Histopathological and Biochemical Effects of Thyme Essential Oil on H2O2 Stress in Heart Tissues

Guesmi, Fatma; Khantouche, Linda; Mehrez, Amel; Bellamine, Houda; Landoulsi, Ahmed

doi:10.1016/j.hlc.2018.12.008

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…In the case of long-term LPS pretreatment all three EOs acted at the same level, suggesting both scavenging- and enzyme-triggering functions. TEO/end of flowering pretreatment followed by long-term LPS treatment raises the possibility that it enhances the effects not only of enzymatic but also of nonenzymatic antioxidants, such as glutathione [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Thyme (Thymus vulgaris L.) Essential Oils Prepared at Different Plant Phenophases on Pseudomonas aeruginosa LPS-Activated THP-1 Macrophages

et al. 2022

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Thyme (Thymus vulgaris L.) essential oil (TEO) is widely used as an alternative therapy especially for infections of the upper respiratory tract. TEO possesses antiviral, antibacterial, and antifungal properties. The emerging antibiotic resistance of bacterial strains, including Pseudomonas aeruginosa, has prompted the urge to find alternative treatments. In the present study, we examined the anti-inflammatory and antioxidant effects of thymol, the main compound of TEO, and two TEOs prepared at the beginning and at the end of the flowering period that may make these oils promising candidates as complementary or alternative therapies against P. aeruginosa infections. The activity measurements of the antioxidant enzymes peroxidase (PX), catalase (CAT), and superoxide dismutase (SOD) as well as the determination of total antioxidant capacity of P. aeruginosa-activated THP-1 cells revealed that thymol and both TEOs increased CAT and SOD activity as well as the antioxidant capacity of the THP-1 cells. The measurements of the proinflammatory cytokine mRNA expression and secreted protein level of LPS-activated THP-1 cells showed that from the two TEOs, only TEO prepared at the beginning of the flowering period acted as a potent inhibitor of the synthesis of IL-6, IL-8, IL-β, and TNF-α. Our results suggest that not only thymol, but also the synergism or the antagonistic effects of the additional compounds of the essential oils are responsible for the anti-inflammatory activity of TEOs.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Thyme (Thymus vulgaris L.) Essential Oils Prepared at Different Plant Phenophases on Pseudomonas aeruginosa LPS-Activated THP-1 Macrophages

et al. 2022

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“…Thymus vulgaris (thyme) synthesizes terpene alcohols and phenols which are known to have powerful antibacterial and antifungal properties (Cox-Georgian et al 2019). Among all the terpenes present in thyme essential oil, thymol and carvacrol are the major phytochemicals having immense medicinal properties (Guesmi et al 2018). T. vulgaris is commonly used in the treatment of many diseases especially in inflammation-related ailments, such as rheumatism, muscles swelling, insect bites, and pains.…”

Section: Different Species Of the Genus Mentha Contain Different Terpmentioning

confidence: 99%

Potential Uses of Bioactive Compounds of Medicinal Plants and Their Mode of Action in Several Human Diseases

Choudhary

Zehra

Mukarram

et al. 2021

Medicinal and Aromatic Plants

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“…An oily fraction of T. algeriensis was demonstrated as a potential agent for the therapy of oxidative stress‐induced heart disease. It could deplete H 2 O 2 ‐induced protein oxidation and lipid peroxidation, enhance antioxidant defense enzymes and protect against H 2 O 2 ‐induced histopathological alterations …”

Section: Biological Activitiesmentioning

confidence: 99%

“…It could deplete H 2 O 2 -induced protein oxidation and lipid peroxidation, enhance antioxidant defense enzymes and protect against H 2 O 2 -induced histopathological alterations. [110] Thymol was the main phenolic compound of T. quinquecostatus CLEAK methanol extract and it could prevent oxidative stress-induced damage to liver cells through suppression of ROS and malondialdehyde (MDA) levels and increase of glutathione (GSH) level. [43,111] And the strong antioxidant activity indicated that the plant had considerable potential as an antioxidant food additive.…”

Section: In Vitromentioning

confidence: 99%

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Wang

et al. 2019

Chemistry & Biodiversity

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The genus Thymus (Lamiaceae) comprises about 214 species throughout the world, mainly found in North Africa, Europe, and temperate Asia zone. They are traditionally used as food additives and folk medicines. This review comprehensively summarizes information about traditional uses, chemical constituents, and biological activities of this genus and provides recommendations for future investigations. All information was gathered from scientific databases including Google Scholar, Sci‐Finder, Web of Science, ScienceDirect, and CNKI. Volatile oils are the most concerned constituents of this genus. Flavonoids, phenylpropanoids, tannins, organic acids, terpenoids, and phytosterols were also summarized. This genus plants possessed a variety of activities including antimicrobial, antioxidant, anti‐inflammatory, cytotoxic, analgesic, and antidiabetic. In brief, this review will be helpful to provide valuable data for explorations and create more interests towards Thymus genus in the future.

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Histopathological and Biochemical Effects of Thyme Essential Oil on H2O2 Stress in Heart Tissues

Cited by 7 publications

References 31 publications

Antioxidant and Anti-Inflammatory Effects of Thyme (Thymus vulgaris L.) Essential Oils Prepared at Different Plant Phenophases on Pseudomonas aeruginosa LPS-Activated THP-1 Macrophages

Antioxidant and Anti-Inflammatory Effects of Thyme (Thymus vulgaris L.) Essential Oils Prepared at Different Plant Phenophases on Pseudomonas aeruginosa LPS-Activated THP-1 Macrophages

Potential Uses of Bioactive Compounds of Medicinal Plants and Their Mode of Action in Several Human Diseases

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

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