Histopathological and immunohistochemical study of rat brain tissue after exposure to mobile phone radiation

Razavi, Morteza; Raji, Ahmad Reza; Maleki, Mohsen; Dehghani, Hesam; Haghpeima, Alireza

doi:10.1007/s00580-015-2113-0

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…In this context, the last decades, researchers have revealed that electromagnetic fields can produce adverse effects on different regions of human and experimental animal bodies [2,3]. These effects have been undoubtedly proven in homeostatic systems, the nervous [4][5][6], endocrine [7,8] and immune [9] systems, and, consequently, exposure to EMFs can lead to loss of health and increase the risk of suffering pathologies [10]. Moreover, EMFs can affect the sleep regulation [11], being more significant the effect on health of the exposure of EMFs at nighttime than at daytime [12], since nocturnal sleep has a homeostatic role, being necessary for efficient consolidation of cognitive, metabolic and immune functions [13].…”

Section: Introductionmentioning

confidence: 99%

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields

et al. 2022

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Background The electromagnetic fields (EMFs) emitted by the technologies affect the homeostatic systems (nervous, endocrine, and immune systems) and consequently the health. In a previous work, we observed that men and women, after 2 months of using a bed with a registered HOGO system, that prevents and drain EMFs, improved their immunity, redox and inflammatory states and rejuvenated their rate of aging or biological age. Since, EMFs can act as a chronic stressor stimulus, and affect the sleep quality. The objective of this work was to study in men and women (23–73 years old) the effect of sleeping for 2 months on that bed in the blood concentrations of several hormones related to stress response and sleep quality as well as to corroborate the rejuvenation of their biological age. Methods In 18 men and women, plasma concentration of cortisol, dehydroepiandrosterone (DHEA), catecholamines (epinephrine, norepinephrine and dopamine), serotonin, oxytocin and melatonin were analyzed before and after 2 months of using the HOGO beds. A group of 10 people was used as placebo control. In another cohort of 25 men (20 experimental and 5 placebo), the effects of rest on the HOGO system on the concentration of cortisol and testosterone in plasma were studied. In all these volunteers, the biological age was analyzed using the Immunity Clock model. Results There is a significant increase in plasma concentration of DHEA, norepinephrine, serotonin, oxytocin, and melatonin as well as in testosterone, after resting for 2 months in that bed with the EMFs avoiding system. In addition, decreases in Cortisol/DHEA and Testosterone/cortisol ratio and plasma dopamine concentration were observed. No differences were found in placebo groups. In all participants that slept on HOGO beds, the biological age was reduced. Conclusions Sleeping in a bed that isolates from EMFs and drain them can be a possible strategy to improve the secretion of hormones related to a better response to stress and sleep quality, which means a better endocrine system, and consequently better homeostasis and maintenance of health. This fact was confirmed with the slowdown in the rate of aging checked with a rejuvenation of the biological age.

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Section: Introductionmentioning

confidence: 99%

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields

et al. 2022

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“…The studies of Kesari et al [30] (Testes of rat) and Kafaee Razavi et al [5] (rat brain tissue) showed a signi cant rise in apoptosis across all experimental groups exposed to electromagnetic waves at a high frequency. Although the duration and the intensity of the electromagnetic eld in the experimental groups were different, their results have been similar to ours.…”

Section: Discussionmentioning

confidence: 91%

“…Berg, in 1999 found that the intensity, duration of exposure, and frequency of waves were three important factors for the effects of electromagnetic waves on the cell body function [4]. Elsewhere, Kafaee Razavi et al observed that exposure to electromagnetic elds with a 940 MHz frequency increased blood-brain barrier permeability and apoptosis across all exposed groups [5]. On the other hand, more research has shown that the radiation severity and duration of RF-EMR will in uence the parameters of male reproduction valence; these parameters include the concentration [6], mobility [7,8], morphology [9][10][11][12][13], the viability of sperm cells [6, 14,15] and sperm apoptosis [16,17].…”

Section: Introductionmentioning

confidence: 99%

Investing the effect of 2100 MHz frequency electromagnetic field on the male rat reproductive system

