle related risks, regulation and legislations should be implemented, and researchers have to conduct joint multidisciplinary studies in various fields of medical sciences, nanotechnology, nanomedicine, and biomedical engineering.

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Histopathological and immunological changes induced by magnetite nanoparticles in the spleen, liver and genital tract of mice following intravaginal instillation

Cited by 36 publications

References 39 publications

Effect of orally administered zinc oxide nanoparticles on albino rat thymus and spleen

Effect of orally administered zinc oxide nanoparticles on albino rat thymus and spleen

Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats

Nanotoxicity: a challenge for future medicine

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