Ghasemiannejadjahromi

Raji

Maleki

et al. 2022

Preprint

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Background: This research aimed to appraise the 2100 MHz frequency of the new generation of mobile phones on the male rat reproductive system. The genital organ is one of the important systems for sustaining reproduction and generation. The consequences of mobile phone radiation exposure have been a growing general health worry in recent years. Study design: 35 Wister albino male rats were randomly divided into five groups for this study. The groups were exposed to a 2100 MHz frequency electromagnetic field for 0, 15, 60,120, 180 min/day, 70 consecutive days. At the end of the experiment, serum testosterone levels were measured, and each group was evaluated for epididymal sperm parameters, including mobility, morphology, and viability. Then, immunohistochemistry staining was performed by Cleaved-Caspase 3 antibody to show apoptosis in the testicular tissue. Results: Our results revealed that serum testosterone levels were significantly reduced in experimental groups (60 and 120 min). In addition, sperm motility was significantly reduced in experimental groups (60, 120, and 180 min), and a significant decline of sperm viability and apoptosis (P=0.001) was observed in all groups. Conclusion: This study found a significant increase in the number of dead sperm and apoptosis and a significant reduction in motility, which could impair the spermatogenesis process, reduce sexual characteristics, and eventually lower the rate of fertility.

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“…Othman (2012) has suggested that, the lysosomal damage and Nissl bodies destruction as a result of acidophilia are the main causes of edema and chromatolysis in the EMR-exposed rats (Othman, 2012). Recently, the changes in brain tissue that could be caused by thirty minutes exposure to EMF at 940-MHz frequency (mobile phone radiation) have been studied (Razavi et al, 2015). The study revealed increase in apoptotic cells, increase in BBB permeability (albumin leakage from BBB) and increase in BBB space causing changes in the structure of BBB (edema).…”

Section: Resultsmentioning

confidence: 99%

Transdermal patches loaded with L-cysteine HCL as a strategy for protection from mobile phone emitting electromagnetic radiation hazards

Omar

Nasr

Rafla

2019

Saudi Pharmaceutical Journal

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Mobile phone usage has been increased in the last few years emitting electromagnetic radiation (EMR), which disturbs normal cellular processes via oxidative stress. L-cysteine, a glutathione precursor, prevents oxidative damage. Transdermal patches (TDPs) loaded with L-cysteine hydrochloride (L-CyS-HCL) were fabricated by dispersion of L-CyS-HCL 5% w/w and different concentrations of sorbitol as a plasticizer in room-temperature vulcanizable synthetic silicone matrices (RTV-Si). The effect of sorbitol on patch physicochemical parameters was assessed; in-vitro L-CyS-HCL release profiles and ex-vivo permeation were studied. Pharmacokinetic parameters of endogenous synthetized in-vivo glutathione, after receiving IV bolus dose of L-CyS-HCl and L-CyS-HCl-RTV-Si-TDPs were studied in rat model. The influence of L-CyS-HCL-RTV-Si-TDPs against damaging effects of mobile phone EMR on rats' blood and brain tissues was studied. The results revealed that patch plasticity, intensity reflections, surface porosity, L-CyS-HCL release rate and skin permeation increased with increasing sorbitol concentration. Pharmacokinetic profile for IV dose and L-CyS-HCl-RTV-Si-TDPs revealed that the L-CyS-HCl-RTV-Si-TDPs provided a sustained glutathione plasma concentration–time profile over entire patch application. High significant differences in biological parameters (blood and brain samples) were observed for radiated rats using the patch in study compared with positive control rats. Promising long-term strategy for protection against mobile phone hazards was obtained.

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Histopathological and immunohistochemical study of rat brain tissue after exposure to mobile phone radiation

Cited by 6 publications

References 12 publications

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields

Investing the effect of 2100 MHz frequency electromagnetic field on the male rat reproductive system

Transdermal patches loaded with L-cysteine HCL as a strategy for protection from mobile phone emitting electromagnetic radiation hazards

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